Spontaneous Extraskeletal Osteosarcomas of the Subcutis in Djungarian hamsters (<i>Phodopus sungorus</i>): Report of two cases

Madarame, Hiroo; Itoh, Akira; Hirose, Miyoko; Ogihara, Kikumi

doi:10.1111/j.1439-0442.2004.00635.x

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…Hamsters are popular as pets, Chinese hamsters ( Cricetulus griseus ) being the most common. Reports on spontaneous tumors in domestic hamsters are scarce, and most are individual case reports …”

Section: Discussionmentioning

confidence: 99%

“…Based on the cytologic and histologic patterns (osseous differentiation, no association with normal bones), the diagnosis was extraskeletal osteosarcoma. Extraskeletal osteosarcoma, a rare malignant mesenchymal neoplasm, produces osseous tissue that is not attached to the skeleton in people and has previously been reported in dogs, cats, hamsters, and rats …”

Section: Discussionmentioning

confidence: 99%

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What is your diagnosis? Scapular mass in a Chinese hamster

Conrado

Bruno

Alencar

2013

Veterinary Clinical Pathol

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A one-year-old Chinese hamster (Cricetulus griseus) was presented at the Small Animal Hospital of the Universidade Federal Fluminense for lethargy and a 3-cm-wide subcutaneous, firm, mobile round mass in the left scapular region. Radiographs revealed a soft tissue density mass of homogenous radiopacity with no connection to underlying bone, but no evidence for pulmonary metastases. A fine-needle aspirate was performed; the cytologic appearance of the mass is presented in Figures 1A,B. Two days after aspiration, the mass was excised and submitted for histopathology. A B Figure 1. Fine-needle aspirate from scapular mass in a hamster. Giemsa. (A) 9100 objective. (B) 910 objective.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

What is your diagnosis? Scapular mass in a Chinese hamster

Conrado

Bruno

Alencar

2013

Veterinary Clinical Pathol

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“…ESOs have also been reported in dogs, cats 2 , hamsters 3 , rabbits 4 and rats 5–10 . We encountered a case of spontaneous ESO with pulmonary metastasis in an aged female F344 rat.…”

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confidence: 91%

Extraskeletal Osteosarcoma with Pulmonary Metastasis in a Female F344 Rat

et al. 2011

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A subcutaneous mass in the right femoral region of a female F344 Slc/N rat was examined histopathologically. At 83 weeks of age, the animal showed symptoms of severe anemia and nasal bleeding. Necropsy revealed that the mass had invaded the skeletal muscles but did not affect the bones. Multicentric nodules were also observed in the lung. Histopathology revealed a sheet-like growth pattern of polygonal tumor cells with round or comma-shaped nuclei and pale eosinophilic cytoplasm. Osteoid tissue was observed in not only the original lesion but also the metastatic foci in the lung. Each tumor cell was surrounded by argentophil fibers and few collagen fibers. Immunohistochemically, the tumor cells were positive for proliferating cell nuclear antigen (PCNA), vimentin, osterix and osteocalcin, but negative for keratin, S-100, von Willebrand factor, CD-31, CD-34, desmin, α-smooth muscle actin, lysozyme, α1-antitrypsin and rat malignant fibrous histiocytoma (MFH) antigen. CD-68-positive cells were considered to be infiltrated macrophages because they were negative for PCNA. On the basis of these findings, we diagnosed the present case as extraskeletal osteosarcoma.

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“…Extraskeletal osteosarcoma (ESOS) is a rare malignant mesenchymal neoplasm, which is never attached to the skeleton, although the histopathological characteristics such as osteoid and bone formation are similar to those of bone-derived osteosarcomas 5 , 6 . ESOS has been reported in dogs, cats, hamsters, a rat, a hedgehog, a maned wolf and a goat as an infrequent tumor 7 , 8 , 9 , 10 , 11 , 12 .…”

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confidence: 99%

Spontaneous Extraskeletal Osteosarcoma in a Rabbit (<i>Oryctolagus cuniculus</i>): Histopathological and Immunohistochemical Findings

Wijesundera

Izawa

Fujita³

et al. 2013

J Toxicol Pathol

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A spontaneously occurring subcutaneous mass in the left forelimb of a nine-year-old rabbit (Oryctolagus cuniculus) was examined histopathologically and immunohistochemically. Clinically, edema and hemorrhage were seen around the mass. No connection of the tumor mass to the appendicular skeleton was found. The tumor was arranged in a solid growth pattern and irregular bundles, and neoplastic cells were polygonal to spindle-shape. Osteoid (positive for osteocalcin) and multinucleated giant cells were diffusely or focally seen. Neoplastic cells were positive for vimentin, osterix and Ki-67, indicating the nature of osteoblasts with proliferating activity, but negative for α-smooth muscle actin, desmin or CD204. Based on these findings, a diagnosis of extraskeletal osteosarcoma was made, a very rare tumor both in laboratory and pet rabbits.

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Spontaneous Extraskeletal Osteosarcomas of the Subcutis in Djungarian hamsters (Phodopus sungorus): Report of two cases

Cited by 4 publications

References 8 publications

What is your diagnosis? Scapular mass in a Chinese hamster

What is your diagnosis? Scapular mass in a Chinese hamster

Extraskeletal Osteosarcoma with Pulmonary Metastasis in a Female F344 Rat

Spontaneous Extraskeletal Osteosarcoma in a Rabbit (<i>Oryctolagus cuniculus</i>): Histopathological and Immunohistochemical Findings

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