Spontaneous gastrosplenic fistula secondary to primary splenic lymphoma

Khan, Faraan; Vessal, Sheida; McKimm, Eister; D’Souza, Raymond

doi:10.1136/bcr.04.2010.2932

Cited by 20 publications

(9 citation statements)

References 16 publications

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“…Most of them presented with abdominal pain, splenomegaly, vomiting and fatigue. Some others presented with hematemesis or melena and epigastric pain [7]. These clinical characteristics were present in our cases.…”

Section: Discussionsupporting

confidence: 64%

Gastrosplenic Fistula Due to Splenic Lymphoma: Two Case Reports and Literature Review

Letaief¹,

Nefzi²,

Khrouf³

et al. 2021

Preprint

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PurposeGastrosplenic fistula (GSF) is a rare and potentially fatal complication of various diseases, of which lymphoma is the most common cause. We aim through our work to relate two cases of GSF and to review literature. Methods We reviewed two cases treated in our department of GSF and made a research in Pubmed using the keywords “Gastrosplenic fistula” and “Splenic lymphoma”.Results GSF is a rare condition that can occur spontaneously or after initiation of chemotherapy. It arises from the rapid growth of tumour and invasion of surrounding organs. Diagnosis may be difficult to make and confused with splenic abscess. Treatment modalities include surgical resection, chemotherapy or a combination of both. Here we report two cases of GSF due to diffuse large B cell lymphoma patients. The first case is of a 54-year-old woman with a spontaneous fistula in the stomach. The second one is of a 48 year-old- male patient presenting a fistula after chemotherapy. Both patients died after surgery. ConclusionGSF is a rare but dangerous condition in which surgery is currently the preferred treatment.

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Section: Discussionsupporting

confidence: 64%

Gastrosplenic Fistula Due to Splenic Lymphoma: Two Case Reports and Literature Review

Letaief¹,

Nefzi²,

Khrouf³

et al. 2021

Preprint

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show abstract

“…It is theorised by some that uncomplicated GSFs (non-perforated, no GI bleeding) could be safely treated solely with chemotherapy 6. Chemotherapy alone has been tried in a total of four patients as a definitive management strategy 6–9. Two out of four patients were either lost to follow-up or died after 2 months of treatment.…”

Section: Discussionmentioning

confidence: 99%

Successful multidisciplinary management of an asymptomatic gastrosplenic fistula in a diffuse large B cell lymphoma patient

2022

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Gastrosplenic fistula is a rare and potentially fatal clinical entity unknown to most healthcare providers. Its diagnosis and management are challenging; and addressing it too late can have devastating consequences for patients. To increase awareness about this pathology, we hereby present a case of asymptomatic gastrosplenic fistula arising from a diffuse large B cell lymphoma in a 60-year-old Caucasian man with no significant medical history. The patient was successfully treated with open en-bloc splenectomy and partial gastrectomy. The patient was discharged from the hospital 3 days after the surgery. At 1-month postoperatively, the patient was asymptomatic and presented no complication of the surgery. He went on to finish six cycles of chemotherapy (R-EPOCH, rituximab, etoposide phosphate, prednisone, vincristine sulfate, cyclophosphamide, doxorubicin hydrochloride) and achieved complete metabolic response. At 2 years after the surgery, the patient remains asymptomatic and presents no sign of disease recurrence.

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“…As in our case, spontaneous GSF without chemotherapy may occur very rarely. Most of the reported cases of spontaneous GSF are primary splenic lymphoma without lymphadenopathy (Bird, Amjadi, & Behrns, 2002; Choi et al, 2002; Khan, Vessal, McKimm, & D' Souza, 2010; Maillo & Bau, 2009). Our case was evaluated as DLBCL with splenic involvement because of the widespread multiple hypermetabolic lymph nodes noted on the PET-CT.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Gastrosplenic Fistula: An Unusual Presentation of Diffuse Large B Cell Lymphoma

Bülbül

İrak

Berk

et al. 2022

Gastroenterology Nursing

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Spontaneous gastrosplenic fistula secondary to primary splenic lymphoma

Cited by 20 publications

References 16 publications

Gastrosplenic Fistula Due to Splenic Lymphoma: Two Case Reports and Literature Review

Gastrosplenic Fistula Due to Splenic Lymphoma: Two Case Reports and Literature Review

Successful multidisciplinary management of an asymptomatic gastrosplenic fistula in a diffuse large B cell lymphoma patient

Spontaneous Gastrosplenic Fistula: An Unusual Presentation of Diffuse Large B Cell Lymphoma

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