Spontaneous neurocognitive retrieval of patients with sub-acute ischemic stroke is associated with dietary protein intake

Aquilani, Roberto; Scocchi, Marco; Iadarola, Paolo; Viglio, Simona; Pasini, Evasio; Condello, Salvatore; Boschi, Federica; Pastoris, Ornella; Bongiorno, A; Verri, Manuela

doi:10.1179/147683010x12611460764002

Cited by 11 publications

(6 citation statements)

References 35 publications

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Section: Suppression Of Brain Protein Synthesis and Nutrition Intervesupporting

confidence: 56%

“…In further support of these data, we recently documented a positive correlation between spontaneous improvement of neurocognitive deficits and dietary protein intake and a negative correlation with the dietary carbohydrate:protein ratio in patients with subacute stroke. 23 When considering explanations for the positive influence of protein on brain function, the first point to keep in mind is that the types of cerebral proteins, 24 and hence the amino acid profile in the brain, 25 are influenced by the types of dietary proteins. We proposed 11,13,22,23 that multiple mechanisms may account for the efficacy of protein supplementation on brain function of patients with subacute stroke.…”

Section: Suppression Of Brain Protein Synthesis and Nutrition Intervementioning

confidence: 99%

“…When considering explanations for the positive influence of protein on brain function, the first point to keep in mind is that the types of cerebral proteins, 24 and hence the amino acid profile in the brain, 25 are influenced by the types of dietary proteins. We proposed 11 , 13 , 22 , 23 that multiple mechanisms may account for the efficacy of protein supplementation on brain function of patients with subacute stroke. These mechanisms, primed by increased cerebral availability of amino acids, 26 include a synergistic action between induced brain protein synthesis and rehabilitation procedures (Figure 1), 24 , 26 , 27 an improvement in neuron energy formation (Figure 2), 24 , 26 , 28 and better neurotransmitter synthesis (Figure 3).…”

Section: Suppression Of Brain Protein Synthesis and Nutrition Intervementioning

confidence: 99%

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Nutrition for Brain Recovery After Ischemic Stroke

Aquilani

Sessarego²,

Iadarola

et al. 2011

Nut in Clin Prac

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In patients who undergo rehabilitation after ischemic stroke, nutrition strategies are adopted to provide tube-fed individuals with adequate nutrition and/or to avoid the body wasting responsible for poor functional outcome and prolonged stay in the hospital. Investigations have documented that nutrition interventions can enhance the recovery of neurocognitive function in individuals with ischemic stroke. Experimental studies have shown that protein synthesis is suppressed in the ischemic penumbra. In clinical studies on rehabilitation patients designed to study the effects of counteracting or limiting this reduction of protein synthesis by providing protein supplementation, patients receiving such supplementation had enhanced recovery of neurocognitive function. Cellular damage in cerebral ischemia is also partly caused by oxidative damage secondary to free radical formation and lipid peroxidation. Increased oxidative stress negatively affects a patient's life and functional prognosis. Some studies have documented that nutrition supplementation with B-group vitamins may mitigate oxidative damage after acute ischemic stroke. Experimental investigations have also shown that cerebral ischemia changes synaptic zinc release and that acute ischemia increases zinc release, aggravating neuronal injury. In clinical practice, patients with ischemic stroke were found to have a lower than recommended dietary intake of zinc. Patients in whom daily zinc intake was normalized had better recovery of neurological deficits than subjects given a placebo. The aim of this review is to highlight those brain metabolic alterations susceptible to nutrition correction in clinical practice. The mechanisms underlying the relationship between cerebral ischemia and nutrition metabolic conditions are discussed.

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Section: Suppression Of Brain Protein Synthesis and Nutrition Intervesupporting

confidence: 56%

Section: Suppression Of Brain Protein Synthesis and Nutrition Intervementioning

confidence: 99%

Section: Suppression Of Brain Protein Synthesis and Nutrition Intervementioning

confidence: 99%

See 1 more Smart Citation

Nutrition for Brain Recovery After Ischemic Stroke

Aquilani

Sessarego²,

Iadarola

et al. 2011

Nut in Clin Prac

Self Cite

View full text Add to dashboard Cite

show abstract

“…Neurotransmitters are synthesized from amino acids, and the synthesis of new proteins is required for the formation of new cortical networks 5 . Of particular significance is that trials and observational data in adult patients with stroke and traumatic brain injury have demonstrated that protein supplementation results in improved motor and cognitive outcomes 3 , 4 , 6 , 7 . Infants and children with cerebral palsy are known to be at high risk for growth failure 8 .…”

mentioning

confidence: 99%

“…5 Of particular significance is that trials and observational data in adult patients with stroke and traumatic brain injury have demonstrated that protein supplementation results in improved motor and cognitive outcomes. 3,4,6,7 Infants and children with cerebral palsy are known to be at high risk for growth failure. 8 There is, however, a paucity of data linking the evidence of dietary protein and growth outcomes in this population.…”

mentioning

confidence: 99%