Spontaneous Ocular Findings and Esthesiometry / Tonometry Measurement in the Göttingen Minipig (Conventional and Microbiologically Defined)

Loget, Olivier

doi:10.1007/978-1-4615-1887-7_41

Cited by 8 publications

(3 citation statements)

References 4 publications

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“…Lens opacities, including suture line abnormalities, are described as a normal background lesion in the Göttingen minipig (Loget 1995; Loget and Saint-Macary 2000). According to Loget and Saint-Macary (2000), the background incidence of lens abnormalities in the Göttingen minipig is reported to be 2.8% for suture line abnormality, 8.3% for focal nuclear opacity, 19.4% for posterior cortical pinpoint opacity, and 8.3% for posterior capsular opacity (Loget and Saint-Macary 2000).…”

Section: Discussionmentioning

confidence: 99%

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Toxicity and Toxicokinetic Study of Subcutaneously Administered RPh201 in Minipigs

et al. 2018

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Mastic gum extracts are widely used as herbal remedies and are being tested for several clinical indications. Nevertheless, information on their safety is limited. RPh201 is an extract of the mastic gum, formulated and stabilized in a proprietary method, which is being developed as a novel drug candidate for neurological indications. The aim of this study was to assess the systemic toxic potential of RPh201, administered twice weekly by subcutaneous injections to minipigs, after 39 weeks of administration followed by a recovery period of 6 weeks. No clinical or dose-related signs were observed, but treatment-related findings were seen at the injection sites of the high-dose animals, composed of abscesses, chronic inflammation, and subcutaneous fibrosis. Abscesses >30 mm in size, graded as marked severity, were confined to the high-dose group and were considered as adverse. Minimal-slight subcutaneous and lymph nodes abscesses seen in control, low, and intermediate doses, related to the vehicle (cottonseed oil), were not considered as adverse. Additionally, minimal-to-slight cystic spaces or vacuolation related to the vehicle were observed in the skin, lymph nodes, kidney, and lungs. These findings were considered not to be adverse. The no-observed-adverse-effect level was considered to be 12.5 mg/kg/occasion.

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Section: Discussionmentioning

confidence: 99%

“…Lens focal nuclear opacities were reported in other animal species (e.g., dogs, rats, and Yucatan minipigs) and are nonprogressive and do not interfere with vision. It is probable that this abnormality appears later in life and should not be considered adverse (Loget 1995).…”

Section: Weeksmentioning

confidence: 99%

Toxicity and Toxicokinetic Study of Subcutaneously Administered RPh201 in Minipigs

et al. 2018

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“…The avascular cornea receives nutrients from the aqueous humor. [7][8][9] In nonclinical studies, corneal opacities, often reported as corneal dystrophy, are the most frequently reported spontaneous ocular finding in rabbits 10 and Sprague Dawley rats 11 and reported at various incidences depending on strain and age of rats and mice, [12][13][14][15][16][17][18] Syrian hamster, 12 Guinea pigs, 19 and beagle dogs 12,20,21 but are seldom reported in micromini-and mini-pigs 5,22,23 and cynomolgus monkeys. 24 These clinically reported opacities are sometimes associated with a variety of traumatic, environmental (light-induced), procedural (perianesthetic), metabolic/systemic (lipid), age-related or unknown events, and some may be a misdiagnosis or occasionally from drug-induced (phospholipidosis) or genetic-induced abnormalities including corneal dystrophy.…”

Section: Introductionmentioning

confidence: 99%

Corneal Dystrophy in Dutch Belted Rabbits as a Possible Model of Thiel-Behnke Subtype of Epithelial-Stromal TGFβ-Induced Corneal Dystrophy

Schuh¹,

Holve

Mundwiler

2020

Toxicol Pathol

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The International Committee for Classification of Corneal Dystrophies (IC3D) categorized corneal dystrophies in humans using anatomic, genotypic, and clinicopathologic phenotypic features. Relative to the IC3D classification, a review of the veterinary literature confirmed that corneal dystrophy is imprecisely applied to any corneal opacity and to multiple poorly characterized histologic abnormalities of the cornea in animals. True corneal dystrophy occurs in mice with targeted mutations and spontaneously in pet dogs and cats and in Dutch belted (DB) rabbits, but these instances lack complete phenotyping or genotyping. Corneal dystrophy in DB rabbits can be an important confounding finding in ocular toxicology studies but has only been described once. Therefore, the ophthalmology and pathology of corneal dystrophy in 13 DB rabbits were characterized to determine whether the findings were consistent with or a possible model of any corneal dystrophy subtypes in humans. Slit lamp and optical coherence tomography (OCT) imaging were used to characterize corneal dystrophy over 4 months in young DB rabbits. The hyperechoic OCT changes correlated with light microscopic findings in the anterior stroma, consisting of highly disordered collagen fibers and enlarged keratocytes. Histochemical stains did not reveal abnormal deposits. Small clusters of 8 to 16 nm diameter curly fibers identified by transmission electron microscopy were consistent with Thiel-Behnke (TBCD) subtype of epithelial-stromal transforming growth factor β-induced dystrophies. Sporadic corneal dystrophy in DB rabbits appears to be a potential animal model of TBCD, but genotypic characterization will be required to confirm this categorization.

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Toxicologic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment

Schafer¹,

Render²

2012

Assessing Ocular Toxicology in Laboratory Animals

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Spontaneous Ocular Findings and Esthesiometry / Tonometry Measurement in the Göttingen Minipig (Conventional and Microbiologically Defined)

Cited by 8 publications

References 4 publications

Toxicity and Toxicokinetic Study of Subcutaneously Administered RPh201 in Minipigs

Toxicity and Toxicokinetic Study of Subcutaneously Administered RPh201 in Minipigs

Corneal Dystrophy in Dutch Belted Rabbits as a Possible Model of Thiel-Behnke Subtype of Epithelial-Stromal TGFβ-Induced Corneal Dystrophy

Toxicologic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment

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