Spontaneous osteonecrosis of the knee (SONK): The role of MR imaging in predicting clinical outcome

Husain, Rola; Nesbitt, Jared; Tank, Dharmesh; Verastegui, Marco Oriundo; Gould, Elaine S.; Huang, Mingqian

doi:10.1016/j.jor.2020.11.014

Cited by 13 publications

(13 citation statements)

References 21 publications

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Section: Discussionmentioning

confidence: 99%

“…Abnormalities of subchondral bone are strongly associated with cartilage degeneration in OA, which can be secondary to SIFK. 5 Therefore, these progressive changes lead to a plausible assumption that cartilage in SIFK and OA undergo a similar degenerative process. In the present study, we reveal for the first time that cell type subpopulations and transcriptomic profiling of the articular cartilage in SIFK patients are completely different from that in normal and OA patients at the single-cell level.…”

Section: Discussionmentioning

confidence: 99%

“…Abnormalities of subchondral bone have been demonstrated to play a fundamental role in mediating cartilage degeneration in osteoarthritis (OA), which can be secondary to SIFK. 5 In addition, changes in the medial meniscus (tear and/or extrusion) and/or subchondral bone insufficiency fracture might result in massive stress loading on the cartilage. Therefore, a previous study emphasized the need for assessment of the cartilaginous coating by means of arthroscopy before instituting treatment for SIFK.…”

Section: Introductionmentioning

confidence: 99%

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Single-Cell RNA Sequencing Reveals Transcriptional Changes in the Cartilage of Subchondral Insufficiency Fracture of the Knee

Wang¹,

Li²,

Miao³

et al. 2022

JIR

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Subchondral insufficiency fracture of the knee (SIFK) is a common cause of knee joint pain that mainly afflicts the elderly. Until now, how a sudden insufficiency fracture of subchondral bone affects the transcriptomic profiles of cartilage in SIFK and OA patients are largely unknown. Methods: Single-cell RNA sequencing (scRNA-seq) was used to identify various cell subsets and evaluate transcriptomic differences in cartilage of SIFK and OA patients. In addition, the above findings were confirmed by histological evaluation and immunohistochemical (IHC) staining. Results: We found that the transcriptomic profiles of cartilage in the SIFK patient was completely different from those of normal and OA patients. Accordingly, several novel cell clusters with activation of hypoxia and endochondral ossification signaling were identified in the SIFK cartilage. Chondrocyte trajectories analysis and IHC staining revealed that transcription factors including TCF4 were found to be highly up-regulated during the occurrence of SIFK, which might drive the reactive formation of cartilage and fibrous tissue and the activation of endochondral ossification. Conclusion: This is the first report to elucidate the transcriptomic alterations and distinct cell type subpopulations in the cartilage of SIFK and OA by the use of scRNA-seq, which provides a new insight in the understanding of the initiation and progression of SIFK.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Single-Cell RNA Sequencing Reveals Transcriptional Changes in the Cartilage of Subchondral Insufficiency Fracture of the Knee

Wang¹,

Li²,

Miao³

et al. 2022

JIR

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“…Recent studies have shown an incidence of 3.4% among patients above 50 years of age and 9.4% among patients older than 65 years, with predominant affection of females compared with males by almost three to five times [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The clinical importance of this pathology of the knee focuses on structural changes that exert influence on the subchondral bone and articular cartilage [ 1 , 3 ]. Houpt et al reported, in a review of SPONK, that the most common site of involvement is the MFC, followed by the medial tibial plateau and last, the lateral femoral condyle [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Osteonecrosis of the Knee: State of the Art

Serrano

Saseendar²,

Shanmugasundaram³

et al. 2022

JCM

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Osteonecrosis is a terrible condition that can cause advanced arthritis in a number of joints, including the knee. The three types of osteonecrosis that can affect the knee are secondary, post-arthroscopic, and spontaneous osteonecrosis of the knee (SPONK). Regardless of osteonecrosis classification, treatment for this condition seeks to prevent further development or postpone the onset of knee end-stage arthritis. Joint arthroplasty is the best course of action whenever there is significant joint surface collapse or there are signs of degenerative arthritis. The non-operative options for treatment at the moment include observation, nonsteroidal anti-inflammatory medications (NSAIDs), protective weight bearing, and analgesia if needed. Depending on the severity and type of the condition, operational procedures may include unilateral knee arthroplasty (UKA), total knee arthroplasty (TKA), or joint preservation surgery. Joint preservation techniques, such as arthroscopy, core decompression, osteochondral autograft, and bone grafting, are frequently used in precollapse and some postcollapse lesions, when the articular cartilage is typically unaffected and only the underlying subchondral bone is affected. In contrast, operations that try to save the joint following significant subchondral collapse are rarely successful and joint replacement is required to ease discomfort. This article’s goal is to summarise the most recent research on evaluations, clinical examinations, imaging and various therapeutic strategies for osteonecrosis of the knee, including lesion surveillance, medicines, joint preservation methods, and total joint arthroplasty.

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Systemic and Localized Inflammatory Diseases of Older Adults

Malkana¹,

Kerr²

2021

Rheumatology for Primary Care Providers

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Spontaneous osteonecrosis of the knee (SONK): The role of MR imaging in predicting clinical outcome

Cited by 13 publications

References 21 publications

Single-Cell RNA Sequencing Reveals Transcriptional Changes in the Cartilage of Subchondral Insufficiency Fracture of the Knee

Single-Cell RNA Sequencing Reveals Transcriptional Changes in the Cartilage of Subchondral Insufficiency Fracture of the Knee

Spontaneous Osteonecrosis of the Knee: State of the Art

Systemic and Localized Inflammatory Diseases of Older Adults

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