2018
DOI: 10.1016/j.enzmictec.2017.09.006
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Spontaneous pepsin C-catalyzed activation of human pepsinogen C in transgenic rice cell suspension culture: Production and characterization of human pepsin C

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Cited by 15 publications
(7 citation statements)
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“…Plants have recently received considerable attention as a platform for protein production due to their unique characteristics, which include high scalability and low capital investment required for infrastructure. Moreover, protein production in plants is compatible with green technology, pathogen and endotoxin-free, and, most importantly, cost-effective and widely acceptable to society (Holtz et al, 2015;Islam et al, 2018;Schillberg et al, 2003).…”
Section: Introductionmentioning
confidence: 99%
“…Plants have recently received considerable attention as a platform for protein production due to their unique characteristics, which include high scalability and low capital investment required for infrastructure. Moreover, protein production in plants is compatible with green technology, pathogen and endotoxin-free, and, most importantly, cost-effective and widely acceptable to society (Holtz et al, 2015;Islam et al, 2018;Schillberg et al, 2003).…”
Section: Introductionmentioning
confidence: 99%
“…44,45 After taking PPI, gastric acid secretion is reduced, and the pH in the stomach rises to 4.0 or higher, inhibiting the activation of pepsinogen. 41,46 The current basic principle of drug therapy against GERD is to reduce gastric acid secretion and indirectly reduce the production of pepsin, thereby reducing the amount of gastric acid and pepsin refluxed to the esophagus, throat and other parts, resulting in significantly reduced clinical symptoms and the mucosa damages to the reflux site in GERD patients. 6,14,15 This study showed that for NERD patients, the positive rate of salivary pepsin test was significantly higher than the pathologic reflux as determined by 24-hour pH monitoring (71.9% vs 43.8%), suggesting that salivary pepsin test can complement or combine with the 24-hour pH monitoring and improve the efficiency in the diagnosis of GERD.…”
Section: Discussionmentioning
confidence: 99%
“…The His×6 tag positioned immediately after the bdSENP1 cleavage site in the recombinant protein was used for affinity purification of proteins produced in plant cell extracts. This approach produced His:hLIF at a yield of approximately 32.49 µg/g FW leaf tissue at near homogeneity (Nausch et al, 2012;Sabalza et al, 2014;Islam et al, 2018;Islam et al, 2019a).…”
Section: Discussionmentioning
confidence: 99%