Spontaneous Physical Activity Defends Against Obesity

Kotz, Catherine M.; Perez‐Leighton, Claudio E.; Teske, Jennifer A.; Billington, Charles J.

doi:10.1007/s13679-017-0288-1

Cited by 46 publications

(55 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More physical activities can decrease body weight. One related study supported the finding that all physical activity burns calories, including spontaneous physical activity, which could be manipulated to burn calories, defend against weight gain and reduce excess adiposity [25]. Surprisingly, young adults with high education levels are more likely to gain more weight than those with lower education levels.…”

Section: Discussionmentioning

confidence: 92%

Trends in the prevalence of obesity among young Thai men and associated factors: from 2009 to 2016

et al. 2019

View full text Add to dashboard Cite

Background The prevalence of obesity has been increasing in both males and females worldwide. In Thailand, the National Health Examination Surveys reported that the prevalence of obesity (body mass index (BMI) ≥30 kg/m 2 ) among Thai male adults aged 20–59 years increased from 1.7% in 1991 to 6.8% in 2009. Obesity has been confirmed to lead to health problems, including noncommunicable diseases. In the present study, we report trends in the prevalence of obesity among new conscripts from 2009 to 2016. We also investigated the associated factors of obesity. Methods Serial cross-sectional studies were conducted from 2009 to 2016 among male Royal Thai Army (RTA) conscripts whose weight and height had been measured to determine BMI after being inducted. Each subject completed a detailed risk factor questionnaire. Obesity was defined as BMI ≥ 30 kg/m 2 . Results A total of 26,540 young Thai males conscripted into the RTA were included in this study. The prevalence of obesity was 2.2% in 2009, 3.4% in 2010, 2.5% in 2011, 2.9% in 2012, 3.4% in 2013, 4.4% in 2014, 5.0% in 2015, and 4.8% in 2016 ( P for trend < 0.0001). The independent risk factors for obesity were coming from the north central and south regions compared with the northeast, higher education level, indoor occupation and no regular exercise. Conclusions Our data emphasized that obesity constitutes a serious problem among young Thai men. We could apply these findings in military units to other groups at any age. Regular exercise should be provided to young adults and other age groups to slow the process of obesity, so that associated complications, especially noncommunicable diseases, will cease.

show abstract

Section: Discussionmentioning

confidence: 92%

Trends in the prevalence of obesity among young Thai men and associated factors: from 2009 to 2016

et al. 2019

View full text Add to dashboard Cite

show abstract

“…This suggests that triggered lipogenesis based on the mTOR-SREBPB1 signaling pathway may constitute a significant part of the molecular mechanism underlying genetically determined high BMR, which acts as a compensatory mechanism lowering propensity to the detrimental effects of western-type diet and sedentary lifestyle. 12 16 45 Conversely, a reduction in metabolic rate may stimulate weight gain, excess adiposity, and favor the development of IR and T2D.…”

Section: Discussionmentioning

confidence: 99%

Low basal metabolic rate as a risk factor for development of insulin resistance and type 2 diabetes

Maciak

Sawicka

Sadowska

et al. 2020

BMJ Open Diab Res Care

View full text Add to dashboard Cite

IntroductionIdentification of physiological factors influencing susceptibility to insulin resistance and type 2 diabetes (T2D) remains an important challenge for biology and medicine. Numerous studies reported energy expenditures as one of those components directly linked to T2D, with noticeable increase of basal metabolic rate (BMR) associated with the progression of insulin resistance. Conversely, the putative link between genetic, rather than phenotypic, determination of BMR and predisposition to development of T2D remains little studied. In particular, low BMR may constitute a considerable risk factor predisposing to development of T2D.Research design and methodsWe analyzed the development of insulin resistance and T2D in 20-week-old male laboratory mice originating from three independent genetic line types. Two of those lines were subjected to divergent, non-replicated selection towards high or low body mass-corrected BMR. The third line type was non-selected and consisted of randomly bred animals serving as an outgroup (reference) to the selected line types. To induce insulin resistance, mice were fed for 8 weeks with a high fat diet; the T2D was induced by injection with a single dose of streptozotocin and further promotion with high fat diet. As markers for insulin resistance and T2D advancement, we followed the changes in body mass, fasting blood glucose, insulin level, lipid profile and mTOR expression.ResultsWe found BMR-associated differentiation in standard diabetic indexes between studied metabolic lines. In particular, mice with low BMR were characterized by faster body mass gain, blood glucose gain and deterioration in lipid profile. In contrast, high BMR mice were characterized by markedly higher expression of the mTOR, which may be associated with much slower development of T2D.ConclusionsOur study suggests that genetically determined low BMR makeup involves metabolism-specific pathways increasing the risk of development of insulin resistance and T2D.

show abstract

“…The epidemic of obesity and its comorbidities represents an increasingly worrisome medical and economic burden according to WHO reports [1]. Several strategies are available for weight loss and maintenance, such as the modification of lifestyle (diet and physical activity), pharmacology and surgery [2][3][4][5][6][7][8][9]. Many dietary patterns have been proposed throughout the years, and although several authors tried to determine what was best, it is now acknowledged that there is no optimal choice for each patient both efficacy-and safety-wise, and the treatment should be tailored to the needs, habits, and clinical condition [10].…”

Section: Introductionmentioning

confidence: 99%

Very Low-Calorie Ketogenic Diet: A Safe and Effective Tool for Weight Loss in Patients with Obesity and Mild Kidney Failure

Bruci¹,

et al. 2020

View full text Add to dashboard Cite

Very low-calorie ketogenic diets (VLCKD) are an effective and increasingly used tool for weight loss. Traditionally considered high protein, ketogenic diets are often looked at with concern by clinicians due to the potential harm they pose to kidney function. We herein evaluated the efficacy and safety of a VLCKD in patients with obesity and mild kidney failure. A prospective observational real-life study was conducted on ninety-two patients following a VLCKD for approximately 3 months. Thirty-eight had mild kidney failure and fifty-four had no renal condition and were therefore designated as control. Anthropometric parameters, bioelectrical impedance and biochemistry data were collected before and at the end of the dietary intervention. The average weight loss was nearly 20% of initial weight, with a significant reduction in fat mass. We report an improvement of metabolic parameters and no clinically relevant variation regarding liver and kidney function. Upon stratification based on kidney function, no differences in the efficacy and safety outcomes were found. Interestingly, 27.7% of patients with mild renal failure reported normalization of glomerular filtrate after dietary intervention. We conclude that, when conducted under the supervision of healthcare professionals, a VLCKD is an effective and safe treatment for weight loss in patients with obesity, including those affected by mild kidney failure.

show abstract

Spontaneous Physical Activity Defends Against Obesity

Cited by 46 publications

References 103 publications

Trends in the prevalence of obesity among young Thai men and associated factors: from 2009 to 2016

Trends in the prevalence of obesity among young Thai men and associated factors: from 2009 to 2016

Low basal metabolic rate as a risk factor for development of insulin resistance and type 2 diabetes

Very Low-Calorie Ketogenic Diet: A Safe and Effective Tool for Weight Loss in Patients with Obesity and Mild Kidney Failure

Contact Info

Product

Resources

About