Spontaneous gastroduodenal perforations in dogs — a retrospective study of 15 cases

Cariou, M P L; Lipscomb, Victoria; Brockman, Daniel J.; Gregory, Susan

doi:10.1136/vr.165.15.436

Cited by 28 publications

(43 citation statements)

References 19 publications

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“…14-16 While less common, masses, both benign and neoplastic as well as a variety of inflammatory lesions of the duodenum have been reported in the literature. [17][18][19][20][21][22][23] Positional survey radiography may provide an inexpensive, readily available method for further evaluating some of these lesions.…”

Section: Discussionmentioning

confidence: 99%

Initial Influence of Right Versus Left Lateral Recumbency on the Radiographic Finding of Duodenal Gas on Subsequent Survey Ventrodorsal Projections of the Canine Abdomen

Hart

Berry

2014

Vet Radiology Ultrasound

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Identification of the duodenum and potential abnormalities on survey abdominal radiographs is often difficult unless it contains gas. This study investigated the effect of patient positioning on the presence of duodenal gas in survey abdominal radiographs. One hundred dogs receiving a three-view survey abdominal radiographic study were enrolled in a prospective, randomized study where all dogs were divided into two groups. Group A (n = 51) dogs had a left lateral projection first, followed by a ventrodorsal projection, ending with a right lateral projection. Group B (n = 49) dogs had a right lateral projection first, followed by a ventrodorsal projection, ending with a left lateral projection. The presence of gas within the duodenum and level of distribution of gas throughout the duodenum were recorded for all three projections. In addition, the presence or absence of duodenal pseudoulcers was evaluated on all three projections for each dog. The results for the two groups were compared using Chi-square analysis with a P-value of less than 0.05 being considered significant. Results showed that dogs first placed in left lateral recumbency were significantly more likely to have duodenal gas on the subsequent ventrodorsal and right lateral radiographic projections compared to dogs first placed in right lateral recumbency (P-value < 0.0001). Pseudoulcers were seen in 11 dogs that had duodenal gas making the visualization of pseudoulcers on survey abdominal radiographs somewhat commonplace. This study emphasizes the benefit of using initial left lateral abdominal projections prior to other views for subsequent evaluation of the duodenum.

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Section: Discussionmentioning

confidence: 99%

Initial Influence of Right Versus Left Lateral Recumbency on the Radiographic Finding of Duodenal Gas on Subsequent Survey Ventrodorsal Projections of the Canine Abdomen

Hart

Berry

2014

Vet Radiology Ultrasound

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“…Enterohepatic recycling of NSAIDs likely plays a role whereby high concentrations of NSAIDs in bile are secreted into the duodenum in close proximity to the major duodenal papilla. Some of the most serious intestinal lesions in dogs caused by NSAIDs occur in this region . Small intestinal injury may be caused by increased numbers of gram‐negative facultative anaerobic bacteria that flourish in the SI of patients treated with PPIs.…”

Section: Mechanism Of Action Biological Targets Efficacy Adverse Ementioning

confidence: 99%

ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats

Marks

Kook

Papich

et al. 2018

Veterinary Internal Medicne

102

177

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The gastrointestinal (GI) mucosal barrier is continuously exposed to noxious toxins, reactive oxygen species, microbes, and drugs, leading to the development of inflammatory, erosive, and ultimately ulcerative lesions. This report offers a consensus opinion on the rational administration of GI protectants to dogs and cats, with an emphasis on proton pump inhibitors (PPIs), histamine type‐2 receptor antagonists (H2RAs), misoprostol, and sucralfate. These medications decrease gastric acidity or promote mucosal protective mechanisms, transforming the management of dyspepsia, peptic ulceration, and gastroesophageal reflux disease. In contrast to guidelines that have been established in people for the optimal treatment of gastroduodenal ulcers and gastroesophageal reflux disease, effective clinical dosages of antisecretory drugs have not been well established in the dog and cat to date. Similar to the situation in human medicine, practice of inappropriate prescription of acid suppressants is also commonplace in veterinary medicine. This report challenges the dogma and clinical practice of administering GI protectants for the routine management of gastritis, pancreatitis, hepatic disease, and renal disease in dogs and cats lacking additional risk factors for ulceration or concerns for GI bleeding. Judicious use of acid suppressants is warranted considering recent studies that have documented adverse effects of long‐term supplementation of PPIs in people and animals.

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“…Gastrointestinal (GI) ulceration in dogs is a well-recognised condition that may occur following administration of antiinflammatory drugs (Stanton & Bright 1989, Lascelles et al 2005, Enberg et al 2006, Cariou et al . 2009, Dayer et al .…”

Section: Introductionmentioning

confidence: 99%

Clinical findings and results of diagnostic imaging in 82 dogs with gastrointestinal ulceration

Fitzgerald

Barfield

Lee

et al. 2017

J of Small Animal Practice

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Spontaneous gastroduodenal perforations in dogs — a retrospective study of 15 cases

Cited by 28 publications

References 19 publications

Initial Influence of Right Versus Left Lateral Recumbency on the Radiographic Finding of Duodenal Gas on Subsequent Survey Ventrodorsal Projections of the Canine Abdomen

Initial Influence of Right Versus Left Lateral Recumbency on the Radiographic Finding of Duodenal Gas on Subsequent Survey Ventrodorsal Projections of the Canine Abdomen

ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats

Clinical findings and results of diagnostic imaging in 82 dogs with gastrointestinal ulceration

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