Spontaneous Pneumothorax in Metastatic Thyroid Papillary Carcinoma

Lee, Mi Jung; Kim, Min Jung; Kwak, Jin Young; Hong, Soon Won; Park, Cheong Soo

doi:10.1200/jco.2007.11.0130

Cited by 20 publications

(10 citation statements)

References 9 publications

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“…The mechanism of secondary pneumothorax from lung metastases is unclear, although several theories have been proposed, including tumor necrosis, check valve, and tumor embolus [6]. Angiogenesis inhibitors are known to cause tumor necrosis and cavitations in lung lesions [7], which may possibly be the cause of pneumothorax during pazopanib treatment.…”

Section: Discussionmentioning

confidence: 99%

Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature

et al. 2017

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Pazopanib, a multitargeting tyrosine kinase inhibitor, has single-agent activity in patients with advanced soft-tissue sarcoma. Herein, we describe 2 cases of pneumothorax that occurred during pazopanib treatment in patients with soft-tissue sarcoma. These 2 patients had multiple lung metastases. According to previous reports and our past experience, the risk of pneumothorax may be higher in patients with multiple lung metastases. Although a causal relationship is uncertain, the risk of pneumothorax when prescribing pazopanib for these patients should be considered.

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Section: Discussionmentioning

confidence: 99%

Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature

et al. 2017

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“…On rare occasion, patients with primary or metastatic lung cancer present with spontaneous pneumothorax. [2][3][4][5][6][7][8][9] In the general population, 10 of 1,143 cases with spontaneous pneumothorax are attributed to a malignancy. 3 The most common malignant tumors are metastatic sarcomas, [3][4][5] including osteosarcoma and angiosarcoma, germ cell tumors 2 and primary lung cancers.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 We found two cases of spontaneous pneumothorax associated with metastatic thyroid carcinomas in the English medical literature. 8,9 Various mechanisms have been proposed as possible causes of spontaneous pneumothorax in patients with malignancy. Necrosis within a tumor itself, mechanical airway obstruction by tumor, chemotherapy-related tumor shrinkage and direct tumor invasion of the pleura may predispose a person to the development of pneumothorax.…”

Section: Discussionmentioning

confidence: 99%

“…1 Primary or metastatic malignant neoplasms are rare but very important underlying cause of spontaneous pneumothorax. [2][3][4][5][6][7][8][9] We report here on a 32-year-old male with microscopic pulmonary metastasis from a clinically undetected thyroid papillary carcinoma, who initially presented with recurrent spontaneous pneumothorax. This case was difficult to diagnose because the metastatic tumor exclusively revealed a follicular growth pattern and mild cytological atypia in an unusual anatomic site.…”

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confidence: 99%

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Spontaneous Pneumothorax as an Initial Manifestation of Metastatic Papillary Thyroid Carcinoma

Lee

Kim

2009

Korean J Pathol

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Spontaneous pneumothorax occurs in a variety of lung diseases. Primary or metastatic lung cancers are rare, but important causes of pneumothorax. We report here on a case of pulmonary metastasis of thyroid papillary carcinoma that initially presented as spontaneous pneumothorax. A 32-year-old male with no history of thyroid disease underwent wedge resection of the lung due to recurrent pneumothorax. Histologically, the pleura and subpleural lung parenchyma revealed several micronodular lesions and randomly scattered glandular structures with mild cytological atypia. The cells were characterized by their overlapped hypochromatic nuclei with longitudinal grooves and inconspicuous nucleoli. On the additional sections, we found a few intranuclear inclusions and colloid-like material in the follicular structures. The glandular cells were immunoreactive for thyroglobulin, TTF-1, CK 7 and HMW-CK and they were focally immunoreactive for EMA, but they were negative for S100, chromogranin and CEA. The Ki-67 labelling index was 4%. Neck ultrasonography revealed an ill-defined hypoechoic nodule in the left lobe of the thyroid. The diagnosis of conventional, classical papillary carcinoma was made by both the cytology and the total thyroidectomy specimen. Pathologists should conduct a through histologic examination for the patients with recurrent spontaneous pneumothorax to search for the underlying causes.

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“…[1,[7][8][9] Many sporadic case reports also describe SP due to lung metastases from angiosarcoma, metastatic thyroid (papillary, medullary) carcinoma, teratomas, Wilms' tumors, melanomas, carcinomas of the kidney and pancreas, metastatic ovarian granulosa cell tumor, testicular cancer, lymphomas, choriocarcinomas, and lymphangiomatosis. [6,[13][14][15][16] Sensitivity of detection of lung metastasis was 57% by chest x-ray and 88% by chest computed tomography. [8] Chest X-ray upright PA view is not 100% sensitive in diagnosing pneumothorax.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Pneumothorax as the Initial Presentation in an Osteosarcoma Patient: A Case Report

Kumar¹,

Sarangi²,

Mohanty³

et al. 2017

AIMDR

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Spontaneous pneumothorax (SP) is a very rare condition, mainly seen in patients with underlying lung diseases. Pneumothorax caused by lung metastasis occurs in 1% of whole spontaneous pneumothorax cases, especially in the setting of cytotoxic chemotherapy or radiotherapy. The most frequently involved tumor is osteogenic sarcoma. But, before initiation of chemotherapy, spontaneous pneumothorax as a complication of malignancy is rare. Herein, we report a case of spontaneous pneumothorax in a 19-year-old female with osteosarcoma of left ilium. The patient was not receiving chemotherapy or radiotherapy and was found to have pneumothorax at the initial presentation, which is rare. Chest CT revealed bilateral pulmonary metastases and right sided pneumothorax.

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Spontaneous Pneumothorax in Metastatic Thyroid Papillary Carcinoma

Cited by 20 publications

References 9 publications

Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature

Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature

Spontaneous Pneumothorax as an Initial Manifestation of Metastatic Papillary Thyroid Carcinoma

Spontaneous Pneumothorax as the Initial Presentation in an Osteosarcoma Patient: A Case Report

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