Spontaneous Regeneration of Whole Mandible After Total Mandibulectomy in a Sickle Cell Patient

Jaw cysts – Filling or no filling after enucleation? A review

“…Similar results were observed in canine mandibles where defects greater than 15 mm failed to heal when the periosteum was removed in contrast to spontaneous bone healing in defects up to 50 mm when the periosteum was preserved (Huh et al, 2005). One report showed spontaneous osteogenesis in mandibular segmental defects even when the whole mandible was resected with preservation of the periosteum (Ogunlewe et al, 2006). The periosteum seems to have a higher osteogenic potential than the adjacent bone edges (Lemperle et al, 1998;Huh et al, 2005).…”

“…This procedure is stimulated by various cytokines, growth factors (e.g. PDGFs, IGFs, FGFs, TGF-b, BMPs) and stem cells (Schenk et al, 1994;Buser et al, 1998;Schliephake, 2002;Ogunlewe et al, 2006;Rodeo et al, 2010). Over the following 4 months desmoplastic bone is replaced by parallel-fibred bone resembling the original Haversian bone structure (Lemperle et al, 1998).…”

Self-Regeneration of the Mandible Following Hemimandibulectomy for Ameloblastoma: A Case Report and Review of Literature

“…Ogunlewe et al reported spontaneous regeneration of the whole mandible after total that mandibulectomy with bilateral disarticulation occurred in a 13-year old sickle-cell patient without the need for bone graft. Interestingly, the spontaneous bone regeneration in their case was noticed 10 weeks post-operatively; and by IIG inadequate information given, ING information not given a Individual patient's age, gender, and diagnosis were not specified 1 year of the operation, there was regeneration of the entire mandible with well-shaped condyles [15]. Moreover; dental implants have been placed successfully in spontaneously regenerated bone after mandibular resection [16].…”

“…However, this seems to be contradictory to the hypothesis of immobilization. Because the exact factors that enable the periosteum to regenerate bone are not fully understood, it has been suggested that the periosteum should always be preserved when carrying out mandibular resection for benign lesions that have not perforated the cortical plates and invaded the surrounding soft tissues [15].…”

Spontaneous bone regeneration following mandibular resection for odontogenic myxoma

“…[1][2] In the mandible, SBR has replaced extensive defects up to the entire mandible and bilateral condyles. [3][4][5] The exact factors controlling SBR are yet to be identified, but the age of the patient, presence of infection, soft tissue protection of the bone defect, immobilization and genetic factors have been suspected. [4][5][6][7][8][9][10][11] Sub-Saharan Africa reports of SBR are very rare; all previous accounts have come from Nigeria following jaw resection for ameloblastoma.…”