Spontaneous enterocutaneous fistula due to colonic malignancy: A rare case report

Jethwani, Umesh; Bansal, Ankit; Kandwal, Vipul

doi:10.4103/2278-9596.122940

Cited by 4 publications

(3 citation statements)

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“…Enterocutaneous fistula is most commonly seen after anastomotic breakdown, Crohn’s disease or diverticular abscess. Development of fistula in a patient with cancer indicates advanced stage of the disease and increases morbidity and mortality 4. The literature of such locally advanced colon carcinoma with spontaneous fistula formation with associated inflammatory skin changes is limited to a few case reports.…”

Section: Discussionmentioning

confidence: 99%

Localised perforation of locally advanced transverse colon cancer with spontaneous colocutaneous fistula formation: a clinical challenge

Wadhwani¹,

Diwakar

2018

BMJ Case Reports

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Colon cancer can present with complications such as obstruction, perforation and bleeding. The clinical presentation has been recognised as an independent prognostic factor for morbidity and mortality. We present a rare case of localised perforation of a locally advanced colon cancer arising from mid-transverse colon in an elderly woman in the absence of widely metastatic disease with eventual cutaneous involvement of the overlying skin by direct extension, resulting in formation of colocutaneous fistula. The management of such cases is complex as usually tailored to the situation encountered. This case was a clinical challenge to choose between initial palliative resection and curative R0 resection following neoadjuvant chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Localised perforation of locally advanced transverse colon cancer with spontaneous colocutaneous fistula formation: a clinical challenge

Wadhwani¹,

Diwakar

2018

BMJ Case Reports

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“…Intestinal leakage is a rare complication that is primarily associated with inflammatory bowel diseases, intestinal ulcers, intestinal tuberculosis, colorectal cancer, and abdominal surgery. The presence of a fistula in cancer patients indicates an advanced stage of the disease and increases mortality and incidence rates ( 2 ). In clinical practice, colorectal fistula is a common symptom of colon cancer.…”

Section: Introductionmentioning

confidence: 99%

Case report: POLE (P286R) mutation in a case of recurrent intestinal leakage and its treatment

Xiang

Chen

et al. 2023

Front. Oncol.

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In recent years, although new drugs and molecular markers have been used to treat metastatic colorectal cancer, there has been little progress in the immunotherapy of advanced colon cancer. The development of sequencing and multiomics technology helps us classify patients more accurately, and then find patients who may benefit from immunotherapy. The development of this advanced technology and immunotherapy based on new targets may herald a new era in the treatment of metastatic colorectal cancer. It is well known that colorectal cancer with dmmr/msi-h phenotype is sensitive to immunotherapy, yet the POLE mutation is the MSS phenotype in colorectal tumors but is also an effective target for immunotherapy. This paper describes a case of recurrent intestinal leakage that required multiple surgical procedures. A high-grade colon adenocarcinoma was identified on surgical histopathology after 18 months, and bevacizumab combined with oxaliplatin and capecitabine proved ineffective against this cancer. An analysis of gene expression indicated that POLE (P286R) mutation, TMB 119.333 mutation per 100 MB, and immune checkpoint inhibitor treatment had a significant impact. This case reminds us that the existence of malignant tumors should be considered for patients with repeated intestinal leakage, and emphasizes the importance of gene detection in the treatment of malignant tumors and the significance of POLE mutations in colorectal cancer.

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“…ECF is only ever associated with colorectal cancer [6] and when present, it signifies a locally advanced disease. Colon cancers presenting as ECF are rare, only few case reports have been published so far as to our best knowledge [2] , [6] , [7] , [8] , [9] . Such presentation of colonic carcinoma poses a difficulty in management in terms of patient optimization, determining the type of resection (palliative vs curative) and the operative timeline.…”

Section: Introductionmentioning

confidence: 99%

Colorectal carcinoma presenting as spontaneous colocutaneous fistula - A rare case report and review of literature

Basukala

Khand²,

Pahari³

et al. 2022

International Journal of Surgery Case Reports

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Spontaneous enterocutaneous fistula due to colonic malignancy: A rare case report

Cited by 4 publications

References 0 publications

Localised perforation of locally advanced transverse colon cancer with spontaneous colocutaneous fistula formation: a clinical challenge

Localised perforation of locally advanced transverse colon cancer with spontaneous colocutaneous fistula formation: a clinical challenge

Case report: POLE (P286R) mutation in a case of recurrent intestinal leakage and its treatment

Colorectal carcinoma presenting as spontaneous colocutaneous fistula - A rare case report and review of literature

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