Spontaneous mechanical and electrical activities of human calf musculature at rest assessed by repetitive single‐shot diffusion‐weighted MRI and simultaneous surface electromyography

Schwartz, Martin; Steidle, Günter; Martirosian, Petros; Ramos-Murguialday, Ander; Preißl, Hubert; Stemmer, Alto; Yang, Bin; Schick, Fritz

doi:10.1002/mrm.26921

Cited by 16 publications

(13 citation statements)

References 49 publications

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“…In another recent study, possible correlations between DWI and EMG on healthy volunteers could be identified (Surov et al., ). It was shown that spontaneous muscle activity can be detected on DWI and surface EMG in a similar fashion, and therefore this study is in good agreement with the present study that both modalities are linked to each other (Schwartz et al, ). We hereby present the first data regarding possible associations between ADC and EMG.…”

Section: Discussionsupporting

confidence: 93%

Associations between apparent diffusion coefficient and electromyography parameters in myositis—A preliminary study

Meyer¹,

Emmer

Kornhuber

et al. 2018

Brain and Behavior

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Objective MRI is widely used in several muscle disorders. Diffusion‐weighted imaging (DWI) is an emergent imaging modality sensitive to microstructural alterations in tissue. The apparent diffusion coefficient (ADC) is used to quantify the random motion of water molecules. Electromyography (EMG) is a clinically used diagnostic tool in myositis. The aim of this study was to elucidate possible associations between ADC values and EMG findings in myositis patients.MethodSeven patients (eight investigated muscles) with myositis (mean age 51.43 ± 19 years) were included in this study. The diagnosis was confirmed by histopathology in every case. DWI was obtained with a 1.5‐T scanner using two b‐values 0 and 1000 s/mm². In all patients, a needle electromyography (EMG) was performed within 3 days to the MRI. The following EMG parameters were studied: motor unit action potential (MUAP) amplitudes and durations, as well as pathological spontaneous activity. Spearman's correlation coefficient was used to analyze associations between investigated parameters.ResultsThe estimated mean ADC mean value was 1.51 ± 0.29 × 10−3 mm²/s, mean ADC min was 1.28 ± 0.27 × 10−3 mm²/s, and mean ADC max was 1.73 ± 0.28 × 10−3 mm²/s. Correlation analysis identified significant associations between ADC mean and duration of the MUAP (p = .78 P = .0279) and between ADC min and duration of the MUAP (p = .85, P = .01). There were no significant differences according to pathological spontaneous activity.Conclusion ADC mean and ADC min showed strong positive correlations with the duration of the MUAP in myositis patients. Both modalities might similarly reflect muscle fiber loss in myositis patients.

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Section: Discussionsupporting

confidence: 93%

Associations between apparent diffusion coefficient and electromyography parameters in myositis—A preliminary study

Meyer¹,

Emmer

Kornhuber

et al. 2018

Brain and Behavior

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“…This is remarkably similar to published estimates of human motor unit diameter based on scanning electromyography . Further studies have shown that these voids are usually preceded by electrical activity recorded using surface electromyography but have not determined the anatomical substrate in which they are generated . We hypothesized that the signal dropout was caused by the bulk movement of water resulting from the contraction of individual motor units rather than simple diffusion.…”

Section: Patient Id Age Yr Time Since Diagnosis Mo Als Classificatisupporting

confidence: 80%

Functional magnetic resonance imaging of human motor unit fasciculation in amyotrophic lateral sclerosis

Whittaker

Porcari

Braz

et al. 2019

Annals of Neurology

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A novel diffusion-weighted magnetic resonance imaging protocol sensitive to contraction of individual skeletal motor units was developed. We applied this technique to the lower limb muscles of 4 patients with confirmed amyotrophic lateral sclerosis (ALS) and 6 healthy controls. A 3-minute scan revealed florid fasciculation in ALS patients, involving both superficial and deep muscles, and at a frequency higher than in healthy controls. This novel imaging technique reveals hitherto unobtainable information on human motor unit structure and function, which may allow earlier diagnosis and recruitment to clinical trials.

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“…In a recent study, a strong correlation between visible SMAMs in DWI and electrical activities measured by surface electromyography at the skin surface was revealed. These findings provide evidence that SMAMs are related not only to undesired artifacts in diffusion‐weighted MRI, but also to spontaneous muscular activity potentially relevant to other fields of muscular research . Each SMAM in resting skeletal musculature seems to be a unique event related to a random spatial and temporal movement pattern visible in DWI .…”

Section: Introductionmentioning

confidence: 66%

“…Since SMAMs visible in DWI first are strongly correlated to preceding surface electromyography measurable electrical activities, second are assumed to be not caused by MR gradient switching and third have shown a distinct connection to anatomical characteristics such as fiber orientation, SMAMs seem to be clearly related to physiological muscular processes.…”

Section: Discussionmentioning

confidence: 99%

“…These findings provide evidence that SMAMs are related not only to undesired artifacts in diffusion-weighted MRI, but also to spontaneous muscular activity potentially relevant to other fields of muscular research. 2 Each SMAM in resting skeletal musculature seems to be a unique event related to a random spatial and temporal movement pattern visible in DWI. 1 According to Steidle and Schick, 1 SMAMs have a three-dimensional spatial extension measured by series of two-dimensional sagittal DWI and it has been revealed that the spatial extension is enlarged compared to transverse images.…”

Section: Introductionmentioning

confidence: 99%

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Volumetric assessment of spontaneous mechanical activities by simultaneous multi‐slice MRI techniques with correlation to muscle fiber orientation

et al. 2018

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The purpose of this work was assessment of volumetric characteristics of spontaneous mechanical activities in musculature (SMAMs) by diffusion-weighted simultaneous multi-slice (DW-SMS) imaging and spatial correlation to anatomical structure, as revealed by fusion to fiber tractographic information derived from diffusion-tensor imaging (DTI). The feasibility of using DW-SMS to image spontaneous events in human musculature was assessed by phantom measurements. Series of DW-SMS images and DTI datasets were recorded from the resting calf of three human subjects. Simultaneously recorded SMAMs in multiple slices were analyzed regarding spatial extension by the Kolmogorov-Smirnov test. Direct correlation of spatial distribution of SMAMs and fiber orientation was investigated by mapping of muscle fibers to multi-slice SMAM datasets. The DW-SMS strategy allows simultaneous assessment of SMAMs in several slices of resting skeletal musculature, since 73.9% of SMAM-affected volumes have shown SMAMs in multiple DW-SMS slices. Spatial extension of SMAMs was highly correlated over different simultaneously recorded DW-SMS slices, and affected areas followed the orientation of muscle fibers with a connectivity ratio up to 57.18 ± 14.80% based on event count and connectivity count maps. In 89.2% of all SMAM-affected datasets muscle fiber connectivity was shown in at least two adjacent slices. Direct correlation between SMAMs in human lower leg musculature and underlying anatomical structure was revealed by high muscle fiber connectivity (89.2%). SMAMs have shown a wide distribution along the longitudinal muscle direction (73.9% in multiple DW-SMS slices) with direct involvement of muscle fibers. Correlation between SMAMs in multiple DW-SMS slices and crossing muscular fiber tracts provides evidence that SMAMs result from physiological processes in musculature. Fusion of DW-SMS with DTI facilitates non-invasive studies of muscle fiber involvement in SMAMs in resting muscle.

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Spontaneous mechanical and electrical activities of human calf musculature at rest assessed by repetitive single‐shot diffusion‐weighted MRI and simultaneous surface electromyography

Cited by 16 publications

References 49 publications

Associations between apparent diffusion coefficient and electromyography parameters in myositis—A preliminary study

Associations between apparent diffusion coefficient and electromyography parameters in myositis—A preliminary study

Functional magnetic resonance imaging of human motor unit fasciculation in amyotrophic lateral sclerosis

Volumetric assessment of spontaneous mechanical activities by simultaneous multi‐slice MRI techniques with correlation to muscle fiber orientation

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