“…Meanwhile, perforation of the colon is a rare condition [1], [2], and [3]. In premature neonates, colon perforation is most commonly caused by necrotizing enterocolitis (NEC), generally associated with Hirschsprung disease, meconium plug syndrome, small left colon syndrome, idiopathic perforation, anorectal malformation, and cystic fibrosis [1], [4]. In the term neonates, Hirschsprung disease is the most common cause, followed by NEC and spontaneous idiopathic perforation [5], [6].…”