Spontaneous hyphaema in childhood

Murdoch, IanA.; Anjos, Rui; Parsons, Jonathan; Calver, D.

doi:10.1007/bf01958762

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…6 Spontaneous hyphema may be seen in hematological diseases with impaired blood parameters and a tendency to bleed, such as sickle cell anemia, leukemia, haemophilia and immune thrombocytopenia in childhood. 7,8 Furthermore, the use of anti-coagulants 9 or nonsteroidal anti-inflammatory drugs (NSAID) (anti-platelet activity) 3,10 , may contribute to hyphema formation. In addition, infiltrating iris anomalies such as histiocytosis, retinoblastoma or juvenile xanthogranulomatosis involving the iris and ciliary body may cause hyphema.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous hyphema in juvenile idiopathic arthritis uveitis

Aygün¹,

Kadayıfçılar²,

Özen³

2023

Turk J Pediatr

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Background. Juvenile idiopathic arthritis (JIA) is a rheumatic disease that may be associated with ocular involvement in childhood. Classical findings of JIA uveitis are cells and flare; hyphema, bleeding in the anterior chamber of the eye, is a rare finding.Case. An 8-year-old girl presented with 3+ cells and a flare in the anterior chamber. Topical corticosteroids were started. A follow-up examination 2 days later revealed hyphema in the affected eye. There was no history of trauma or drug use, and the laboratory test results did not suggest any hematological disease. Systemic evaluation resulted in the diagnosis of JIA by the rheumatology department. The findings regressed with systemic and topical treatment. Conclusions.The most common cause of hyphema in childhood is trauma, but it can rarely be seen with anterior uveitis. This case highlights the importance of recognizing JIA-related uveitis in the differential diagnosis of hyphema in childhood.

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Section: Discussionmentioning

confidence: 99%

“…In addition, infiltrating iris anomalies such as histiocytosis, retinoblastoma or juvenile xanthogranulomatosis involving the iris and ciliary body may cause hyphema. 7 Hyphema due to non-traumatic reasons such as uveitis is a rare condition in children. Duke-Elder and Perkins 11 described petechial…”

Section: Discussionmentioning

confidence: 99%

Spontaneous hyphema in juvenile idiopathic arthritis uveitis

Aygün¹,

Kadayıfçılar²,

Özen³

2023

Turk J Pediatr

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“…Spontaneous hyphaema has been associated with sickle cell disease,7 although the exact pathogenesis is unknown. It is not implausible that vitreous haemorrhage could spill over into the anterior chamber causing hyphaema.…”

Section: Discussionmentioning

confidence: 99%

Intravitreal bevacizumab (Avastin) associated with secondary hyphaema in a case of proliferative sickle cell retinopathy

Babalola¹

2010

Case Reports

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Intravitreal bevacizumab (Avastin) has been used off label for various conditions, including proliferative sickle cell retinopathy (PSR). Some authors have reported a more rapid resolution of the vitreous haemorrhage in Goldberg stage 4 PSR. Following injection of 1.25 mg of bevacizumab in each eye in a case of PSR (right eye with stage 3 sea fan neovascularisation and left eye with organising vitreous haemorrhage), we recently found a surprising association with significant secondary hyphaema on the fifth day post injection in the eye with vitreous haemorrhage. After 4 weeks, there was a dramatic fibrotic resolution of the stage 3 sea fan in the other eye. Systemic bevacizumab as used in the management of colorectal cancer has been associated with bleeding diathesis in some cases, as well as with deep venous thrombosis. The rheological profile of bevacizumab is not clear-cut at the moment and the drug should therefore be used with caution in cases of stage 4 PSR.

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