Spontaneous Formation of RNA Strands, Peptidyl RNA, and Cofactors

Jauker, Mario; Grießer, Helmut; Richert, Clemens

doi:10.1002/anie.201506593

Cited by 76 publications

(110 citation statements)

References 46 publications

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“…As a first choice, the nucleotide should be adenine, and the amino acid attached through a phosphoramidate link. The phosphoramidate link forms as shown by Richert and co-workers (Jauker et al, 2015). Aminoacyl-AMP can also be formed with an anhydride link, as used in the activation of amino acids in contemporary metabolism.…”

Section: The Coding Coenzyme Handle Hypothesismentioning

confidence: 90%

“…Ribozymes could grab the adenine attached functional molecules through the adenine (Jadhav and Yarus, 2002;Saran et al, 2003). Adenine (AMP) seems to be the only among the four canonical bases that can easily form coenzymes (Jauker et al, 2015), by condensing with a functional molecule. Furthermore, not only nicotinamide mononucleotide or flavin mononucleotide can be condensed with AMP to yield the coenzyme NAD + and FAD, respectively, but peptides also condensate readily (Jauker et al, 2015).…”

Section: The Coding Coenzyme Handle Hypothesismentioning

confidence: 99%

“…Adenine (AMP) seems to be the only among the four canonical bases that can easily form coenzymes (Jauker et al, 2015), by condensing with a functional molecule. Furthermore, not only nicotinamide mononucleotide or flavin mononucleotide can be condensed with AMP to yield the coenzyme NAD + and FAD, respectively, but peptides also condensate readily (Jauker et al, 2015). adenine-conjugates could have been present in the primordial environment employed by the metabolism of the ribocells.…”

Section: The Coding Coenzyme Handle Hypothesismentioning

confidence: 99%

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The evolution of the genetic code: Impasses and challenges

Kun

Radványi

2018

Biosystems

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The origin of the genetic code and translation is a "notoriously difficult problem". In this survey we present a list of questions that a full theory of the genetic code needs to answer. We assess the leading hypotheses according to these criteria. The stereochemical, the coding coenzyme handle, the coevolution, the four-column theory, the error minimization and the frozen accident hypotheses are discussed. The integration of these hypotheses can account for the origin of the genetic code. But experiments are badly needed. Thus we suggest a host of experiments that could (in)validate some of the models. We focus especially on the coding coenzyme handle hypothesis (CCH). The CCH suggests that amino acids attached to RNA handles enhanced catalytic activities of ribozymes. Alternatively, amino acids without handles or with a handle consisting of a single adenine, like in contemporary coenzymes could have been employed. All three scenarios can be tested in in vitro compartmentalized systems.

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Section: The Coding Coenzyme Handle Hypothesismentioning

confidence: 90%

Section: The Coding Coenzyme Handle Hypothesismentioning

confidence: 99%

Section: The Coding Coenzyme Handle Hypothesismentioning

confidence: 99%

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The evolution of the genetic code: Impasses and challenges

Kun

Radványi

2018

Biosystems

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“…We should refrain from intuitively assuming that there is only "one way to RomeNA" ,a nd we are certain that with further progress in prebiotic systems chemistry,w here new synergies from mixing different prebiotic compound classes are being discovered, [15] organic chemists are looking into ab righter future than we have ever been able to imagine. [3] …”

Section: Methodsmentioning

confidence: 99%

Bringing Prebiotic Nucleosides and Nucleotides Down to Earth

Fiore

Strazewski

2016

Angew Chem Int Ed

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There may be more than one way leading to RNA: Recent discoveries in the synthesis of nucleoside and nucleotide precursors are described and put into the wider context of prebiotic systems chemistry. Mixing Butlerow's carbohydrate precursors with Traube's 5-formylaminopyrimidines has led to the formation of prebiotic purine nucleosides whereas the mixing of 5-phosphoribose with barbituric acid and melamine gave supramolecular fibers from stacks of Whitesides' rosettas.

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“…[23] [*] Dipl. [23] Angewandte Chemie Formation of peptido RNA from amino acids and ribonucleotides.…”

mentioning

confidence: 99%

Amino Acid‐Specific, Ribonucleotide‐Promoted Peptide Formation in the Absence of Enzymes

et al. 2016

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Nucleic acids and polypeptides are at the heart of life.I ti si nteresting to ask whether the monomers of these biopolymers possess intrinsic reactivity that favors oligomerization in the absence of enzymes.W eh ave recently observed that covalently linked peptido RNAchains form when mixtures of monomers react in salt-rich condensation buffer.H ere,w e report the results of as creen of the 20 proteinogenic amino acids and four ribonucleotides.N one of the amino acids prevent phosphodiester formation, so all of them are compatible with genetic encoding through RNAc hain growth. A reactivity landscape was found, in whichp eptide formation strongly depends on the structure of the amino acid, but less on the nucleobase.F or example,p roline gives ribonucleotidebound peptides most readily,t yrosine favors pyrophosphate and phosphodiester formation, and histidine gives phosphorimidazolides as dominant products.When proline and aspartic acid were allowed to compete for incorporation, only proline was found at the N-terminus of peptido chains.T he reactivity described here links two fundamental classes of biomolecules through reactions that occur without enzymes,but with amino acid specificity.

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Spontaneous Formation of RNA Strands, Peptidyl RNA, and Cofactors

Cited by 76 publications

References 46 publications

The evolution of the genetic code: Impasses and challenges

The evolution of the genetic code: Impasses and challenges

Bringing Prebiotic Nucleosides and Nucleotides Down to Earth

Amino Acid‐Specific, Ribonucleotide‐Promoted Peptide Formation in the Absence of Enzymes

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