Spontaneous extrusion of porous amphiphilic triblock copolymeric microfibers under microfluidic conditions

Marimuthu, Mohana; Kim, Sang-Hyo

doi:10.1038/pj.2009.301

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…Solvent exchange is another common method for fabricating porous microfibers. ,, Typically, an inner polymer solution (the core solution) is introduced into an outer nonsolvent liquid (the sheath solution) to form a continuous liquid jet. − The contact between the two liquids induces diffusion-controlled mass transfer between the core and sheath solutions. Solvent exchange leads to polymer precipitation, which solidifies the core liquid jets into porous polymeric microfibers.…”

Section: Tailoring Wettability Of Microfibers From Liquid Jetsmentioning

confidence: 99%

Microfluidics-Enabled Soft Manufacture of Materials with Tailorable Wettability

Zhu

Wang

2021

Chem. Rev.

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Microfluidics and wettability are interrelated and mutually reinforcing fields, experiencing synergistic growth. Surface wettability is paramount in regulating microfluidic flows for processing and manipulating fluids at the microscale. Microfluidics, in turn, has emerged as a versatile platform for tailoring the wettability of materials. We present a critical review on the microfluidics-enabled soft manufacture (MESM) of materials with well-controlled wettability and their multidisciplinary applications. Microfluidics provides a variety of liquid templates for engineering materials with exquisite composition and morphology, laying the foundation for precisely controlling the wettability. Depending on the degree of ordering, liquid templates are divided into individual droplets, one-dimensional (1D) arrays, and two-dimensional (2D) or three-dimensional (3D) assemblies for the modular fabrication of microparticles, microfibers, and monolithic porous materials, respectively. Future exploration of MESM will enrich the diversity of chemical composition and physical structure for wettability control and thus markedly broaden the application horizons across engineering, physics, chemistry, biology, and medicine. This review aims to systematize this emerging yet robust technology, with the hope of aiding the realization of its full potential.

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Section: Tailoring Wettability Of Microfibers From Liquid Jetsmentioning

confidence: 99%

Microfluidics-Enabled Soft Manufacture of Materials with Tailorable Wettability

Zhu

Wang

2021

Chem. Rev.

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“…[28] Furthermore, the drug-eluting fiber can be made out of suspension by electrospinning, [193] wet spinning, [194] or microfluidic spinning. [195][196][197] In wet spinning and microfluidic spinning, encapsulation efficiency dramatically depends on the type of antisolvent used to regenerate and solidify the fibers as it might lead to partial dissolution of the drug. [106,194,195] Wu et al [198] fabricated microfibers made of polyacrylonitrile (PAN) encapsulated with curcumin and vitamin E acetate.…”

Section: Encapsulationmentioning

confidence: 99%

Drug‐Eluting Medical Textiles: From Fiber Production and Textile Fabrication to Drug Loading and Delivery

Rostamitabar

Abdelgawad

Jockenhoevel

et al. 2021

Macromolecular Bioscience

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Drug-eluting medical textiles have recently gained great attention to be used in different applications due to their cost effectiveness and unique physical and chemical properties. Using various fiber production and textile fabrication technologies, fibrous constructs with the required properties for the target drug delivery systems can be designed and fabricated. This review summarizes the current advances in the fabrication of drug-eluting medical textiles. Different fiber production methods such as melt-, wet-, and electro-spinning, and textile fabrication techniques such as knitting and weaving are explained. Moreover, various loading processes of bioactive agents to obtain drug-loaded fibrous structures with required physicochemical and morphological properties, drug delivery mechanisms, and drug release kinetics are discussed. Finally, the current applications of drug-eluting fibrous systems in wound care, tissue engineering, and transdermal drug delivery are highlighted.

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“…The drug has to be administered less frequently to the patient because of the sustained release of the drug . This sustained release resembles the flat portion of the separate plots depicted in Figure (b) . The release rates and the time at which the release rate plateaus out depend on the drug molecule, the concentration of the drug molecule in the fiber, and the nature of the fiber itself. − , Luu et al incorporated DNA into a fibrous scaffold made by PLGA and PLA–PEG block copolymers.…”

Section: Electrospinningmentioning

confidence: 99%

“…(a) A schematic depicting the burst-effect in a zero order controlled drug delivery . (b) The release profiles of protein and dye in DMSO (dimethyl sulfoxide) and dichloromethane from microfluidically fabricated fibers . (c) The release profiles of tetracycline hydrochloride (TCH) from electrospun TH-1/PLGA, TH-2/PLGA, tetracycline hydrochloride loaded/poly(lactic- co -glycolic acid) composite (TCH/PLGA) nanofibers, and tetracycline hydrochloride loaded halloysite nanotubes (TCH/HNT) fibers .…”

Section: Electrospinningmentioning

confidence: 99%

Fiber Based Approaches as Medicine Delivery Systems

Sharifi

Sooriyarachchi

Altural

et al. 2016

ACS Biomater. Sci. Eng.

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The goal of drug delivery is to ensure that therapeutic molecules reach the intended target organ or tissue, such that the effectiveness of the drug is maximized. The efficiency of a drug delivery system greatly depends on the choice of drug carrier. Recently, there has been growing interest in using micro-and nanofibers for this purpose. The reasons for this growing interest include these materials' high surface area to volume ratios, ease of fabrication, high mechanical properties, and desirable drug release profile. Here, we review developments in using these materials made by the most prevalent methods of fiber fabrication: electrospinning, microfluidics, wet spinning, rotary spinning, and self-assembly for drug delivery purposes. Additionally, we discuss the potential to use these fiber based systems in research and clinical applications.

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Spontaneous extrusion of porous amphiphilic triblock copolymeric microfibers under microfluidic conditions

Cited by 9 publications

References 6 publications

Microfluidics-Enabled Soft Manufacture of Materials with Tailorable Wettability

Microfluidics-Enabled Soft Manufacture of Materials with Tailorable Wettability

Drug‐Eluting Medical Textiles: From Fiber Production and Textile Fabrication to Drug Loading and Delivery

Fiber Based Approaches as Medicine Delivery Systems

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