Spontaneous lesions of nasal cavity in aging F344 rats and BDF1 mice

Nagano, Kasuke; Katagiri, Taku; Aiso, Shigetoshi; Senoh, Hideki; Sakura, Yumi; Takeuchi, Tetsuya

doi:10.1016/s0940-2993(97)80077-2

Cited by 39 publications

(29 citation statements)

References 4 publications

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“…The respiratory metaplasia of the olfactory epithelium is considered to represent replacement of the affected epithelium with the respiratory-like epithelium in which those epithelial cells showed characteristics of the ciliated and non-ciliated cells of adjacent normal respiratory epithelium. The present microscopic observations of the p-DCB-induced nasal lesions led us to conclude on the basis of the previously reported findings on the nasal cavity of aged animals [29,42] and chemically exposed animals [10,26] that long-term inhalation exposure to p-DCB accelerates the age-related changes in degenerative responses of the nasal cavity to the inhaled toxicant, including the loss of olfactory cells.…”

Section: Discussionsupporting

confidence: 82%

“…Those nasal lesions were reported to occur in aged mice and rats of both sexes [29,42]. In the previous 13-week inhalation study [1], however, no nasal lesion was detected in any of the 19-week-old, p-DCBexposed or control mice or rats of either sex (data not shown there because those nasal lesions were absent).…”

Section: Discussionmentioning

confidence: 75%

“…The pretreatment of the nasal cavity and the method for trimming of 3 frontal sections ( Fig. 1) were described in our previous paper [29]. Tissue sections of 5 µm in thickness were prepared, and stained with hematoxy-…”

Section: Methodsmentioning

confidence: 99%

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Carcinogenicity and Chronic Toxicity in Mice and Rats Exposed by Inhalation to para-Dichlorobenzene for Two Years

et al. 2005

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ABSTRACT. Carcinogenicity and chronic toxicity of para-dichlorobenzene (p-DCB) were examined by exposing 50 BDF 1 mice and 50 F344 rats of both sexes by inhalation to p-DCB vapor at a target concentration of 0 (control), 20, 75 or 300 ppm for 6 hr/day, 5 days/ week and 2 years. Incidences of hepatocellular carcinomas, hepatoblastomas and hepatic histiocytic sarcomas in the 300 ppm-exposed male mice, and hepatocellular adenomas and carcinomas and hepatoblastomas in the 300 ppm-exposed female mice were increased. An increase in the incidences of most of those liver tumors was dose-related. No increase in tumor incidence was found in any p-DCBexposed rat of either sex. Centrilobular hypertrophy of hepatocytes and papillary mineralization and pelvic urothelial hyperplasia of the kidney were noted in the 300 ppm-exposed male rats. Treatment-and age-related increases in incidences of the eosinophilic globules of the respiratory and olfactory epithelia in female rats and incidences of the respiratory metaplasia of the nasal gland epithelium in mice and rats and the olfactory epithelium in mice were noted. The nasal lesion was the most sensitive endpoint of chronic inhalation toxicity. Induction of the mouse hepatocarcinogenicity and lack of the rat nephrocarcinogenicity found in the present study were compared with the mouse liver tumors and the rat renal tumors reported by the NTP gavage study, and discussed in light of the estimated p-DCB uptake into the body through the inhalation and the oral administration. KEY WORDS: liver tumor, nasal lesion, para-Dichlorobenzene.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 75%

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Carcinogenicity and Chronic Toxicity in Mice and Rats Exposed by Inhalation to para-Dichlorobenzene for Two Years

et al. 2005

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“…It is known that these eosinophilic changes occur spontaneously in aged rats and mice, although the etiology of these changes is uncertain (Nagano et al, 1997). In rasH2 mice, skeletal myopathy, which is characterized by variation in muscle fiber size, centrally placed nuclei, regenerating fibers, and interstitial fibrosis, has been reported to be a spontaneous histopathological lesion with no difference with respect to gender (Tsuchiya et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

A 26-Week Carcinogenicity Study of 2-Amino-3-Methylimidazo[4,5-f]Quinoline in rasH2 Mice

et al. 2006

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To evaluate the carcinogenic susceptibility of rasH2 mice to 2-amino-3-methylimidazo[4,5-f ]quinoline (IQ), 7-week-old rasH2 mice and their wild-type littermates (non-Tg mice) of both the sexes were fed a diet containing 0 or 300 ppm IQ for 26 weeks. Microscopical examinations revealed that the proliferative lesions of the forestomach, including squamous cell hyperplasias, papillomas, and carcinomas, were frequently encountered in male and female rasH2 mice fed with IQ. In non-Tg mice, no significant differences in the incidence of forestomach lesions were observed between the 0 ppm and 300 ppm groups. Histopathological changes such as periportal hepatocellular hypertrophy and oval cell proliferation in the liver were more apparent in female rasH2 and non-Tg mice than in males, and the incidence of hepatocellular altered foci significantly increased in female rasH2 mice in the 300 ppm group as compared to that in the 0 ppm group. These results suggest that the carcinogenic potential of IQ can be detected in rasH2 mice by a 26-week, short-term carcinogenicity test.

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“…The organs and tissues were fixed in 10% neutral buffered formalin. The nasal cavity was decalcified in a formic acid formalin solution prior to trimming, and was transversely trimmed at three levels according to the procedure described previously (Nagano et al, 1997). The organs and tissues were prepared for staining with hematoxylin and eosin (H&E).…”

Section: Pathological Examinationsmentioning

confidence: 99%

Carcinogenicity of quinoline by drinking-water administration in rats and mice

Matsumoto¹,

Kano²,

Suzuki³

et al. 2018

J. Toxicol. Sci.

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-The carcinogenicity of quinoline was examined by administrating quinoline in the drinking water to groups of 50 F344/DuCrj rats and 50 Crj: BDF1 mice of each sex. In rats, the doses of quinoline were 0, 200, 400, and 800 ppm for males and 0, 150, 300, and 600 ppm for females. In male rats, administration of quinoline was terminated at week 96 due to high mortality caused by tumors. There were significant increases of hepatocellular adenomas, hepatocellular carcinomas, hepatocellular adenomas and/or carcinomas (combined), and liver hemangiomas, hemangiosarcomas, hemangiomas and/ or hemangiosarcomas (combined) in both male and female rats, and nasal esthesioneuroepitheliomas and sarcoma NOS (not otherwise specified) in males. In mice, doses of quinoline were 0, 150, 300 and 600 ppm for both males and females. Administration of quinoline was terminated at week 65 in males and at week 50 in females due to high mortality caused by tumors. There were marked increases of hemangiomas, hemangiosarcomas, and hemangiomas and/or hemangiosarcomas (combined) in the retroperitoneum, mesenterium, and liver in males, and in the retroperitoneum, mesenterium, peritoneum, and subcutis in females. Additionally, histiocytic sarcomas were statistically increased in the livers of female mice. Thus the present studies provided clear evidence of carcinogenic activity of quinoline administered in the drinking water in both rats and mice.

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Spontaneous lesions of nasal cavity in aging F344 rats and BDF1 mice

Cited by 39 publications

References 4 publications

Carcinogenicity and Chronic Toxicity in Mice and Rats Exposed by Inhalation to para-Dichlorobenzene for Two Years

Carcinogenicity and Chronic Toxicity in Mice and Rats Exposed by Inhalation to para-Dichlorobenzene for Two Years

A 26-Week Carcinogenicity Study of 2-Amino-3-Methylimidazo[4,5-f]Quinoline in rasH2 Mice

Carcinogenicity of quinoline by drinking-water administration in rats and mice

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