Spontaneous Regression of a Putative Childhood Hepatoma

McSweeney, William J.; Bove, Kevin E.; McAdams, A. James

doi:10.1001/archpedi.1973.04160040092019

Cited by 6 publications

(1 citation statement)

References 6 publications

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“…'-I4 However, of the latter publications, the reexamination of one case resulted in its' reclassification as a variant of a benign hemangioendothelioma. '', 22 Another report lacked a primary tissue diagnosis, relying instead on a compatible radiologic appearance and the histologic examination of a single metastasi~. '~ A third case was published after a follow-up time of only 48 months,I3 although longer survival times have been reported in HCC patients who eventually die of their di~ease.…”

Section: Resultsmentioning

confidence: 99%

Spontaneous regression of hepatocellular carcinoma

Gaffey

Joyce

Carlson

et al. 1990

Cancer

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A surgically unresectable, biopsy-proven hepatocellular carcinoma (HCC) developed in a 63-year-old man with cirrhosis. He survived 24 months without treatment. During that time the tumor burden decreased as demonstrated both radiologically and by the normalization of alpha-fetoprotein levels. The patient died of complications secondary to repeated esophageal variceal hemorrhage. Necropsy demonstrated prominent, ulcerated esophageal varices and liver cirrhosis without evidence of neoplasia either grossly or on a subsequent thorough microscopic examination. This case represents the first confirmation of HCC spontaneous regression in which a primary histologic diagnosis was confirmed by immunohistochemical and flow cytometric DNA analysis, and where tumor regression was proven by a thorough necropsy examination.

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Section: Resultsmentioning

confidence: 99%