Spontaneous Erythroleukemia in a 16-Wk-Old Female Slc:SD Rat

Nonoyama, Takashi; Hayashi, Shim-mo; Urano, Takashi; Yagami, Ken‐ichi; Miyajima, Hiroaki

doi:10.1177/019262339302100310

Cited by 9 publications

(7 citation statements)

References 9 publications

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“…The present mouse case closely resembled "pure erythroid leukemia" in humans. In addition, the pathological nature of the present case was similar to that of the first case of mouse erythroleukemia reported by Frith et al 6 . This suggests that the so-called "pure erythroid leukemia" may be the predominant phenotype of erythroid leukemia in mice, although further study is required.…”

Section: 3supporting

confidence: 88%

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Spontaneous Erythroid Leukemia in a 6-Wk-Old Male Crlj:B6C3F1 Mouse

2007

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This report describes spontaneous occurrence of erythroid leukemia in a 6 week-old male Crlj:B6C3F 1 mouse. Macroscopically, severe hepatosplenomegaly was noted, but no abnormalities were observed in other tissues including the thymus and lymph nodes. Hematological examinations of blood and bone marrow smear preparations revealed marked proliferation of erythroid cells at various stages of maturation, but neither obvious atypia nor neoplastic proliferation of granulocytic cells was observed. Microscopically, there was marked infiltration of neoplastic erythroid cells into the hepatic sinusoids, splenic red pulp, and bone marrow, but there was no infiltration into the thymus or lymph nodes. Corresponding to the hematological findings, no distinct proliferation of granulocytic cells was detected microscopically. Immunohistochemical examination revealed that these cells were positive for hemoglobin. The present case of mouse erythroid leukemia closely resembles "pure erythroid leukemia" in humans. (J Toxicol Pathol 2007; 20: 101-104)

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Section: 3supporting

confidence: 88%

“…The first cases of spontaneous erythroleukemia were reported in a mouse and rat by Frith et al (1990) 1 and Nonoyama et al (1993) 6 , respectively. Since then, there have been no other reports of spontaneous murine erythroid leukemia.…”

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Spontaneous Erythroid Leukemia in a 6-Wk-Old Male Crlj:B6C3F1 Mouse

2007

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“…These findings were almost consistent with the features of erythroid leukemia reported previously in a rat 4 . However, one difference from previous reports was that there were numerous spindle-shaped neoplastic erythroblastic cells.…”

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confidence: 91%

“…It is known that erythroid leukemia can be induced in rats by administration of 7,8,12-trimethyl-benz[a]anthracene and nitrosoureas, but spontaneous erythroid leukemia is extremely rare in rats 1 . To our knowledge, only one case, involving a 16-week-old female Slc:SD rat, has been reported 4 . In this report, we describe the histological and immunohistochemical characteristics of a new case of spontaneous erythroid leukemia in a younger rat.…”

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confidence: 98%

“…Erythroid leukemia or erythroleukemia is a myeloproliferative disorder characterized by an excessive proliferation of erythrogenic cells 1 – 4 . It is known that erythroid leukemia can be induced in rats by administration of 7,8,12-trimethyl-benz[a]anthracene and nitrosoureas, but spontaneous erythroid leukemia is extremely rare in rats 1 .…”

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Spontaneous Erythroid Leukemia in a 7-Week-Old Crl:CD (SD) Rat

et al. 2010

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A young male Crl:CD (SD) rat with erythroid leukemia that presented with emaciation, abdominal distension and a pale visible mucosal membrane was euthanized at 7 weeks of age. At necropsy, enlargement of liver, spleen and pancreatic lymph node was noted. Analysis of blood smear samples revealed many mono- or binucleated erythroblasts that had PAS-positive vacuoles in the cytoplasm. Histopathologically, neoplastic proliferation of atypical cells was observed in the hepatic sinusoids, splenic red pulp, bone marrow, pancreatic lymph node, kidney and lung. Neoplastic cells showed a round to spindle shape, and some neoplastic cells had deeply stained small nuclei and small cytoplasms and resembled erythroblasts. Immunohistochemically, many neoplastic cells were positive for hemoglobin. To our knowledge, this is the first report of erythroid leukemia in a rat of this age. The observed features were similar to those of pure erythroid leukemia in humans.

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Hemopoietic and Lymphatic Systems

Greaves¹

2012

Histopathology of Preclinical Toxicity Studies

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Spontaneous Erythroleukemia in a 16-Wk-Old Female Slc:SD Rat

Cited by 9 publications

References 9 publications

Spontaneous Erythroid Leukemia in a 6-Wk-Old Male Crlj:B6C3F1 Mouse

Spontaneous Erythroid Leukemia in a 6-Wk-Old Male Crlj:B6C3F1 Mouse

Spontaneous Erythroid Leukemia in a 7-Week-Old Crl:CD (SD) Rat

Hemopoietic and Lymphatic Systems

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