Anterolisthesis is a condition where a vertebra in the spine slips forward relative to the vertebra below it. Anterolisthesis is often described in terms of the direction of the slippage and the affected vertebrae, such as L5-S1 anterolisthesis, which indicates the slippage occurring between the fifth lumbar vertebra (L5) and the sacral bone (S1). Anterolisthesis can result from various factors, trauma, or congenital abnormalities. The symptoms associated with anterolisthesis can include lower back pain, stiffness, muscle tightness, and neurological symptoms if the slippage compresses nearby nerves. The piriformis muscle, situated deep within the buttocks, plays a crucial role in this scenario, as its contraction or inflammation can exacerbate the compression of the sciatic nerve, intensifying the pain and discomfort experienced by the individual. Patients with L5-S1 anterolisthesis and bilateral piriformis syndrome commonly report challenges in daily activities involving hip movement, such as walking, sitting, or standing for prolonged periods of time. The combined effects of vertebral slippage and piriformis involvement contribute to altered gait patterns and may lead to difficulties in maintaining a stable and pain-free posture. Effective management often necessitates a comprehensive approach, encompassing physical therapy, pain management strategies, and, in severe cases, surgical intervention. We report a case of a 75-year-old male who complained of pain in his back radiating to both lower limbs with a history of slipping and falling in the bathroom one month prior, sustaining an injury to his back, and who visited the orthopedics department of Acharya Vinoba Bhave Rural Hospital (AVBRH), Sawangi, Wardha, where an investigation was done and an X-ray revealed L5-S1 anterolisthesis. Physiotherapy plays a crucial role in reducing pain, improving the range of motion and muscle strength, decreasing muscle tightness, and enhancing the quality of life. The goal of physiotherapeutic rehabilitation for L5-S1 anterolisthesis management is to optimize functional recovery, reduce pain, improve the range of motion and muscle strength, and improve the overall quality of life for individuals with this condition.