Spontaneous meal patterns in female rats with and without access to running wheels

Eckel, Lisa A.; Houpt, Thomas A.; Geary, Nori

doi:10.1016/s0031-9384(00)00278-x

Cited by 141 publications

(136 citation statements)

References 34 publications

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“…One limitation of the current study is that the effects of exogenous hormone administration and/or gonadectomy were not examined. As noted earlier, studies in female rodents reported that ovariectomy and ovarian hormone replacement reliably influenced spontaneous food intake (Tarttelin and Gorski, 1971;Wade, 1975;Blaustein and Wade, 1976;Eckel et al, 2000). Further research will be necessary to clarify the conditions under which ovarian steroid hormones may influence food-maintained behavior in non-human primates.…”

Section: Gender Comparisons Of Food-maintained Respondingmentioning

confidence: 72%

“…In rodents, the estrus phase of the estrous cycle is characterized by declining levels of estradiol from peak levels in proestrus (Freeman, 1994). Food intake was lower during the estrus phase than at other phases of the estrous cycle (Tarttelin and Gorski, 1971;Eckel et al, 2000). Water intake also decreased significantly during estrus compared to other phases of the estrous cycle (Tarttelin and Gorski, 1971).…”

Section: Introductionmentioning

confidence: 99%

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Effects of gender and menstrual cycle phase on food-maintained responding under a progressive-ratio schedule in cynomolgus monkeys

Roth

Negus

Knudson

et al. 2005

Pharmacology Biochemistry and Behavior

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Clinical and preclinical data suggest that fluctuations in ovarian steroid hormones across the menstrual/estrous cycle influence spontaneous feeding behavior in females. The effects of gender, menstrual cycle phase, and ovarian hormone fluctuations on food-maintained responding under a progressive-ratio schedule were investigated in four female and three male cynomolgus monkeys. Females were studied across 21 menstrual cycles, and ovulatory cycles were defined by analysis of ovarian steroid hormone levels. Data were analyzed for the early and mid-follicular phase and the mid-and late-luteal phase of the menstrual cycle. Progressive-ratio break points for food were significantly higher in males than in females (p < 0.01). However, progressive-ratio break points did not vary consistently as a function of menstrual cycle phase during ovulatory cycles. There were no systematic patterns of progressive ratio break points in anovulatory menstrual cycles. Only one female monkey reached significantly higher break points during the mid-and late luteal phases in comparison to the mid-follicular phase of the menstrual cycle (p < 0.05). There was also a significant positive correlation between progressive-ratio break points and progesterone levels and a significant negative correlation with estradiol in that monkey. Although fluctuations in ovarian steroid hormones may influence food consumption under some conditions, consistent patterns of food-maintained responding were not detected during ovulatory menstrual cycles in cynomolgus monkeys.

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Section: Gender Comparisons Of Food-maintained Respondingmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Effects of gender and menstrual cycle phase on food-maintained responding under a progressive-ratio schedule in cynomolgus monkeys

Roth

Negus

Knudson

et al. 2005

Pharmacology Biochemistry and Behavior

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“…A meal was defined as any feeding bout of at least 0.35 g that was separated from other feeding bouts by at least 15 min. In previous studies, these criteria accounted for 97-99 % of daily food intake (e.g., [20]). Water intake was monitored by weighing water bottles (± 0.1 g) at specific intervals.…”

Section: Behavioral Measuresmentioning

confidence: 97%

The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle

Santollo

Eckel

2008

Physiology & Behavior

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Recently, it was shown that that the orexigenic effect of melanin concentrating hormone (MCH) is attenuated by estradiol treatment in ovariectomized (OVX) rats. This suggests that female rats may be less responsive than male rats to the behavioral effects of MCH. To investigate this hypothesis, the effects of lateral ventricular infusions of MCH on food intake, water intake, meal patterns, and running wheel activity were examined in male and female rats. To further characterize the impact of estradiol on MCH-induced food intake, female rats were OVX and tested with and without 17-β-estradiol benzoate (EB) replacement. In support of our hypothesis, food and water intakes following MCH treatment were greater in male rats, relative to female rats. Specifically, the orexigenic effect of MCH was maximal in male rats and minimal in EB-treated OVX rats. In both sexes, the orexigenic effect of MCH was mediated by a selective increase in meal size, which was attenuated in EB-treated OVX rats. MCH induced a short-term (2 h) decrease in wheel running that, unlike its effects on ingestive behavior, was similar in males and females. Thus, estradiol decreases some, but not all, of the behavioral effects of MCH. To examine the influence of endogenous estradiol, food intake was monitored following MCH treatment in ovarian-intact, cycling rats. As predicted by our findings in OVX rats, the orexigenic effect of MCH was attenuated in estrous rats, relative to diestrous rats. We conclude that the female rat's reduced sensitivity to the orexigenic effect of MCH may contribute to sex-and estrous cycle-related differences in food intake.

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“…Drinking behavior in the estrus phase was lesser than that in other phases [46]. Isoprenaline-induced water intake in the proestrus and estrus phases was lower than that in the other phases [47].…”

Section: Discussionmentioning

confidence: 72%

Effect of Systemic Estradiol Administration on Circadian Body Temperature and Activity Rhythms in Female Rats

Uchida¹,

Marui²,

Tokizawa³

et al. 2017

Anat Physiol

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The estrus cycle affects the circadian body temperature (T b ) and activity rhythms, and progesterone is related to these alterations. However, it is not clear whether estrogen (E 2 ) influences it. The present study examined whether E 2 affects the circadian T b and activity rhythm. Ovariectomized rats were implanted with a silastic plate with or without E 2 underneath the dorsal skin (E 2 (-) and E 2 (+)), and these along with sham operated rats (SH) were measured for T b and activity for 2 weeks. The mean T b was lower, and mean activity was higher in E 2 (+) than that in E 2 (-) in the day. In the dark phase, the slope of the relationship between the mean T b and activity in E 2 (-) was the greatest. The slope in E 2 (+) and SH was greater in the light phase than that in the dark phase. The daily peak of T b and activity was lower in E 2 (+) than that in E 2 (-). The appearance of the nadir in T b was later in E 2 (+) and SH than that in E 2 (-). The appearance of the peak in T b and activity was earlier in E 2 (+) and SH than that in E 2 (-). Thus, E 2 may modulate the circadian T b and activity rhythm in female rats.

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Spontaneous meal patterns in female rats with and without access to running wheels

Cited by 141 publications

References 34 publications

Effects of gender and menstrual cycle phase on food-maintained responding under a progressive-ratio schedule in cynomolgus monkeys

Effects of gender and menstrual cycle phase on food-maintained responding under a progressive-ratio schedule in cynomolgus monkeys

The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle

Effect of Systemic Estradiol Administration on Circadian Body Temperature and Activity Rhythms in Female Rats

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