Spontaneous Ocular Squamous Cell Carcinoma in Twin Goats: Pathological and Biomolecular Studies

Marà, M.; Guardo, Giovanni Di; Venuti, Aldo; Marruchella, Giuseppe; Palmieri, Chiara; Rugeriis, M. De; Petrizzi, Lucio; Simeone, Paola; Rizzo, Consuelo; Salda, Leonardo Della

doi:10.1016/j.jcpa.2004.06.007

Cited by 11 publications

(8 citation statements)

References 9 publications

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“…Neoplastic epithelial cells on SCC demonstrated variable degrees of squamous differentiation, forming islands, cords or trabeculae in dermis or submucosa associated or not to the proliferation and thickening of the epidermis (Ramos et al, 2007). Histopathological findings in this report were similar to those described by other authors (Stannard & Pulley, 1978;Mendez et al, 1997;Mara et al, 2005;Fayza et al, 2006;Radostitis et al, 2007;Abu-Seida, 2015).…”

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confidence: 91%

Perineal squamous cell carcinoma in a goat: a case report

Farjanikish¹

2017

BJVM

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SummaryFarjanikish, G., 2017. Perineal squamous cell carcinoma in a goat: A case report. Bulg. J. Vet. Med., 20, No 3,[281][282][283][284][285][286] A 4.5-year old female native Iranian goat was presented with history of an irregularly shaped and cauliflower-like non ulcerated mass that affected the perineum which gradually increased in size. The tumour covered the entire orifice of the anus and extended to the dorsal aspect of the vulva. The mass were excised from the base. On cut-section, reddish white fleshy soft surface with 4×3.5×1 cm dimensions was observed. The enlarging tissue appeared 3 months earlier to presentation as a small neoplastic tissue. The peripheral lymph nodes were normal. There was no evidence of another cutaneous lesion or of metastasis to other organs. Histopathological examination revealed a welldifferentiated squamous cell carcinoma displaying central pearls of keratin and a dense fibrous stroma. The tumour cell was large and had an abundant eosinophilic cytoplasm with slightly enlarged hyperchromatic nuclei. They will often produce large amounts of keratin, resulting in the formation of extracellular keratin pearls. Tumour cells showed hyperchromatism and mitotic figure in some areas. Based on histopathological characteristics the tumour was diagnosed as squamous cell carcinoma.

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confidence: 91%

Perineal squamous cell carcinoma in a goat: a case report

Farjanikish¹

2017

BJVM

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“…biomolecular techniques. One year after the onset of ocular SCCs, which had been previously described [20], multiple cutaneous and additional ocular neoplasms were identified in both animals. Such tumours were histologically classified as multiple cutaneous fibropapillomas and SCCs (particularly located in periocular and perianal skin of both animals), one malignant melanoma of periocular skin, as well as one ocular fibrosarcoma.…”

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confidence: 53%

“…The very low number of positive cells may also explain the previous negative results on ocular neoplasms from the same animals [20].…”

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confidence: 87%

“…Ten microlitres of each samples were used as template for PCR amplification with the consensus primers MY09/MY11 that are able to amplify part of the L1 region of a large number of PV, as previously reported [20]. In all neoplastic tissue samples from both animals a product of the predicted length (450 bp) was detected in ethidium bromide-stained 3% Nu-Sieve agarose gel.…”

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confidence: 99%

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Papillomaviruses in Multiple Tumours of Twin Goats

Simeone¹,

Romanucci²,

Rizzo³

et al. 2008

TOVSJ

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“…In the field of veterinary ophthalmology, caprine research has been sporadic and is often related to comparative or educational research for human ophthalmology 1–21 . Documentation of ophthalmic examination findings in various species, including normal intraocular pressure estimates and measurements of tear production, helps to establish references for clinical cases as well as investigative research.…”

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confidence: 99%