Spontaneous motility of the cervix in cyclic and ovariectomized ewes and changes induced by exogenous hormones

Garcia‐Villar, R.; Toutain, P. L.; Moré, J.; Ruckebusch, Y.

doi:10.1530/jrf.0.0660317

Cited by 26 publications

(26 citation statements)

References 16 publications

(17 reference statements)

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“…Con versely, PGE has been shown to stimulate the pregnant uterus [17], Therefore, depres sion of uterine motility as observed in some experiments cannot be connected with a di rect action of PGE on the uterus but may result from PGE-induced stimulation of both progesterone secretion by the corpus luteum and adenylate-cyclase activity which elicits corresponding rises in cAMP levels, a mechanism known to mediate uterine tocolysis. A mediation of this effect by a rise in progesterone and cAMP would be in agree ment with the fact that, when present, the depressive effect is relatively long-lasting (24-28 h), restricted to the uterus (the cervix is not inhibited by progesterone, for example during the luteal phase of the ovine estrous cycle [21]) and finally, devoid of direct dele terious effects on pregnancy.…”

Section: Discussionsupporting

confidence: 59%

“…Surgery was done between the 49th and the 65th day of pregnancy according to a procedure described elsewhere [21]. Electrodes were positioned on the pregnant horn(s) and on the cervix.…”

Section: Animals and Surgerymentioning

confidence: 99%

“…Throughout the course of the experiments, the ewes received no therapeutic treatment. Record ing procedures are described elsewhere [21]. EMGs were integrated and displayed 24 h/day on recorders.…”

Section: Recordsmentioning

confidence: 99%

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Evaluation of the Effects of Sennosides on Uterine Motility in the Pregnant Ewe

Garcia‐Villar¹

1988

Pharmacology

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The effects of sennosides on uterine motility were evaluated by electromyography in healthy adult ewes between day 70 and 120 of pregnancy to assess possible disturbances of the physiological pattern of contractility and eventual risks in pregnancy maintenance. At this stage of pregnancy, the ovine genital tract presented motility episodes of 6–8 min duration occurring at approximately hourly intervals. A dose-range study (10–160 mg/kg intracolonically) in 2 ewes showed that diarrhea was systematically obtained with doses > 20 mg/kg and was connected with a marked depression of both ileum and spiral colon motility. A standard dose of 60 mg/kg administered intracolonically 1–3 times at 7- to 10-day intervals to 12 ewes was used in the uterus studies. The experiments showed that sennosides did not stimulate uterine motility in the pregnant ewe, but slightly depressed it in some ewes. Cervix motility was never influenced. Intolerance of the drug was observed in half of the animals resulting mainly in anorexia or weakness and confirming a specific toxicity of senna in ruminants which is not known from other species. These effects were not related to uterine motility and pregnancy maintenance was normal in all ewes.

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Section: Discussionsupporting

confidence: 59%

“…Surgery was done between the 49th and the 65th day of pregnancy according to a procedure described elsewhere [21]. Electrodes were positioned on the pregnant horn(s) and on the cervix.…”

Section: Animals and Surgerymentioning

confidence: 99%

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Evaluation of the Effects of Sennosides on Uterine Motility in the Pregnant Ewe

Garcia‐Villar¹

1988

Pharmacology

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“…The recording procedures and electromyographic methods have been described elsewhere. 3 Drug Administration and Samples Collectiofipiramycin (Suanovil20, Rh8ne MBrieux, Lyon, France, containing 3200 IU/mg of the WHO standard) was injected iv by a jugular catheter as a single dose of 64 000 IU/kg (20 mgkg). Blood samples were collected from a catheter placed in the opposite jugular vein in heparinized tubes before injection (base-line sample, time 0 ) and a t 1,2,4,8,15,30,45, 60, and 90 min and 2,3,4,6,8,9,24,30, and 48 h post-injection.…”

Section: Methodsmentioning

confidence: 99%

Effect of Sexual Steroid Hormones on Spiramycin Disposition in Genital Tract Secretions of the Ewe

Cester¹,

Dubech²,

Toutain

1992

Journal of Pharmaceutical Sciences

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“…Furthermore, the methods utilized in most studies on uterine contractile activity were measurement of the contractile activity of the isolated myometrium in vitro [1][2][3][4][5][6][7][8] and electromyogram [9][10][11][12][13][14][15] and intrauterine pressure [16][17][18][19][20][21][22] recording in vivo. Although removal of the tissue from its natural environment and elimination of the numerous complex interactions make it easy to perform experiments and understand the underlying mechanisms, in vitro experiments have considerable limitations with respect to understanding the overall picture of uterine contractile activity control.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Observations of Uterine Contractions in Nonpregnant Dogs

Ibuki

Haga²,

Muramatsu³

et al. 1997

Biology of Reproduction

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Uterine contractile activity in nonpregnant conscious dogs was investigated based on 2- to 6-mo-long continuous recording by means of a chronically implanted force transducer. We found that nonpregnant uterine contractile activity could be classified into six major patterns: sporadic contractions, weak and strong tonic contractions, weak and strong phasic contractions, and phasic contraction bursts. The contractile patterns during proestrus and estrus were the most active, with strong phasic and tonic contractions and phasic contraction bursts. The phasic and tonic contractions were inhibited dose-dependently by a beta 2 adrenergic agonist, ritodrine, and reproduced by an alpha 2 adrenergic agonist, clonidine. In contrast, the cholinergic inhibitors atropine and hexamethonium did not affect the spontaneous occurrence of these contractions, although bethanechol evoked uterine contractions. Oxytocin and prostaglandin F2 alpha-induced contractions were phasic during estrus, whereas they showed tonic increases with phasic contractions during proestrus, diestrus, and anestrus, and these contractions did not resemble the spontaneous contractions. In conclusion, the nonpregnant uterus contracts continuously in harmony with the estrous cycle phases, and its contractile activity is enhanced by alpha adrenergic receptors and inhibited by beta 2 adrenergic receptors.

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Spontaneous motility of the cervix in cyclic and ovariectomized ewes and changes induced by exogenous hormones

Abstract: Summary. Continuous

Cited by 26 publications

References 16 publications

Evaluation of the Effects of Sennosides on Uterine Motility in the Pregnant Ewe

Evaluation of the Effects of Sennosides on Uterine Motility in the Pregnant Ewe

Effect of Sexual Steroid Hormones on Spiramycin Disposition in Genital Tract Secretions of the Ewe

Long-Term Observations of Uterine Contractions in Nonpregnant Dogs

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