Spontaneous coronary dissection as a cause of acute coronary syndrome: Evidence for non-inflammatory underlying mechanisms

Prevalence, therapeutic management and medium-term prognosis of spontaneous coronary artery dissection: results from a database of 11,605 patients

“…Spontaneous coronary artery dissection (SCAD) is an infrequent disease, which has been found to be associated with various pathophysiological situations, such as pregnancy, postpartum, collagen diseases, cocaine abuse, severe hypertension, smoking, oral contraceptives, heavy exercise, or vasospasm [1]. It was first described in 1931 after a necropsy of a 42-year-old woman who died suddenly [2], and the first angiographic report occurred almost 50 years later, in a 55-year-old woman with acute myocardial infarction [3].…”

Spontaneous left main coronary artery dissection, possibly due to cystic medial necrosis found in the internal mammary arteries

“…1 Here we present a 55-year-old male without any coronary risk factors who developed spontaneous coronary artery dissection. Coronary artery bypass grafting (CABG) was performed using the bilateral internal mammary arteries (IMAs).…”

“…1, 2 Spontaneous coronary artery dissection is female dominant (70-78%), and among these patients, one-third occur during pregnancy or the postpartum period. 1,3 In most cases, dissection occurs without coronary risk factors or coronary atherosclerosis. 3 Most often the reported patients are healthy young to middle aged women (mean age of 40 years) without any risk factors.…”

Predictors of in-hospital mortality in coronary artery dissection: Findings from the National Inpatient Sample 2009–2010

“…CD can be SCD, traumatic (as a complication of coronary angiography) [8,9], and either atherosclerotic or non-atherosclerotic. Non-atherosclerotic SCD is associated with fibromuscular dysplasia (FMD), inflammatory and connective tissue disorders, emotional stress, exertion, post partum state and is more common in younger women [3,4,10]. Typically CD involves a single coronary artery, however multi vessel coronary artery dissection has also been reported [3].…”