Spontaneous firing of nigrostriatal dopaminergic neurons in split-brain rats

Castellano, Miguel A.; Rivero, Francisco; Rodrı́guez, Manuel

doi:10.1016/0304-3940(93)90545-v

Cited by 18 publications

(12 citation statements)

References 25 publications

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“…About 20 -25% of DMN cells showed projections to the thalamus or colliculus of the contralateral brain, a proportion that is much lower in the SN (Ͻ5%). Direct projections have not been found between right-SN and left-SN (Gerfen et al, 1982), but there is experimental evidence showing a functional relationship between both (Niequllon et al, 1977;Anderson et al, 1980;Rodriguez et al, 1990Rodriguez et al, , 1994Castellano and Rodriguez, 1991;Castellano et al, 1993) that is involved in behavioral lateralization (Diaz-Palarea et al, 1987;Castellanos et al, 1989;Rodriguez et al, 1992). The bilateral projection of the DMN could be an appropriate mechanism for this interhemispheric regulation, especially with the knowledge that, in addition to these cross fibers, DMN receives inputs from the ipsilateral striatum and SN (Veazey and Severin, 1982) and sends outputs to the contralateral DMN (Veazey and Severin, 1982).…”

Section: Discussionmentioning

confidence: 95%

“…A total of 30 rats were anaesthetized with chloral hydrate (400 mg/kg i.p.) and, using a procedure previously reported (Castellano et al, 1993;Rodríguez and Barroso, 1996;Rodríguez and Gonzá lez-Herná ndez, 1999), the extracellular activity of the DMN and of SN neurons was monitored. Briefly, cell activity was recorded with glass electrodes filled with 2 M NaCl containing 2% Pontamine Sky Blue (6 -9 M⍀ at 1000 Hz).…”

Section: Electrophysiological Studymentioning

confidence: 99%

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The deep mesencephalic nucleus as an output center of basal ganglia: Morphological and electrophysiological similarities with the substantia nigra

Rodrı́guez

Abdala

Barroso‐Chinea

et al. 2001

J of Comparative Neurology

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The deep mesencephalic nucleus (DMN) is a large midbrain reticular region between the superior colliculus, the substantia nigra compacta, the periaqueductal gray, and the medial geniculate body. Although some data suggest that it is involved in nociception and visceral control, its functions remain unclear. In the present study, by using morphological (combination of anterograde and retrograde tracers with immunocytochemistry and in situ hibrydization) and electrophysiological (firing activity and transynaptic response to striatal stimulation) methods, we show that a subpopulation of DMN cells shares many morphological and electrophysiological characteristics with those of the substantia nigra reticulata (SNR). These similarities include the following: 1) firing rate, firing pattern, and conduction velocity; 2) expression of GAD65, GAD67, and PV; 3) excitatory and inhibitory inputs from the striatum; and 4) projections to the ventral thalamus, superior colliculus, and pedunculopontine tegmental nucleus. Some differences were also found. In comparison with SN, DMN cells and striatal afferents are more sparsely distributed and they show conspicuous contralateral projections to the thalamus and superior colliculus. This suggests that, similarly to the SNR, the DMN acts as an output center of basal ganglia and probably facilitates the inter-hemispheric regulation of these centers.

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Section: Discussionmentioning

confidence: 95%

Section: Electrophysiological Studymentioning

confidence: 99%

The deep mesencephalic nucleus as an output center of basal ganglia: Morphological and electrophysiological similarities with the substantia nigra

Rodrı́guez

Abdala

Barroso‐Chinea

et al. 2001

J of Comparative Neurology

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“…Four weeks after the lesion, rats were anesthetized with 400 mg/kg chloral hydrate administered intraperitoneally and, using a procedure previously reported, 13,14 the extracellular activity of SN neurons was monitored. 15 Briefly, animals were mounted in a stereotaxic apparatus and once the scalp was reflected, the skull overlying the right or left substantia nigra was removed.…”

Section: Methodsmentioning

confidence: 99%

Excitatory responses in the ?direct? striatonigral pathway: Effect of nigrostriatal lesion

2000

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“…Previous studies in animal models provoking acute or chronic unilateral lesion of the dopaminergic nigrostriatal system have shown a reciprocal interaction between the intact and DA-depleted striatum (Nieoullon et al, 1977; Andersson et al, 1980; Van Camp et al, 2010). Some previous reports studying the effects of unilateral and bilateral partial lesions of the nigrostriatal system in 6-hydroxydopamine (6-OHDA) rats suggested an interdependent regulation of the two nigrostriatal systems, which could provide some compensatory support for the lesioned hemisphere (Rodriguez et al, 1990; Castellano et al, 1993; Roedter et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

Inter-hemispheric asymmetry of nigrostriatal dopaminergic lesion: a possible compensatory mechanism in Parkinson’s disease

Blesa

Juri

García‐Cabezas

et al. 2011

Front. Syst. Neurosci.

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The onset of Parkinson’s disease (PD) is characterized by focal motor features in one body part, which are usually correlated with greater dopaminergic depletion in the contralateral posterior putamen. The role of dopamine (DA) hemispheric differences in the onset and progression of motor symptoms of PD, however, remains undefined. Previous studies have demonstrated that unilateral manipulations of one nigrostriatal system affect contralateral DA turnover, indicating a functional and compensatory inter-dependence of the two nigrostriatal systems. In preliminary data obtained by our group from asymmetric PD patients, a higher asymmetry index as measured by 6-[18F]fluoro-L-dopa (18 F-DOPA) positron emission tomography (PET) was associated with a higher threshold (i.e., greater dopaminergic loss) for the onset of motor symptoms in the less-affected side. To further elucidate the underlying basis for this, we carried out a complementary study in monkeys using PET to assess and correlate the degree of dopaminergic striatal depletion with motor activity. Control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated monkeys with symmetrical lesions were characterized behaviorally and with 18F-DOPA PET. In parallel, an acute lesion was inflicted in the nigrostriatal projection unilaterally in one monkey, generating a 30% dopaminergic depletion in the ipsilateral striatum, which was not associated with any noticeable parkinsonian feature or deficit. The monkey remained asymptomatic for several months. Subsequently, this monkey received systemic MPTP, following which motor behavior and PET were repeatedly evaluated during progression of parkinsonian signs. The brains of all monkeys were processed using immunohistochemical methods. Our results suggest that the onset of motor signs is related to and influenced by the dopaminergic status of the less-affected, contralateral striatum. Although this work is still preliminary, the study agrees with our general hypothesis of hemispheric inter-dependence in the compensation of striatal DA deficit in PD.

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Spontaneous firing of nigrostriatal dopaminergic neurons in split-brain rats

Cited by 18 publications

References 25 publications

The deep mesencephalic nucleus as an output center of basal ganglia: Morphological and electrophysiological similarities with the substantia nigra

The deep mesencephalic nucleus as an output center of basal ganglia: Morphological and electrophysiological similarities with the substantia nigra

Excitatory responses in the ?direct? striatonigral pathway: Effect of nigrostriatal lesion

Inter-hemispheric asymmetry of nigrostriatal dopaminergic lesion: a possible compensatory mechanism in Parkinson’s disease

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