Spontaneous healing of the tympanic membrane after traumatic perforation in rats

Araújo, Marcos Miranda de; Murashima, Adriana de Andrade Batista; Alves, Vâni Maria; Jamur, Maria Célia; Hyppolito, Miguel Ângelo

doi:10.1016/j.bjorl.2014.05.014

Cited by 25 publications

(42 citation statements)

References 19 publications

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“…Animal studies have demonstrated that perforations heal by means of epithelial migration which starts from the outer epithelial layer, with later healing of the lamina propria and the mucosal layer. 23 The epithelial generation center is located near the annulus and the handle of the malleus. 24 Otologists opined that patients with all forms of traumatic conductive hearing loss can be initially managed conservatively, and that even suspected ossicular chain disruptions have a high rate of spontaneous reparation.…”

Section: Discussionmentioning

confidence: 99%

Traumatic tympanic membrane perforations: characteristics and factors affecting outcome

Sogebi¹,

Oyewole²,

Mabifah³

2018

Ghana Medical Journal

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Section: Discussionmentioning

confidence: 99%

Traumatic tympanic membrane perforations: characteristics and factors affecting outcome

Sogebi¹,

Oyewole²,

Mabifah³

2018

Ghana Medical Journal

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“…6,11 KZ akut perforasyonundan sonra iyileşme süresi 7-10. günde başlamakta ve 14. günde tamamlanmaktadır. 1 Literatürde yapılmış çalışmalarda, bu sürelerde topikal farklı maddelerde bir veya iki gün iyileşme süresi erken bulunmuş olsa da çalışmamızda perforasyon sonrasında sponjeller konularak damlalar damlatıldığından, ratların anestezi ile tekrar tekrar sponjellerin çıkarılması zorluğu ve olu-şabilecek travma nedeni ile kapanma süresi değerlendirilmemiştir. 14,15 İyileşme süresinde normale yakın bir dokunun oluşumu amaçlanmış ve sonuçlar doğrultusunda dekspantenol grubunda kontrol gruplarına göre perforasyonların kapanması ve sklerotik plakların oluşmaması maddenin etkin olabileceğini göstermektedir.…”

Section: Discussionunclassified

Effect of Topical Dexpanthenol on Myringosclerosis of Traumatic Tympanic Membrane Perforation

Öz¹,

Helvacıoğlu²,

Koca³

et al. 2018

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ulak zarı (KZ), insanlarda olduğu gibi ratlarda da, lateralden mediyale doğru üç tabakadan oluşmaktadır. Bunlar; keratinize strafiye skuamöz epitelden oluşan kutanöz tabaka, lateralde radiyal, mediyalde sirküler seyreden liflerin yer aldığı fibröz tabaka ve orta kulak mukozasının devamı olan basit kolumnar epitel ile döşeli mukozal tabakadır. 1,2 KZ perforasyonu, insanlarda sık görülen klinik bir problemdir. Travma, akut otitis media ve miringotomi sonrası meydana gelen akut KZ perforasyonlarının büyük bir kısmı kendiliğinden kapanır iken, kronik perforasyonlar sıklıkla

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“…Surgical intervention, in this case myringotomy and TT placement, results in both short-and long-term effects that influence several changes in an infected MEC. With myringotomy, a renewed immune and healing response is stimulated 56 along with aspiration of the MEC and insertion of a TT. These interventions aid in clearing middle-ear fluid and provide a means of aerating the MEC.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention

Monroy

Pande²,

Nolan

et al. 2017

J. Biomed. Opt.

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In an institutional review board-approved study, 25 pediatric subjects diagnosed with chronic or recurrent otitis media were observed over a period of six months with optical coherence tomography (OCT). Subjects were followed throughout their treatment at the initial patient evaluation and preoperative consultation, surgery (intraoperative imaging), and postoperative follow-up, followed by an additional six months of records-based observation. At each time point, the tympanic membrane (at the light reflex region) and directly adjacent middle-ear cavity were observed in vivo with a handheld OCT probe and portable system. Imaging results were compared with clinical outcomes to correlate the clearance of symptoms in relation to changes in the image-based features of infection. OCT images of most all participants showed the presence of additional infection-related biofilm structures during their initial consultation visit and similarly for subjects imaged intraoperatively before myringotomy. Subjects with successful treatment (no recurrence of infectious symptoms) had no additional structures visible in OCT images during the postoperative visit. OCT image findings suggest surgical intervention consisting of myringotomy and tympanostomy tube placement provides a means to clear the middle ear of infection-related components, including middle-ear fluid and biofilms. Furthermore, OCT was demonstrated as a rapid diagnostic tool to prospectively monitor patients in both outpatient and surgical settings.

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Spontaneous healing of the tympanic membrane after traumatic perforation in rats

Abstract: The spontaneous healing process of the tympanic membrane starts from the outer epithelial layer, with later healing of the lamina propria and the mucosal layer.

Cited by 25 publications

References 19 publications

Traumatic tympanic membrane perforations: characteristics and factors affecting outcome

Traumatic tympanic membrane perforations: characteristics and factors affecting outcome

Effect of Topical Dexpanthenol on Myringosclerosis of Traumatic Tympanic Membrane Perforation

Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention

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