Spontaneous Pinealoma in a Male Crj:CD(SD)IGS Rat.

Furukawa, Satoshi; Kobayashi, Kiyoshi; Usuda, Koji; Tamura, Tohru; Miyamoto, Yasuo; Hayashi, Kenichi; Ikeyama, Seiichi; Goryo, Masanobu; Okada, Kōsuke

doi:10.1292/jvms.61.41

Cited by 4 publications

(7 citation statements)

References 8 publications

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“…( Al Zubaidy and Malinowski 1984 ; Botts et al 1994 ; Capen et al 2001 ; Coca et al 1992 ; Fraser 1986 ; Furukawa et al 1999 ; Götz et al 1992 ; Heath and Winokur 1998 ; Hirato and Nakazato 2001 ; Jouvet et al 2006 ; Koestner and Solleveld 1996 ; Korf et al 1990 ; Krinke et al 1985 ; Krinke et al 2000 ; Maekawa et al 1984 ; Rubinstein 1972 ; Schachner et al 1984 ; Treumann et al 2015 ; Vogel and Fuller 2003 ; Walker et al 1994 ; Yamamoto et al 1991 )…”

Section: Pineal Glandunclassified

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Brändli-Baiocco

Balme

Bruder³

et al. 2018

J Toxicol Pathol

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the endocrine organs (pituitary gland, pineal gland, thyroid gland, parathyroid glands, adrenal glands and pancreatic islets) of laboratory rats and mice, with color photomicrographs illustrating examples of the lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for endocrine lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Pineal Glandunclassified

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Brändli-Baiocco

Balme

Bruder³

et al. 2018

J Toxicol Pathol

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“…Tumors of Pineal Gland Among laboratory animals, pinealoma has been described in rats but is extremely rare. Single cases were reported in aged rats of different strains including Crj:CD (SD) IGS (Furukawa et al 1999), WIST (Yamamoto et al 1991), F344 (Heath and Winokur 1998), and Osborne-Mendel (Dagle et al 1979).…”

Section: Primitive Neuroectodermal or Bipotential Tumorsmentioning

confidence: 99%

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Weber¹,

Garman²,

Germann³

et al. 2010

Toxicol Pathol

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Neoplasms of the nervous system, whether spontaneous or induced, are infrequent in laboratory rodents and very rare in other laboratory animal species. The morphology of neural tumors depends on the intrinsic functions and properties of the cell type, the interactions between the neoplasm and surrounding normal tissue, and regressive changes. The incidence of neural neoplasms varies with sex, location, and age of tumor onset. Although the onset of spontaneous tumor development cannot be established in routine oncogenicity studies, calculations using the time of diagnosis (day of death) have revealed significant differences in tumor biology among different rat strains. In the central nervous system, granular cell tumors (a meningioma variant), followed by glial tumors, are the most common neoplasms in rats, whereas glial cell tumors are observed most frequently in mice. Central nervous system tumors usually affect the brain rather than the spinal cord. Other than adrenal gland pheochromocytomas, the most common neoplasms of the peripheral nervous system are schwannomas. Neural tumors may develop in the central nervous system and peripheral nervous system from other cell lineages (including extraneural elements like adipose tissue and lymphocytes), but such lesions are very rare in laboratory animals.

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“…The expansive growth of tumor cells in the dorsal surface of the brain is also a biological feature of pinealomas in rats, even when the tumor is malignant 8 . In previous reports, the tumor masses were visible on the dorsal surface of the brain 9,[11][12][13][14] . However, unlike these previous reports of spontaneous pinealomas in rats, the present tumor occurred in the deep brain parenchyma and grew to a large mass invading the brain parenchyma.…”

mentioning

confidence: 83%

“…In humans, germinoma, formerly called pinealoma, has a unique feature of two cell patterns composed of large tumor cells and small infiltrated lymphocytes 6 . In contrast, pinealomas in rats derived from parenchymal cells of the pineal gland are reportedly composed of large and small tumor cells 9,10,12,13 .…”

mentioning

confidence: 94%

Malignant pinealoma observed in the deep cerebral parenchyma of a male Wistar rat

et al. 2022

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This report describes a case of spontaneous malignant pinealoma in a 90-week-old male Wistar rat. The tumor mass occurred in the deep cerebral parenchyma and no intact pineal gland was observed in the area between the posterior-dorsal median line of the cerebrum and the cerebellum. The tumor was characterized by a large nodular proliferation occupying the central area of the brain, extending from the dorsal surface to the base of the brain, corresponding to the thalamus. The tumor cells had round to irregular oblong nuclei approximately 5-17 μm in diameter and showed faintly or moderately eosinophilic cytoplasm and indistinct cell boundaries. Immunohistochemically, the tumor cells were positive for synaptophysin and partially positive for neuron-specific enolase (NSE). The tumor showed malignant features including cellular pleomorphism, high mitotic index, necrotic foci, and invasive and extensive growth and was, therefore, diagnosed as an extremely rare malignant pinealoma in the deep cerebral parenchyma.

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Spontaneous Pinealoma in a Male Crj:CD(SD)IGS Rat.

Cited by 4 publications

References 8 publications

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Malignant pinealoma observed in the deep cerebral parenchyma of a male Wistar rat

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