2023
DOI: 10.1101/2023.06.07.543414
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Spontaneous human CD8 T cell and EAE-inducible human CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1*15-positive multiple sclerosis PBMC humanized mice

Irini Papazian,
Maria Kourouvani,
Anastasia Dagkonaki
et al.

Abstract: Autoimmune diseases of the central nervous system such as multiple sclerosis (MS) are only partially represented in current experimental models and the development of humanized immune mice is crucial for better understanding of immunopathogenesis and testing of novel therapeutics. We describe a humanized mouse model with several key MS features. Severely immunodeficient B2m-NOG mice were transplanted with peripheral blood mononuclear cells (PBMC) from MS and healthy (HI) donors and showed rapid engraftment by … Show more

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