Spontaneous Intracerebral Haemorrhage: An Analysis of Factors Affecting Prognosis

Dixon, Alison; Holness, Renn O.; Howes, William J.; Garner, J.B.

doi:10.1017/s0317167100047144

Cited by 43 publications

(27 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In particular, level of consciousness on admission has been reported to be one of the most important independent predictors of 30-day 36) , 1-year 31) , and all in hospital mortalities 4) . Other studies 12,40) have used GCS to assess level of consciousness. In the present study, we found a similar relation between GCS and level of consciousness graded simply as conscious or unconscious, as described in the RLS 11,37) .…”

Section: Discussionmentioning

confidence: 99%

Predictors of 30-Day Mortality and 90-Day Functional Recovery after Primary Intracerebral Hemorrhage : Hospital Based Multivariate Analysis in 585 Patients

Kim

2009

J Korean Neurosurg Soc

View full text Add to dashboard Cite

Objective : The purpose of this study was to identify independent predictors of mortality and functional recovery in patients with primary intracerebral hemorrhage (PICH) and to improve functional outcome in these patients. Methods : Data were collected retrospectively on 585 patients with supratentorial PICH admitted to the Stroke Unit at our hospital between 1st January 2004 and the 31st July 2008. Using multivariate logistic regression analysis, the associations between all selected variables and 30-day mortality and 90-day functional recoveries after PICH was evaluated. Results : Ninety-day functional recovery was achieved in 29.1% of the 585 patients and 30-day mortality in 15.9%. Age (OR=7.384, p=0.000), limb weakness (OR=6.927, p=0.000), and hematoma volume (OR=5.293, p=0.000) were found to be powerful predictors of 90-day functional recovery. Furthermore, initial consciousness (OR=3.013, p=0.014) hematoma location (lobar, OR=2.653, p=0.003), ventricular extension of blood (OR=2.077, p=0.013), leukocytosis (OR=2.048, p=0.008), alcohol intake (drinker, OR=1.927, p=0.023), and increased serum aminotransferase (OR=1.892, p=0.035) were found to be independent predictors of 90-day functional recovery after PICH. On the other hand, a pupillary abnormality (OR=4.532, p=0.000) and initial unconsciousness (OR=3.362, p=0.000) were found to be independent predictors of 30-day mortality after PICH. Conclusion :The predictors of mortality and functional recovery after PICH identified during this analysis may assist during clinical decisionmaking, when advising patients or family members about the prognosis of PICH and when planning intervention trials.

show abstract

Section: Discussionmentioning

confidence: 99%

Predictors of 30-Day Mortality and 90-Day Functional Recovery after Primary Intracerebral Hemorrhage : Hospital Based Multivariate Analysis in 585 Patients

Kim

2009

J Korean Neurosurg Soc

View full text Add to dashboard Cite

show abstract

“…Spontaneous ICH accounts for 4% to 15% of cases of acute stroke but is the most fatal form of this disease. [1][2][3][4][5][6] Warfarin use increases both the risk of developing ICH [7][8][9][10] and its mortality. 1,11 The effect of warfarin on ICH severity appears to be related to an increased risk of continued in-hospital bleeding.…”

mentioning

confidence: 99%

Timing of Fresh Frozen Plasma Administration and Rapid Correction of Coagulopathy in Warfarin-Related Intracerebral Hemorrhage

Goldstein

Thomas

Frontiero

et al. 2006

Stroke

201

121

View full text Add to dashboard Cite

Background and Purpose-Anticoagulation-related intracerebral hemorrhage (ICH) is often fatal, and rapid reversal of anticoagulation is the most appealing strategy currently available for treatment. We sought to determine whether particular emergency department (ED) interventions are effective in reversing coagulopathy and improving outcome. Methods-Consecutive patients with warfarin-related ICH presenting to an urban tertiary care hospital from 1998 to 2004were prospectively captured in a database. ED records were retrospectively reviewed for dose and timing of fresh-frozen plasma (FFP) and vitamin K, as well as serial coagulation measures.

show abstract

“…25,26 The prognosis for patients with RPCH was worse than for those with nonrecurrent bleeding. Only 27% of patients had good functional recovery compared with 37% to 55% of patients with a first cerebral hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Primary Cerebral Hemorrhage

González‐Duarte

Cantú

Ruiz-Sandoval

et al. 1998

Stroke

View full text Add to dashboard Cite

Background and Purpose-The frequency of recurrent primary cerebral hemorrhage (RPCH), mainly in cases related to hypertension, has been considered low. This study investigated the frequency, mechanisms, and prognosis of RPCH. Methods-We evaluated 359 patients with neuroimaging evidence of cerebral hemorrhage and selected 22 with RPCH. Results-Five patients (23%) were older than 70 years at the first cerebral hemorrhage. Mean ages at the first and second hemorrhages were 60 and 63 years, respectively. Risk factors included hypertension (86%), diabetes (27%), and tobacco and alcohol use (each 14%). Hypocholesterolemia was demonstrated in 35% of the patients. The most common pattern of recurrent bleeding was ganglionic-ganglionic, mainly related to hypertension. Overall mortality was 32%. Forty-one percent and 27% of patients, respectively, had incapacitating and nonincapacitating sequelae; 2 of the latter had RPCH with a lobar location. Ganglionic-ganglionic hemorrhage was associated with a poor prognosis; otherwise, this pattern was uncommon in patients with nonincapacitating sequelae. Analysis of the control of risk factors, primarily hypertension after the first cerebral hemorrhage, disclosed that 56% of patients did not gain subsequent control. Conclusions-Rebleeding after a first primary intracerebral hemorrhage is not uncommon. The main topographic pattern of bleeding, ganglionic-ganglionic, is likely the result of hypertension; the less common lobar-lobar pattern probably results from amyloid angiopathy. (Stroke. 1998;29:1802-1805.)

show abstract

Spontaneous Intracerebral Haemorrhage: An Analysis of Factors Affecting Prognosis

Cited by 43 publications

References 22 publications

Predictors of 30-Day Mortality and 90-Day Functional Recovery after Primary Intracerebral Hemorrhage : Hospital Based Multivariate Analysis in 585 Patients

Predictors of 30-Day Mortality and 90-Day Functional Recovery after Primary Intracerebral Hemorrhage : Hospital Based Multivariate Analysis in 585 Patients

Timing of Fresh Frozen Plasma Administration and Rapid Correction of Coagulopathy in Warfarin-Related Intracerebral Hemorrhage

Recurrent Primary Cerebral Hemorrhage

Contact Info

Product

Resources

About