Spontaneous Peritoneal Malignant Mesothelioma in a Geriatric Japanese Macaque (Macaca fuscata)

Yamate, Jyoji; Tomita, A.; Kuwamura, Mitsuru; Mitsunaga, Fusako; Nakamura, Shin

doi:10.1538/expanim.56.155

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…Other rare intestinal neoplasms include a peritoneal mesothelioma associated with massive ascites in a Japanese macaque (M. fuscata) (Yamate et al, 2007), rectal adenocarcinoma in a capped langur (Presbytis pileata) (Yanai et al, 1994), a soft tissue sarcoma in a fat-tailed dwarf lemur (Remick et al, 2009), and a carcinoid tumor of the small intestine in a cynomolgus macaque (Lau and Spinelli, 1970).…”

Section: Tumors Of the Digestive Systemmentioning

confidence: 99%

Neoplasia and Proliferative Disorders of Nonhuman Primates

Miller¹

2012

Nonhuman Primates in Biomedical Research

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Section: Tumors Of the Digestive Systemmentioning

confidence: 99%

Neoplasia and Proliferative Disorders of Nonhuman Primates

Miller¹

2012

Nonhuman Primates in Biomedical Research

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“…: women having laundered their husband's overalls) and non-occupational "environmental" exposure [ 9 ]. Idiopathic or spontaneous mesothelioma can also occur in the absence of any exposure to asbestos in both animals [ 10 ] and humans [ 8 ], and a recent review suggests a spontaneous mesothelioma rate in humans of around one per million [ 11 ].…”

Section: Epidemiology and Aetiologymentioning

confidence: 99%

Malignant mesothelioma

Moore

Parker

Wiggins

2008

Orphanet J Rare Dis

116

111

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Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium) of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis. The exact prevalence is unknown but it is estimated that mesotheliomas represent less than 1% of all cancers. Its incidence is increasing, with an expected peak in the next 10-20 years. Pleural malignant mesothelioma is the most common form of mesothelioma. Typical presenting features are those of chest pain and dyspnoea. Breathlessness due to a pleural effusion without chest pain is reported in about 30% of patients. A chest wall mass, weight loss, sweating, abdominal pain and ascites (due to peritoneal involvement) are less common presentations. Mesothelioma is directly attributable to occupational asbestos exposure with a history of exposure in over 90% of cases. There is also evidence that mesothelioma may result from both para-occupational exposure and non-occupational "environmental" exposure. Idiopathic or spontaneous mesothelioma can also occur in the absence of any exposure to asbestos, with a spontaneous rate in humans of around one per million. A combination of accurate exposure history, along with examination radiology and pathology are essential to make the diagnosis. Distinguishing malignant from benign pleural disease can be challenging. The most helpful CT findings suggesting malignant pleural disease are 1) a circumferential pleural rind, 2) nodular pleural thickening, 3) pleural thickening of > 1 cm and 4) mediastinal pleural involvement. Involvement of a multidisciplinary team is recommended to ensure prompt and appropriate management, using a framework of radiotherapy, chemotherapy, surgery and symptom palliation with end of life care. Compensation issues must also be considered. Life expectancy in malignant mesothelioma is poor, with a median survival of about one year following diagnosis.

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“…In Japanese macaques, odontoameloblastoma, basal cell tumor, and peritoneal malignant mesothelioma have been recorded. 17,18,20 This case was the first report on littoral cell angioma of the spleen in a macaque.…”

Section: Differential Diagnosismentioning

confidence: 86%

Vasoformative Disorder, Resembling Littoral Cell Angioma, of the Spleen in a Geriatric Japanese Macaque(Macaca fuscata)

et al. 2009

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Abstract.A 30-year-old female Japanese macaque showed marked splenomegaly. The enlarged spleen consisted of neoplastic proliferation of anastomosing vascular channels resembling morphologic structures of red pulp sinuses; occasionally, papillary fronds were seen in dilated channels. Immunohistochemically, the lining cells reacted to both endothelial cell (von Willebrand factor) and macrophage (macrophage scavenger receptor class A) markers, indicating features of littoral cells of the spleen. Based on the pathologic characteristics, particularly the presence of neoplastic cells with macrophage/histiocyte-like attributes, this tumor was regarded as littoral cell angioma; this is a rare benign splenic vascular tumor.

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Spontaneous Peritoneal Malignant Mesothelioma in a Geriatric Japanese Macaque (Macaca fuscata)

Cited by 11 publications

References 24 publications

Neoplasia and Proliferative Disorders of Nonhuman Primates

Neoplasia and Proliferative Disorders of Nonhuman Primates

Malignant mesothelioma

Vasoformative Disorder, Resembling Littoral Cell Angioma, of the Spleen in a Geriatric Japanese Macaque(Macaca fuscata)

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