Spontaneous perforation of jejunal gastrintestinal stromal tumour (gist). Case report and review of literature

Roy, Somsubhra Datta; Khan, Dawood; De, Krishna K; De, Utpal

doi:10.1186/1749-7922-7-37

Cited by 25 publications

(25 citation statements)

References 6 publications

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“…There are only 15 cases of perforated jejunal GIST reported in literature so far. [26] Our case was peculiar in that, the perforation was contained by the tumor itself. With the large size, location in jejunum, high mitotic index, advanced age of the patient and dense adhesions to surrounding structure, the prognosis of our case needs to be watched.…”

Section: Discussionmentioning

confidence: 75%

“…[24] The treatment modality is primarily surgical, ensuring the complete removal of the tumor with involved neighboring structures giving a clear surgical margin. Roy et al [26] suggests the use of distilled water for peritoneal lavage after surgery as it has a cytolytic activity on the tumor cells and hence prevent peritoneal spillage. The discovery of tyrosine kinase receptor mutations in the pathogenesis has led to the usage of tyrosine kinase inhibitor, imatinib mesylate as an adjuvant to surgery and in inoperable and recurrent cases.…”

Section: Discussionmentioning

confidence: 99%

“…Response of the tumor to conventional chemotherapy is poor. [26] The most common histologic subtype is the spindle cell variety. Others include epithelioid type and mixed spindle and epithelioid type.…”

Section: Discussionmentioning

confidence: 99%

“…Positron Emission Tomography (PET) is a very good tool for postoperative follow up of patients on imatinib. [26] The median survival period is 9 to 16 months in case of recurrence.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Small Bowel Gist: Case Reports and Review of Literature

J¹,

Jeyakumar²,

R³

et al. 2014

jemds

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GIST may present as an abdominal mass, obstruction, haemorrhage in the gastrointestinal tract or perforation. Literature on perforated jejunal GIST is scarce. Here by, reporting 2 cases of jejunal GIST. Perforated jejunal GIST in an elderly lady, who presented with mass abdomen. En-bloc resection of the tumor giving a clear margin was done. Immunohistochemistry showed a GIST of aggressive behavior and a case jejunal GIST in a young patient who presented with pain in abdomen. Resection of the jejunal segment containing mass and end to end anastomosis done. Immunohistochemistry showed intermediate type. Both the patients are undergoing adjuvant therapy with imatinib mesylate. A comprehensive review on GIST is being attempted.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Positron Emission Tomography (PET) is a very good tool for postoperative follow up of patients on imatinib. [26] The median survival period is 9 to 16 months in case of recurrence.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Small Bowel Gist: Case Reports and Review of Literature

J¹,

Jeyakumar²,

R³

et al. 2014

jemds

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show abstract

“…6 If we go through the literature there are cases reported on perforation of jejunal GIST. 7 Skipworth, J.R . etal described first gastric GIST perforation and given review on the literature available till now.…”

Section: Discussionmentioning

confidence: 99%

Perforation of gastric gastrointestinal stromal tumor: A rare phenomenon & review of literature

Agrawal¹,

Wasnik²,

Yede³

et al. 2014

Int J of Biomed & Adv Res

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Gastrointestinal stromal tumors: a comprehensive radiological review

Inoue

Ota²,

Yamasaki

et al. 2022

Jpn J Radiol

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Gastrointestinal stromal tumors (GISTs) originating from the interstitial cells of Cajal in the muscularis propria are the most common mesenchymal tumor of the gastrointestinal tract. Multiple modalities, including computed tomography (CT), magnetic resonance imaging (MRI), fluorodeoxyglucose positron emission tomography, ultrasonography, digital subtraction angiography, and endoscopy, have been performed to evaluate GISTs. CT is most frequently used for diagnosis, staging, surveillance, and response monitoring during molecularly targeted therapy in clinical practice. The diagnosis of GISTs is sometimes challenging because of the diverse imaging findings, such as anatomical location (esophagus, stomach, duodenum, small bowel, colorectum, appendix, and peritoneum), growth pattern, and enhancement pattern as well as the presence of necrosis, calcification, ulceration, early venous return, and metastasis. Imaging findings of GISTs treated with antineoplastic agents are quite different from those of other neoplasms (e.g. adenocarcinomas) because only subtle changes in size are seen even in responsive lesions. Furthermore, the recurrence pattern of GISTs is different from that of other neoplasms. This review discusses the advantages and disadvantages of each imaging modality, describes imaging findings obtained before and after treatment, presents a few cases of complicated GISTs, and discusses recent investigations performed using CT and MRI to predict histological risk grade, gene mutations, and patient outcomes.

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Spontaneous perforation of jejunal gastrintestinal stromal tumour (gist). Case report and review of literature

Cited by 25 publications

References 6 publications

Small Bowel Gist: Case Reports and Review of Literature

Small Bowel Gist: Case Reports and Review of Literature

Perforation of gastric gastrointestinal stromal tumor: A rare phenomenon & review of literature

Gastrointestinal stromal tumors: a comprehensive radiological review

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