Spontaneous Pneumothorax in Wegener's Granulomatosis: Case Report and Literature Review

Belhassen-García, Moncef; Velasco‐Tirado, Virginia; Alvela-Suárez, Lucía; Carpio-Pérez, Adela; Lledías, Javier Pardo; Novoa, Nuria; Iglesias-Gómez, Alicia; Cordero-Sánchez, Miguel

doi:10.1016/j.semarthrit.2011.05.001

Cited by 9 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pneumothorax can be identified from radiologic findings, without any symptoms. In some cases, aggressive treatment of GPA is required 6,8 . Tension pneumothorax is a life‐threatening condition that has never been reported before in the context of GPA.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of the disease is made by abnormal kidney function tests, neutrophil predominance leukocytosis, elevated inflammatory markers, and rheumatoid factors 5 . The most common radiologic findings from chest radiography and computed tomography scanning are single or multiple diffuse nodules and cavitation, patchy and diffuse opacities 6 . Treatment of GPA includes pleural drainage (particularly in patients with respiratory problems), surgery corticosteroid, and immunosuppressants, depending on the nature of the disease and associated prognosis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tension pneumothorax in a patient with granulomatosis

Ahmadinejad

Afrasiabi

2020

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tension pneumothorax in a patient with granulomatosis

Ahmadinejad

Afrasiabi

2020

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…9 According to different studies, the incidence of pneumothorax in Wegener's granulomatosis (WG) is between 3 to 5%. 12,13 In certain reported cases of WG, the occurrence of pneumothorax was attributed to the rupture of cavitary lesions and immunosuppressive treatment. 9 In a literature review by Tanaka et al, 13 11 patients with recurrent pneumothorax with SLE were evaluated.…”

Section: Discussionmentioning

confidence: 99%

Takayasu arteritis presenting with spontaneous pneumothorax

Hızal¹,

Polat²,

Özen³

et al. 2020

Turk J Pediatr

View full text Add to dashboard Cite

Background. Takayasu arteritis (TA) is an idiopathic chronic inflammatory arteritis that affects the large blood vessels. Pulmonary involvement was considered an uncommon manifestation of the disease and spontaneous pneumothorax has not been previously described in association with TA. Case. We report a 13-year-old female who had TA complicated by spontaneous pneumothorax during treatment. She was admitted to the hospital reporting difficulty standing from a squatting position and inability to walk without support. She had been diagnosed with dilate cardiomyopathy four years ago and cardiac functions had deteriorated over time. Catheter angiography revealed diffuse narrowing of the abdominal aorta. In magnetic resonance angiography, total-subtotal occlusion of the infrarenal abdominal aorta in a 2 cm area and subtotal occlusion of the left renal artery were detected without pulmonary artery involvement. Methotrexate, azathioprine, and prednisolone were administered. Tension pneumothorax developed on the left side while she was on prednisolone treatment. Conclusion. To our knowledge, this is the first case of spontaneous pneumothorax associated with TA to be reported in the literature.

show abstract

“…For patients not responding to pleural drainage, thoracotomy should be performed [ 21 ]. Also, for patients complicated with pleural infection, adequate drainage is essential [ 20 ]. Otherwise, extubation should be considered to reduce the risk of infection.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and treatment of pneumothorax secondary to granulomatosis with polyangiitis: a clinical analysis of 25 cases

Shi

Zhang

2018

J Cardiothorac Surg

View full text Add to dashboard Cite

ObjectivesTo investigate the risk factors and treatment strategies for pneumothorax secondary to granulomatosis with polyangiitis (GPA).MethodRetrospective analysis of cases with pneumothorax secondary to GPA from our own practice and published on literature.ResultsA total of 25 patients, 18 males and 7 females, mean age 44 ± 15.7 years, were analyzed. Diagnosis included pneumothorax (11 cases), hydropneumothorax (n = 5), empyema (n = 8) and hemopneumothorax (n = 1). 88% (22/25) patients showed single/multiple pulmonary/ subpleural nodules with/without cavitation on chest imaging. Erythrocyte sedimentation rate and C-reactive protein were both elevated. Corticosteroids and immunosuppressive agents were used in 16 cases. Five cases received steroid pulse therapy, of which 4 patients survived. Pleural drainage was effective in some patients. Seven patients underwent surgical operations. In the 10 fatal cases, infection and respiratory failure were the most common cause. Lung biopsy/ autopsy showed lung/pleural necrotizing granulomatous vasculitis, breaking into the chest cavity, pleural fibrosis, bronchial pleural fistula, etc. The mean age in the death group was greater than the survival group (53 ± 12.9 years vs 40.1 ± 14.7 years, p = 0.05), the ineffective pleural drainage was also higher in the death group (5/5 vs 0/7, p = 0.01).ConclusionsPneumothorax was seen in the active GPA, due to a variety of reasons, and gave rise to high fatality rate. Aggressive treatment of GPA can improve the prognosis. Older and lack of response for pleural drainage indicates poor prognosis.

show abstract

Spontaneous Pneumothorax in Wegener's Granulomatosis: Case Report and Literature Review

Cited by 9 publications

References 21 publications

Tension pneumothorax in a patient with granulomatosis

Tension pneumothorax in a patient with granulomatosis

Takayasu arteritis presenting with spontaneous pneumothorax

Risk factors and treatment of pneumothorax secondary to granulomatosis with polyangiitis: a clinical analysis of 25 cases

Contact Info

Product

Resources

About