Spontaneous intralesional haemorrhage in dysembryoplastic neuroepithelial tumours: a series of five cases

Abstract

Five patients with dysembryoplastic neuroepithelial tumour (DNT) showing extensive secondary haemorrhage, a finding not previously associated with these neoplasms, are described. The clinical presentations, neuroimaging findings, and histopathological features of these patients are reviewed. One patient, a previously asymptomatic 12 year old girl, presented with an acute intracerebral haemorrhage into a DNT. A further four young adults with histories of intractable partial and generalised seizures dating from childhood showed significant chronic haemorrhages within DNT, the MRI appearances in one patient giving a false impression of a cavernoma. Histopathology disclosed vascular abnormalities within these tumours which, together with other factors discussed, may have predisposed these tumours to haemorrhage. (J Neurol Neurosurg Psychiatry 1999;67:97-101)

Multifocal dysembryoplastic neuroepithelial tumours associated with refractory epilepsy

“…Yang, et al with DNETs. Progressive enlargement of DNETs from spontaneous intralesional haemorrhage and formation of cystic cavities has also been observed elsewhere (Thom et al, 1999). Our patient's seizures were eliminated by the surgery, however, reducing his all-cause mortality risk to that of the general population.…”

Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowth

“…7 Their favorable prognosis is also due to the fact that most lesions remain stable, yet rare cases with slow progression or hemorrhage due to hamartomatous vessels have been reported. 8,9 Outcome after surgical resection has also been considered favorable, as the majority of children remain seizure-free. 10 In contrast, a long history of epilepsy, older age at time of surgery and adult cases are associated with worse prognosis.…”

“…In about one‐third of cases contrast enhancement in MRI is observed 7 . Their favorable prognosis is also due to the fact that most lesions remain stable, yet rare cases with slow progression or hemorrhage due to hamartomatous vessels have been reported 8,9 . Outcome after surgical resection has also been considered favorable, as the majority of children remain seizure‐free 10 .…”

Unusual Presentation of a Dysembryoplastic Neuroepithelial Tumor Mimicking a Pontomesencephalic Cavernous Hemangioma

“…Other sites or origin are very rare [3][4][5][6][7]. Although most patients present with a history of long-standing seizures that are refractory to medication, rare presentations with clinically silent, chronic hemorrhagic depositions simulating a cavernous hemoangioma on magnetic resonance imaging (MRI) have been reported [8]. We report a unique case of DNET at the pontomesencephalic junction with acute spontaneous hemorrhage, which complicated the clinical presentation and blurred the differential diagnoses.…”