Kink dynamics in spatially discrete nonlinear Klein-Gordon systems is considered. For special choices of the substrate potential, such systems support continuous translation orbits of static kinks with no (classical) Peierls-Nabarro barrier. It is shown that these kinks experience, nevertheless, a lattice-periodic confining potential, due to purely quantum effects anaolgous to the Casimir effect of qunatum field theory. The resulting "quantum Peierls-Nabarro potential" may be calculated in the weak coupling approximation by a simple and computationally cheap numerical algorithm, which is applied, for purposes of illustration, to a certain two-parameter family of substrates.