1995
DOI: 10.1016/0145-2126(95)00044-o
|View full text |Cite
|
Sign up to set email alerts
|

Spontaneous cytokine overproduction by peripheral blood mononuclear cells from patients with myelodysplastic syndromes and aplastic anemia

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
27
0

Year Published

1998
1998
2010
2010

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 46 publications
(28 citation statements)
references
References 16 publications
1
27
0
Order By: Relevance
“…37,49 Increased production of IL-1␤ by blood and marrow cells has been reported. 36,50,51 Increased production of IL-1␤ by cultured marrow mononuclear cells was detected in 13/32 MDS patients. 50 Patients with RA tended to have the highest IL-1␤ production.…”
Section: Leukemiamentioning
confidence: 99%
See 1 more Smart Citation
“…37,49 Increased production of IL-1␤ by blood and marrow cells has been reported. 36,50,51 Increased production of IL-1␤ by cultured marrow mononuclear cells was detected in 13/32 MDS patients. 50 Patients with RA tended to have the highest IL-1␤ production.…”
Section: Leukemiamentioning
confidence: 99%
“…50 Patients with RA tended to have the highest IL-1␤ production. 36,50 IL-1␤ levels have been correlated with the extent of apoptosis, but not proliferation. 50 Deficient production of the IL-1␤ receptor antagonist by MDS stromal cells may give rise to unopposed apoptotic activity from IL-1␤.…”
Section: Leukemiamentioning
confidence: 99%
“…Several laboratory findings suggest that similar pathophysiologic mechanisms may also operate in hypoplastic MDS, eg higher numbers of CD8 + DR + lymphocytes, 8 increased Fas antigen expression and elevated levels of inhibitory cytokines were reported in MDS. [9][10][11] These mechanisms may be at least partially responsible for the hematopoietic failure in myelodysplasia. Similar to aplastic anemia patients, some MDS patients also respond to immunosuppressive therapy.…”
Section: Introductionmentioning
confidence: 99%
“…10,11 Several groups have shown increased tumor necrosis factor (TNF)-α levels in the marrow microenvironment and peripheral blood of MDS patients, these increased levels being an indicator of poor prognosis. [12][13][14] More recently, an overproduction of TGF-β was found in patients with advanced MDS, suggesting a pathogenic role of this potent inhibitory cytokine in MDS-associated cytopenias. 15 We have previously described a new quantitative method for the detection of anti-red blood cell (RBC) antibodies in unstimulated and mitogen-stimulated whole blood cultures, named the mitogen-stimulated direct antiglobulin test (MS-DAT).…”
mentioning
confidence: 99%