Abstract:Spontaneous pneumomediastinum (SP) was described early during the COVID-19 pandemic in large series of patient with severe pneumonia, but all partly involved patients with invasive mechanical ventilation (IMV) at the time of SP diagnosis. We aimed, in this retrospective multicenter observational study, to describe the prevalence and outcomes of SP during severe COVID-19 pneumonia before any IMV, in order to rule out mechanisms induced by IMV in the development of pneumomediastinum. A total of 551 patients were… Show more
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