Spontaneous Coronary Artery Dissection in a Patient With Cushing's Disease

Vieira, Joana T; Besteiro, Bruno; Faceira, Ana; Marques, Pedro; Almeida, Jorge

doi:10.7759/cureus.36370

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Other features of endothelial dysfunction are the decreased aorta elasticity and decreased endotheliumdependent vasodilatation mediated by the blood fl ow. The untreated patients with GHD have the systolic function disorder, and after 6 months of hormonal substitution therapy a considerable improvement of cardiac index, increased cardiac output, systolic discharge, decreased diastolic arterial pressure are observed [24]. Hyperprolactinemia is able to cause considerable metabolic changes which, in turn, increase cardiovascular risks.…”

Section:  Hypophisial Disordersmentioning

confidence: 99%

Cardiac Complications of Endocrine Diseases: A Literature Review

Воронин,

Керимова,

Хворостова

et al. 2024

Кардиология В Беларуси

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Эндокринные нарушения почти во всех случаях приводят к патологическому изменению метаболизма, включая дислипидемии и ухудшение обмена углеводов. Так, недостаточный контроль гликемии при сахарном диабете способствует повышению уровня триглицеридов и развитию атерогенной дислипидемии. В свою очередь это способствует изменениям в сердечно-сосудистой системе на структурном и функциональном уровне. Частыми явлениями могут быть: повышение жесткости артериальной стенки, гипертензии, кардиомиопатии, атеросклероз сосудов, ишемическая болезнь сердца и сердечная недостаточность. Гиперхолестеринемия способствует возникновению микрососудистых повреждений, повышению вязкости крови, воспалению, тромбозу, окклюзии сосудов, атерогенезу. Кроме того, эндокринные заболевания активируют и другие патогенные механизмы, включая усиление чувствительности миокарда к адренергической системе и прямое токсическое действие на сердечную мышцу. При отсутствии своевременного и адекватного лечения возрастают риски смерти от поздних сердечно-сосудистых осложнений. Правильно подобранная терапия позволяет не только нормализовать обмен веществ, но и значительно нивелировать патологические процессы в кардиоваскулярной области или отодвинуть время их возникновения на поздний этап жизни. Endocrine disorders in almost all cases lead to pathological changes in metabolism, including dyslipidemia and deterioration of carbohydrate metabolism. Thus, insufficient glycemic control in diabetes mellitus contributes to an increase in triglyceride levels and the development of atherogenic dyslipidemia. In turn, this promotes changes in the cardiovascular system at the structural and functional level. Frequent phenomena may include: increased stiffness of the arterial wall, hypertension, cardiomyopathy, vascular atherosclerosis, coronary heart disease and heart failure. Hypercholesterolemia contributes to the occurrence of microvascular damage, increased blood viscosity, inflammation, thrombosis, vascular occlusion, and atherogenesis. In addition, endocrine diseases activate other pathogenic mechanisms, including increased sensitivity of the myocardium to the adrenergic system, and a direct toxic effect on the heart muscle. In the absence of timely and adequate treatment, the risks of death from late cardiovascular complications increase. Properly selected therapy allows not only to normalize metabolism, but also to significantly neutralize pathological processes in the cardiovascular area or push back the time of their occurrence to a later stage of life.

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Section:  Hypophisial Disordersmentioning

confidence: 99%

Cardiac Complications of Endocrine Diseases: A Literature Review

Воронин,

Керимова,

Хворостова

et al. 2024

Кардиология В Беларуси

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“…reported that a patient with Cushing's disease was considered to have spontaneous coronary artery dissection, which is a rare reason for AMI. 2 …”

Section: Introductionmentioning

confidence: 99%

Cushing's syndrome presenting as non‐atherosclerotic myocardial infarction and heart failure

Li,

He,

Feng

et al. 2023

ESC Heart Failure

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Cushing's syndrome is a rare cause of myocardial infarction and heart failure. Herein, we report a female patient who presented acute myocardial infarction and heart failure with reduced ejection fraction. The patient was found to have hypercortisolism secondary to adrenocortical adenoma and responded well to therapy. This case underlines the effects of hypercortisolism on the cardiovascular system. The clinical presentation of this patient is unique because non‐atherosclerotic myocardial infarction is rarely reported in Cushing's syndrome patients.

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Spontaneous Coronary Artery Dissection in a Patient With Cushing's Disease

Cited by 2 publications

References 17 publications

Cardiac Complications of Endocrine Diseases: A Literature Review

Cardiac Complications of Endocrine Diseases: A Literature Review

Cushing's syndrome presenting as non‐atherosclerotic myocardial infarction and heart failure

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