Spontaneous Pneumothorax

Sahn, Steven A.; Heffner, John E.

doi:10.1056/nejm200003233421207

Cited by 653 publications

(559 citation statements)

References 74 publications

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“…The average smoking history was 30 pack-years (range, 15-48), and of those who died, the mean age at the time of death from lung disease was 62 years (range, 46-68, n = 7, Table 3). Notably, 3 of 9 subjects had spontaneous pneumothorax (33%), a rare, life-threatening complication of COPD that normally affects 5% of cases (23). Relative to historic estimates, the likelihood of recurrent spontaneous pneumothorax in this genetically uniform subset occurring by chance alone is low (P = 0.016, Fisher's exact test).…”

Section: Resultsmentioning

confidence: 99%

Telomerase mutations in smokers with severe emphysema

Stanley¹,

Chen²,

Podlevsky³

et al. 2014

J. Clin. Invest.

161

140

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Section: Resultsmentioning

confidence: 99%

Telomerase mutations in smokers with severe emphysema

Stanley¹,

Chen²,

Podlevsky³

et al. 2014

J. Clin. Invest.

161

140

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“…Approximately one century afterward, in 1932, the first description of pneumothorax occurring in healthy subjects (primary spontaneous pneumothorax, PSP) was published by Kjaergaard [2]. Pneumothorax is currently classified as: i) spontaneous (i.e., not caused by trauma or any obvious precipitating factor); ii) traumatic (secondary to both penetrating and blunt chest trauma); and iii) iatrogenic (i.e., secondary to medical procedures or surgical interventions) [3,4]. Spontaneous pneumothorax (SP) is further subdivided in: i) primary spontaneous pneumothorax (PSP), occurring in subjects without clinically apparent lung disease; and ii) secondary spontaneous pneumothorax (SSP), when representing a complication of a preexisting lung disease.…”

Section: Introductionmentioning

confidence: 99%

Incidence of primary spontaneous pneumothorax is not associated with microclimatic variations. Results of a seven-year survey in a temperate climate area

Comelli

Bologna

Ticinesi

et al. 2017

Monaldi Arch Chest Dis

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Some diseases, such as renal colic and atrial fibrillation, display an association with microclimatic variations. In particular, despite a correlation has been reported between incidence of primary spontaneous pneumothorax (PSP) and meteorological variations, the evidence remains poor and conflictual. The aim of this study was to assess the influence of day-by-day meteorological variations on the number of visits for PSP in the Emergency Department (ED). All PSP cases were retrieved from the hospital database from January 2008 to December 2014. For all the observational days, meteorological data about the Parma Province were obtained from the Environment and Climate Regional Agency. The correlation between ED visits for PSP and variation of air temperature (T°), atmospheric pressure (hPa) and humidity (%) was then tested. The chronological data of all the visits for PSP were correlated with climate data by univariate linear regressions analysis. A total number of 608.215 ED visits were recorded during the observational period, with an average of 238 patients per day. Overall, 257 PSP cases were observed (mean age 37±21 years), 79% males and 21% females. No significant correlation between average daily visits for PSP and daily change of average temperature, humidity, or atmospheric pressure was observed throughout the observational period (p>0.05 for all). The results of the study show that the incidence of PSP is not significantly associated with changes of microclimatic variables.

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“…Previous research has focused on describing pneumothorax within the traditional classifications: primary spontaneous, secondary spontaneous, or traumatic (from either iatrogenic or noniatrogenic causes) (1)(2)(3).…”

mentioning

confidence: 99%

Pneumothorax Risk Factors in Smokers with and without Chronic Obstructive Pulmonary Disease

Hobbs¹,

Bowler²,

Jacobson³

et al. 2014

Annals ATS

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Rationale: The demographic, physiological, and computed tomography (CT) features associated with pneumothorax in smokers with and without chronic obstructive pulmonary disease (COPD) are not clearly defined.Objectives: We evaluated the hypothesis that pneumothorax in smokers is associated with male sex, tall and thin stature, airflow obstruction, and increased total and subpleural emphysema. Methods:The study included smokers with and without COPD from the COPDGene Study, with quantitative chest CT analysis. Pleural-based emphysema was assessed on the basis of local histogram measures of emphysema. Pneumothorax history was defined by subject self-report.Measurements and Main Results: Pneumothorax was reported in 286 (3.2%) of 9,062 participants. In all participants, risk of prior pneumothorax was significantly higher in men (odds ratio [OR], 1.55; 95% confidence interval [CI], 1.08-2.22) and non-Hispanic white subjects (OR, 1.90; 95% CI, 1.34-2.69). Risk of prior pneumothorax was associated with increased percent CT emphysema in all participants and participants with COPD (OR, 1.04 for each 1% increase in emphysema; 95% CI, 1.03-1.06). Increased pleural-based emphysema was independently associated with risk of past pneumothorax in all participants (OR, 1.05 for each 1% increase; 95% CI, 1.01-1.10). In smokers with normal spirometry, risk of past pneumothorax was associated with non-Hispanic white race and lifetime smoking intensity (OR, 1.20 for every 10 pack-years; 95% CI, 1.09-1.33).Conclusions: Among smokers, pneumothorax is associated with male sex, non-Hispanic white race, and increased percentage of total and subpleural CT emphysema. Pneumothorax was not independently associated with height or lung function, even in participants with COPD.Clinical trial registered with www.clinicaltrials.gov (NCT00608764).

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Spontaneous Pneumothorax

Cited by 653 publications

References 74 publications

Telomerase mutations in smokers with severe emphysema

Telomerase mutations in smokers with severe emphysema

Incidence of primary spontaneous pneumothorax is not associated with microclimatic variations. Results of a seven-year survey in a temperate climate area

Pneumothorax Risk Factors in Smokers with and without Chronic Obstructive Pulmonary Disease

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