Spontaneous pregnancy in a patient with a combination of ovarian and thyroid failure

Abstract

SUMMARYPremature ovarian failure has an overall prevalence of 0.3% to 0.9% in general population. If fertility is a concern, treatment usually consists of estrogen therapy as hormone replacement and oocyte donation. Spontaneous pregnancy in affected women is uncommon. We report a case of a 34-year old woman, who had premature ovarian failure and primary hypothyroidism, and conceived spontaneously eleven years after the development of premature ovarian failure and correction of hypothyroidism. Arq Bras Endocrinol Metab. 2011;55(4):291-3 SUMÁRIO A falência ovariana prematura tem uma prevalência global variando de 0,3% a 0,9% na população em geral. Nos casos em que existe preocupação com a fertilidade, o tratamento geralmente consiste de terapia de reposição hormonal com estrógeno e doação de oócitos. A gravidez espontânea em mulheres afetadas não é comum. Relatamos um caso de uma mulher de 34 anos de idade que apresentou falência ovariana prematura e hipotireoidismo primário e concebeu espontaneamente onze anos após o desenvolvimento da falência ovariana prematura e da correção do hipotireoidismo. Arq Bras Endocrinol Metab. 2011;55(4):291-3

Pregnancy following diagnosis of premature ovarian insufficiency: a systematic review

“…In 5-10% of cases of POI, however, pregnancy can occur naturally, with hormone replacement therapy (HRT), IVF, or, more recently, in-vitro maturation (IVM) or with stem cell therapy . Numerous case reports also support this statement (TABLE 1) (Check et al, 2000;Nawroth et al, 2000;Zargar et al, 2000;Takahashi et al, 2001;Fernandes, 2002;Hershlag and Schuster 2002;Chao et al, 2003;Eldeen and Fawzi, 2003;Muller et al, 2003;Patel et al, 2003;Aslam et al, 2004;Menezo et al, 2004;Vital-Reyes et al, 2004;Corrigan et al, 2005;Check and Katsoff, 2006;Vandborg and Lauszus, 2006;Liza et al, 2008;Dragojevic-Dikic et al, 2009;Genazzani, 2009;Neves-e-Castro, 2009;Selvaraj et al, 2010;Chen and Chen, 2011;Ebrahimi et al, 2011, Ferrau et al, 2011Laway et al, 2011;Tartagni et al, 2011;Ghazeeri and Awwad, 2012;Grynberg et al, 2013;Maruyama et al, 2013;Soave et al, 2013;Tsuji et al, 2013;Rogenhofer et al, 2014;Warenik-Szymankiewicz and Slopien 2014;Roth and Alvero, 2014;Li et al, 2016).…”