Spontaneous Glomerular and Tubulointerstitial Lesions in Common Marmosets (<i>Callithrix jacchus</i>)

Isobe, Kimiaki; Adachi, Kenji; Hayashi, Shim-mo; Ito, Toshio; Miyoshi, A.; Kato, Akiko; Suzuki, Michitaka

doi:10.1177/0300985811427151

Cited by 26 publications

(24 citation statements)

References 15 publications

(24 reference statements)

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“…Recently, a correlation between expansion of mesangial matrix and age and between glomerular and tubulointerstitial lesions was reported by Isobe et al (2012). They revealed that the increase in mesangial matrix progressed with age, and the tubulointerstitial lesions were correlated with the glomerular lesions.…”

Section: Introductionmentioning

confidence: 96%

Morphological Study of Progressive Glomerulonephropathy in Common Marmosets (Callithrix jacchus)

et al. 2013

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Spontaneous progressive glomerulonephropathy often occurs in common marmosets. However, there are few detailed reports concerning the agerelated progressive process of glomerular changes. We discuss the glomerular changes in the early stage and the progressive changes in the advanced stage of nephropathy. We investigated the kidneys of common marmosets (2-11 years old; 9 males and 12 females) using hematoxylin and eosin, periodic acid-Schiff, periodic acid-methenamine-silver, and Masson's trichrome (MT) stains and a transmission electron microscope. There was no remarkable change in urine cytology, hematology, or blood chemistry. In the early stage of nephropathy, effacement of podocyte foot processes was observed ultrastructurally even though there were no marked glomerular lesions in the light microscopy. Subsequently, mesangial proliferation occurred from the hilar to peripheral side along the tuft. In the middle stage, red deposits were visible at the glomerular basement membrane (GBM) and the mesangial region directly under the GBM (paramesangial area) with the MT stain. Electron dense deposits were seen at the same area. In the advanced stage, the irregularity became prominent with or without dense deposits. It is necessary to investigate in detail whether the change of podocyte in the early stage was immuno-mediated or due to podocyte failure.

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Section: Introductionmentioning

confidence: 96%

Morphological Study of Progressive Glomerulonephropathy in Common Marmosets (Callithrix jacchus)

et al. 2013

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“…Acute experimental liver damage in cirrhotic rats also induced renal dysfunction with increases in serum creatinine, bilirubin, and BUN levels [85]. Collectively, these data suggest that GBV-B, like many other viral infections, could induce kidney dysfunction, but it is also important to point out that marmosets have a propensity to develop spontaneous benign glomerulonephropathy [86–88]. Thus, further studies will be necessary to determine if kidney disease is a true complication of GBV-B infection.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Dysregulation in Hepacivirus Infection of Common Marmosets (Callithrix jacchus)

et al. 2017

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Chronic hepatitis C has been associated with metabolic syndrome that includes insulin resistance, hepatic steatosis and obesity. These metabolic aberrations are risk factors for disease severity and treatment outcome in infected patients. Experimental infection of marmosets with GBV-B serves as a tangible, small animal model for human HCV infection, and while virology and pathology are well described, a full investigation of clinical disease and the metabolic milieu is lacking. In this study six marmosets were infected intravenously with GBV-B and changes in hematologic, serum biochemical and plasma metabolic measures were investigated over the duration of infection. Infected animals exhibited signs of lymphocytopenia, but platelet and RBC counts were generally stable or even increased. Although most animals showed a transient decline in blood glucose, infection resulted in several fold increases in plasma insulin, glucagon and glucagon-like peptide 1 (GLP-1). All infected animals experienced transient weight loss within the first 28 days of infection, but also became hypertriglyceridemic and had up to 10-fold increases in adipocytokines such as resistin and plasminogen activator inhibitor 1 (PAI-1). In liver, moderate to severe cytoplasmic changes associated with steatotic changes was observed microscopically at 168 days post infection. Collectively, these results suggest that GBV-B infection is accompanied by hematologic, biochemical and metabolic abnormalities that could lead to obesity, diabetes, thrombosis and atherosclerosis, even after virus has been cleared. Our findings mirror those found in HCV patients, suggesting that metabolic syndrome could be conserved among hepaciviruses, and both mechanistic and interventional studies for treating HCV-induced metabolic complications could be evaluated in this animal model.

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“…Spontaneous progressive nephropathy dominated by glomerular lesions in common marmosets has been reported 20 , 21 . The historical renal lesion in common marmosets is characterized by glomerular lesions with an increase in mesangial matrix, which progresses with aging, and secondary tubulointerstitial lesions, including tubular hyperplasia 20 .…”

Section: Discussionmentioning

confidence: 99%

“…The historical renal lesion in common marmosets is characterized by glomerular lesions with an increase in mesangial matrix, which progresses with aging, and secondary tubulointerstitial lesions, including tubular hyperplasia 20 . In our study, two non-treated control animals showed remarkable tubulointerstitial nephritis without any glomerular changes and interstitial fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…The marmoset has been used successfully by a number of pharmaceutical and biotechnology companies to support clinical trials and for product registration with the United States (US) Food and Drug Administration (FDA) and the European Medicines Agency (EMA) 14 , 15 . In addition, the common marmoset shows a higher incidence of renal lesions including glomerulo- and tubulointerstitial nephritis or progressive nephropathy 16 , 17 , 18 , 19 , 20 , 21 compared with that in the cynomolgus monkey 22 , 23 .…”

Section: Introductionmentioning

confidence: 99%

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Five-sixth Nephrectomy in Female Common Marmosets (<i>Callithrix jacchus</i>) as a Chronic Renal Failure Model

et al. 2014

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To assess the relevance and availability of subtotal nephrectomized common marmoset monkeys as a chronic renal failure (CRF) model, we observed for 26 weeks the pathophysiological condition of female marmosets subjected to five-sixth surgical nephrectomy (5/6Nx) by a two-step surgical method. The 5/6Nx marmosets showed a significant increase in serum levels of urea nitrogen, creatinine and cystatin-C immediately after 5/6Nx surgery. These renal disorder parameters subsequently tended to decrease with the passage of time but remained higher than the control levels by the end of the study. Hyperplastic parathyroid glands, a high turnover state of osteodystrophy in the femoral bone with higher serum ALP activity and anemia with hypocellularity of bone marrow were evident. The 5/6Nx marmosets showed a stable CRF condition for a long time and some characteristic disorders similar to those observed in CRF patients. These diagnostic aspects might be a species-specific anatomical and physiological signature, reflecting the nutritional condition. The CRF model using 5/6Nx marmosets might become a useful method of evaluating the unique mechanism of CRF development.

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Spontaneous Glomerular and Tubulointerstitial Lesions in Common Marmosets (Callithrix jacchus)

Cited by 26 publications

References 15 publications

Morphological Study of Progressive Glomerulonephropathy in Common Marmosets (Callithrix jacchus)

Morphological Study of Progressive Glomerulonephropathy in Common Marmosets (Callithrix jacchus)

Metabolic Dysregulation in Hepacivirus Infection of Common Marmosets (Callithrix jacchus)

Five-sixth Nephrectomy in Female Common Marmosets (<i>Callithrix jacchus</i>) as a Chronic Renal Failure Model

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