Spontaneous magnetoencephalographic activity in patients with obsessive-compulsive disorder

Maihöfner, Christian; Sperling, Wolfgang; Kaltenhäuser, Martin; Bleich, Stefan; Zwaan, Martina de; Wiltfang, Jens; Thürauf, Norbert; Elstner, Samuel; Reulbach, Udo; Lewczuk, Piotr; Kornhuber, Johannes; Ropohl, Axel

doi:10.1016/j.brainres.2006.10.048

Cited by 19 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The OCD group exhibited spontaneous over-activity at all frequency ranges (Figures 1C,F) in agreement with a previous MEG study (Maihofner et al, 2007). As summarized in a recent review, abnormal brain activity is not unusual in OCD, and increased theta range activity has been reported in several studies (Clark et al, 2009).…”

Section: Discussionsupporting

confidence: 92%

“…Other EEG studies in OCD have reported decreased beta power (Karadag et al, 2003; Pogarell et al, 2006) particularly in frontal regions. An MEG study of spontaneous activity found an increase in fast oscillations (12.5–30 Hz) in OCD patients localized to left superior temporal gyrus (Maihofner et al, 2007). Such increases in high frequency rhythms are not commonly seen in psychiatric disorders.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Imaging of Thalamocortical Dysrhythmia in Neuropsychiatry

Schulman¹,

Cancro²,

Lowe³

et al. 2011

Front. Hum. Neurosci.

158

125

View full text Add to dashboard Cite

Abnormal brain activity dynamics, in the sense of a thalamocortical dysrhythmia (TCD), has been proposed as the underlying mechanism for a subset of disorders that bridge the traditional delineations of neurology and neuropsychiatry. In order to test this proposal from a psychiatric perspective, a study using magnetoencephalography (MEG) was implemented in subjects with schizophrenic spectrum disorder (n = 14), obsessive–compulsive disorder (n = 10), or depressive disorder (n = 5) and in control individuals (n = 18). Detailed CNS electrophysiological analysis of these patients, using MEG, revealed the presence of abnormal theta range spectral power with typical TCD characteristics, in all cases. The use of independent component analysis and minimum-norm-based methods localized such TCD to ventromedial prefrontal and temporal cortices. The observed mode of oscillation was spectrally equivalent but spatially distinct from that of TCD observed in other related disorders, including Parkinson's disease, central tinnitus, neuropathic pain, and autism. The present results indicate that the functional basis for much of these pathologies may relate most fundamentally to the category of calcium channelopathies and serve as a model for the cellular substrate for low-frequency oscillations present in these psychiatric disorders, providing a basis for therapeutic strategies.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Imaging of Thalamocortical Dysrhythmia in Neuropsychiatry

Schulman¹,

Cancro²,

Lowe³

et al. 2011

Front. Hum. Neurosci.

158

125

View full text Add to dashboard Cite

show abstract

“…Magnetoencephalographic experiments have also revealed abnormal activity in the left STG in patients with OCD [64]. The STG is involved in coupling visceral emotional responses with complex visual stimuli during a symptom provocation task [65].…”

Section: Discussionmentioning

confidence: 98%

Structural brain abnormalities correlate with clinical features in patients with drug-naïve OCD: A DARTEL-enhanced voxel-based morphometry study

Tang

Huang

et al. 2015

Behavioural Brain Research

View full text Add to dashboard Cite

“…Treatment response was further negatively related to the low alpha activity especially in the temporal structures and left insula. In OCD compared to healthy controls, the middle or superior temporal cortex was described as smaller [29,40] or thinner [41] and functional abnormalities have also been reported in this area [42]. The neighboring insula is implicated in a variety of neuropsychiatric disorders [43], including OCD [44].…”

Section: Discussionmentioning

confidence: 99%

Prediction of Treatment Response and the Effect of Independent Component Neurofeedback in Obsessive-Compulsive Disorder: A Randomized, Sham-Controlled, Double-Blind Study

et al. 2013

View full text Add to dashboard Cite

Aims: The goal of this study was to assess the effect of independent component neurofeedback (NFB) on EEG and clinical symptoms in patients with obsessive-compulsive disorder (OCD). Subsequently, we explored predictors of treatment response and EEG correlates of clinical symptoms. Methods: In a randomized, double-blind, parallel design, 20 inpatients with OCD underwent 25 sessions of NFB or sham feedback (SFB). NFB aimed at reducing EEG activity in an independent component previously reported abnormal in this diagnosis. Resting-state EEG recorded before and after the treatment was analyzed to assess its posttreatment changes, relationships with clinical symptoms and treatment response. Results: Overall, clinical improvement in OCD patients was not accompanied by EEG change as assessed by standardized low-resolution electromagnetic tomography and normative independent component analysis. Pre- to posttreatment comparison of the trained component and frequency did not yield significant results; however, in the NFB group, the nominal values at the downtrained frequency were lower after treatment. The NFB group showed significantly higher percentage reduction of compulsions compared to the SFB group (p = 0.015). Pretreatment higher amount of delta (1-6 Hz) and low alpha oscillations as well as a lower amount of high beta activity predicted a worse treatment outcome. Source localization of these delta and high beta oscillations corresponded with previous EEG resting-state findings in OCD patients compared to healthy controls. Conclusion: Independent component NFB in OCD proved useful in percentage improvement of compulsions. Based on our correlation analyses, we hypothesize that we targeted a network related to treatment resistance.

show abstract

Spontaneous magnetoencephalographic activity in patients with obsessive-compulsive disorder

Cited by 19 publications

References 37 publications

Imaging of Thalamocortical Dysrhythmia in Neuropsychiatry

Imaging of Thalamocortical Dysrhythmia in Neuropsychiatry

Structural brain abnormalities correlate with clinical features in patients with drug-naïve OCD: A DARTEL-enhanced voxel-based morphometry study

Prediction of Treatment Response and the Effect of Independent Component Neurofeedback in Obsessive-Compulsive Disorder: A Randomized, Sham-Controlled, Double-Blind Study

Contact Info

Product

Resources

About