Spontaneous improvement in a pediatric patient with peripheral T‐cell lymphoma

Abstract

Peripheral T-cell lymphoma (PTCL) is rare in children, and it has a poor prognosis compared with other types of lymphoma. We report the case of a 7-year-old boy with spontaneous improvement of PTCL complicated by hemophagocytic syndrome as the initial symptom. He complained of pain and swelling of the right neck and presented with high fever. Pancytopenia, liver dysfunction, elevated ferritin and soluble interleukin 2 receptor were noted on laboratory tests. Peripheral blood plasma and white blood cells were positive for Epstein-Barr virus (EBV) genome but, after several days, the fever abated and laboratory data improved. On histopathology of lymph node biopsy, he was diagnosed as having PTCL not otherwise specified (PTCL-NOS) with EBV infection. He received no chemotherapy and was disease free at the last follow up, 6 years 8 months after onset. This is probably the first case of spontaneous improvement in PTCL-NOS. Careful treatment planning is therefore necessary in PTCL-NOS, given the possibility of spontaneous improvement of symptoms.

Durable Response in Relapsed Adolescent Peripheral T-cell Lymphoma: A Case Report and Review of the Literature

“…A few larger cohort studies have shown numerous regimens utilized, including anthracycline-based, T-cell NHL-based, and B-cell NHL-based chemotherapy regimens, with or without surgery, radiation, or HSCT (Table 1). 2,[7][8][9][10][11][12] The SEER reported among 103 pediatric patients, 5-year overall survival (OS) of 59% with 10-year OS of 56%, which is better than their adult counterparts, which ranged from 11% to 56% based on their International Prognostic Index. 3,5 The role of HSCT remains controversial in this disease.…”

Epstein-Barr virus positive peripheral T cell lymphoma with novel variants in STAT5B of a pediatric patient: a case report

“…EBV + PTCL, as a variant of PTCL-NOS, is a rare malignancy which is more frequent in the late adulthood with high clinical stage and aggressive clinical course [ 2 ]. however, for the patients of childhood, it was extremely rare with limited cases have been reported (Additional file 4 : Table S1) [ 4 , 5 , 7 ]. For these cases, lymph node involvement was the significant feature with the common site of cervical region.…”