Spontaneous Regression of a Conjunctival Malignant Melanoma

Miller, Christina; Cook, I S; Jayaramachandran, Rama; Tyers, A G

doi:10.3109/01676830.2013.851708

Cited by 8 publications

(8 citation statements)

References 8 publications

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“…However, there are conflict results regarding its effects on the immune system of cancer pathogenesis in the literature. 26 , 27 In our study, patients with atypical MBC present significant superior rates of RFS, which is not previously reported in the literature. We thought it was due to less tumor growth and angiogenesis with fewer lymphocytes, and mononuclear infiltration in atypical MBC.…”

Section: Discussioncontrasting

confidence: 51%

Hormone receptor status and survival of medullary breast cancer patients

Aksoy

Odabaş

Kaya

et al. 2017

SMJ

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Objectives:To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC).Methods:Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis.Results:Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p<0.05). The PR negativity and smaller tumor were found to be favourable factors by univariate analysis (p<0.05). However, none of these factors were determined as significant independent prognostic factors for OS (p>0.05).Conclusion:Turkish MBC patients exhibited good prognosis, which was comparable with survival outcomes achieved in the literature. The PR negativity was related to a better RFS and OS rates.

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Section: Discussioncontrasting

confidence: 51%

Hormone receptor status and survival of medullary breast cancer patients

Aksoy

Odabaş

Kaya

et al. 2017

SMJ

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“…The spontaneous regression of malignant tumors is occasionally observed. 3,4 Inhibition of tumor growth and angiogenesis by biopsy-induced immunologic process is proposed as the main mechanism of spontaneous regression of malignant tumors. 3,4 However, none of the reported cases with FSCH was found to regress sponta- neously or after biopsy, and it is unclear whether this mechanism can be applied to this benign tumor or not.…”

Section: Discussionmentioning

confidence: 99%

Regression of Folliculosebaceous Cystic Hamartoma in the Palpebral Conjunctiva After Incisional Biopsy

Takahashi

Vaidya

Kakizaki

2022

Journal of Craniofacial Surgery

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A 72-year-old man presented with a mass in the lower palpebral conjunctiva on the left side that recurred after biopsy at another clinic. On the first examination, a hard, yellow-white mass was located in the lower palpebral conjunctiva on the left side with some vessels running onto the tumor surface. A small piece of the tumor was removed for pathologic examination, and the results of the examination corresponded to folliculosebaceous cystic hamartoma. The patient noticed reduction in size of the residual tumor at 3 weeks postbiopsy. Slit-lamp examination revealed considerable regression of the tumor. At 6 months of follow-up, the tumor did not recur.

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“…5 Tumors with a tendency for spontaneous regression include testicular germ cell tumors, cutanenous melanomas, basal cell carcinoma, renal cell carcinoma and rarely breast carcinoma, carcinoma colon and neuroblastoma. 5 Ocular and periocular malignancies, rarely regress spontaneously but this phenomenon has been reported with periocular basal cell carcinoma, 11 sebaceous gland carcinoma, 12 eyelid Merkel cell carcinoma, 13 conjunctival lymphoma, 14 conjunctival melanoma 15 ocular surface squamous neoplasia, 6–10 keratoacanthoma, 8 choroidal melanoma, 16 retinoblastoma 17 and intraocular lymphoma. 18 The present study focussed on the clinical features and outcomes in spontaneously regressed presumed OSSN lesions of which, the literature is limited to isolated case reports.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous regression of presumed ocular surface squamous neoplasia: A report of 8 cases

Vempuluru

Ghose

Vithalani

et al. 2021

European Journal of Ophthalmology

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Purpose To report the phenomenon of spontaneous regression in presumed ocular surface squamous neoplasia (OSSN) Methods Retrospective chart review of clinically diagnosed cases of OSSN during 2016 to 2019 Results Of the 449 OSSN lesions, spontaneous regression was seen in 8 lesions (2%). The mean age at diagnosis of OSSN was 37 years (median, 36 years; range, 21 to 59 years). All were males with unilateral, treatment-naïve tumors. Mean duration of symptoms was 3 months (median, 2 months; range, 1 to 12 months). All tumors arose within the interpalpebral region, located in the nasal quadrant in 88% (n = 7) and in temporal quadrant in 12% (n = 1). The mean tumor diameter was 4 mm (median, 4 mm; range, 3 to 5 mm). Lesions showed nodular (n = 4; 50%) or placoid (n = 4; 50%) morphology. The other features included keratin production and intrinsic vascularity (n = 8; 100%), feeder vessels (n = 4; 50%), and intratumoral pigmentation (n = 4; 50%). The diagnosis of OSSN was confirmed by classic anterior segment optical coherence tomography (AS-OCT) features. Tumors regressed after a mean period of 5 months (median, 4 months; range, <1 to 17 months) from presumed onset and a mean period of 2 months (median, 1 month; range, <1 to 6 months) from presentation to the clinic. No recurrences were noted at a mean follow up of 37 months (median, 35 months; range, 17 to 52 months) after spontaneous regression of tumors. Conclusion OSSN can spontaneously regress in 2% of cases. Immune-mediated reversal of dysplastic changes may explain this phenomenon. Précis In this study, spontaneous regression of presumed ocular surface squamous neoplasia was noted in 2% patients. Tumor regression resulted in restoration of normal epithelial architecture and no recurrences were observed during the follow-up period.

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Spontaneous Regression of a Conjunctival Malignant Melanoma

Abstract: Spontaneous regression is not always synonymous with complete cure from the underlying disease but may represent a temporary regression due to host protective mechanisms. In our patient regression and cure were complete.

Cited by 8 publications

References 8 publications

Hormone receptor status and survival of medullary breast cancer patients

Hormone receptor status and survival of medullary breast cancer patients

Regression of Folliculosebaceous Cystic Hamartoma in the Palpebral Conjunctiva After Incisional Biopsy

Spontaneous regression of presumed ocular surface squamous neoplasia: A report of 8 cases

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