2023
DOI: 10.3389/fmed.2023.1076690
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Spontaneous NETosis in diabetes: A role of hyperglycemia mediated ROS and autophagy

Abstract: Type 2-diabetes, particularly poorly controlled diabetes, is a risk factor for several infections such as lower respiratory tract and skin infections. Hyperglycemia, a characteristic downstream effect of poorly controlled diabetes, has been shown to impair the function of immune cells, in particular neutrophils. Several studies have demonstrated that hyperglycemia-mediated priming of NADPH oxidase results in subsequent elevated levels of reactive oxygen species (ROS). In healthy neutrophils, ROS plays an impor… Show more

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Cited by 12 publications
(8 citation statements)
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“…For example, some wound dressings provide natural ECM and deliver growth factors for wound healing, but it doesn't suppress the activity of metalloproteinases, so the therapeutic effect is limited [ 127 , 128 ]. Some studies scavenge ROS to alleviate oxidative stress in diabetic wounds but the continuous generation of ROS induced by bacteria infection and hyperglycemia is not taken into consideration [ [129] , [130] , [131] ]. Even though some studies aim to deliver multiple drugs to ensure combined pro-regenerative functions, the drug-releasing profiles fail to follow the real-time wound healing cascade.…”
Section: Discussionmentioning
confidence: 99%
“…For example, some wound dressings provide natural ECM and deliver growth factors for wound healing, but it doesn't suppress the activity of metalloproteinases, so the therapeutic effect is limited [ 127 , 128 ]. Some studies scavenge ROS to alleviate oxidative stress in diabetic wounds but the continuous generation of ROS induced by bacteria infection and hyperglycemia is not taken into consideration [ [129] , [130] , [131] ]. Even though some studies aim to deliver multiple drugs to ensure combined pro-regenerative functions, the drug-releasing profiles fail to follow the real-time wound healing cascade.…”
Section: Discussionmentioning
confidence: 99%
“…High pH, 40 hypertonicity, 41 hyperglycemia, 42 disorders of NETs degradation, and other pathological factors are also vital for the induction of NETosis. Due to different disease contexts, symptomatic treatment may help to more deeply explore the impact that the unique microenvironment of various diseases plays on NETosis.…”
Section: Pathological Factorsmentioning
confidence: 99%
“…43 Compared to non-diabetic patients, hyperglycemia increases the rate of NETosis and the release of NETs in patients with type 2 diabetes. 42 There may be inflammatory factors and other stimuli in the inflammatory environment that induce NETosis and aggravate inflammation. The colonic inflammatory environment of patients with ulcerative colitis releases interleukin (IL)-1β and locally regulated thrombus tissue factor in the development and DNA damage responses 1 protein to promote NETosis.…”
Section: Pathological Factorsmentioning
confidence: 99%
“…
Fig. 1 Common risk factors associated with cardiovascular disease and depression Various environmental factors such as obesity [ [5] , [6] , [7] , [8] ], physical inactivity [ 6 , 9 , 10 ], smoking [ [11] , [12] , [13] ], diabetes [ 14 , 15 ], stress [ 16 , 17 , 18 ] and chronic inflammation [ 5 , 7 ], which are also common risk factors for CVDs and depression, can regulate the expression/activity of NOXs.
…”
Section: Introductionmentioning
confidence: 99%
“…2 ; Table 1 ) [ 61 ]. It is noteworthy that the activity and expression of NOXs are regulated by obesity [ [5] , [6] , [7] , [8] ], physical inactivity [ 6 , 9 , 10 ], smoking [ [11] , [12] , [13] ], diabetes [ 14 , 15 ], stress [ 16 , 17 , 18 ] and chronic inflammation [ 5 , 7 ], which are also some of the common risk factors for CVDs and depression ( Fig. 1 ).…”
Section: Introductionmentioning
confidence: 99%