2004
DOI: 10.1016/j.pain.2004.08.026
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Spontaneous discharge and increased heat sensitivity of rat C-fiber nociceptors are present in vitro after plantar incision

Abstract: Postoperative pain is characterized by spontaneous pain at the surgical site and increased pain due to movements. To study postoperative pain mechanisms, we investigated discharge properties of mechano-heat sensitive C-fiber afferents innervating the rat glabrous hindpaw skin 1 day after plantar incision. Behaviors indicating spontaneous pain, heat and mechanical hyperalgesia were present 1 day after incision. Recording of afferents using in vitro glabrous skin-nerve preparation showed that more C-fibers from … Show more

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Cited by 62 publications
(71 citation statements)
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“…16,28 -32 Primary heat hyperalgesia is generally considered a perceptual correlate of sensitization of nociceptive afferents (peripheral sensitization). 33 In agreement, sensitization of C-fiber nociceptors after incision has been demonstrated in rats 18 and monkeys. 8 A drop in the threshold of heat-sensitive nociceptors below body temperature has been linked to spontaneous activity of C-fibers, which has been suggested to account for nonevoked resting pain under inflammatory conditions 34 but may also underlie spontaneous pain after incision.…”
Section: Somatosensory Changes At the Site Of Incision (Primary Zone)supporting
confidence: 54%
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“…16,28 -32 Primary heat hyperalgesia is generally considered a perceptual correlate of sensitization of nociceptive afferents (peripheral sensitization). 33 In agreement, sensitization of C-fiber nociceptors after incision has been demonstrated in rats 18 and monkeys. 8 A drop in the threshold of heat-sensitive nociceptors below body temperature has been linked to spontaneous activity of C-fibers, which has been suggested to account for nonevoked resting pain under inflammatory conditions 34 but may also underlie spontaneous pain after incision.…”
Section: Somatosensory Changes At the Site Of Incision (Primary Zone)supporting
confidence: 54%
“…8 A drop in the threshold of heat-sensitive nociceptors below body temperature has been linked to spontaneous activity of C-fibers, which has been suggested to account for nonevoked resting pain under inflammatory conditions 34 but may also underlie spontaneous pain after incision. 18 However, the magnitude of primary heat hyperalgesia after incision in humans did not correlate with ongoing pain in the same volunteers. This finding is supported by findings in rodents 26,27 and suggests that sensitization of different fiber types is involved in mediating ongoing pain and heat hyperalgesia after incision in humans.…”
Section: Somatosensory Changes At the Site Of Incision (Primary Zone)mentioning
confidence: 94%
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