Spontaneous regression of angiolymphoid hyperplasia with eosinophilia of lacrimal gland in an HIV-positive patient

Kumari, Pooja; Kasturi, Nirupama; Nagarajan, Gayatri; Senthamizh, Tharini; Ramesh, B K; Bheemanathi, Hanuman Srinivas

doi:10.4103/ijo.ijo_1634_18

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…TBUT values decrease [ 105 ]. HIV Transconjunctival exposure [ 106 ], ocular mucosal infection [ 107 ] Inflammatory infiltration in LG [ 49 ]. Discomfort, foreign body sensation of the eye, TBUT reduction [ 56 ].…”

Section: Conclusion and Prospectmentioning

confidence: 99%

“…The aetiology of DED in HIV patients is usually due to HIV-mediated lymphocytic infiltration in the LGs [ 48 ]. A clinical case study reported that the left LG mass of an HIV-infected patient shows dense inflammatory infiltration, composed of mature lymphocytes, plasma cells, and endothelial cells [ 49 ]. Chronic inflammation promotes cytokine secretion, resulting in LG dysfunction, which contributes to a reduction in tear production [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

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Dry eye disease caused by viral infection: Past, present and future

Wu,

Sun,

Shi

et al. 2023

Virulence

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Following viral infection, the innate immune system senses viral products, such as viral nucleic acids, to activate innate defence pathways, leading to inflammation and apoptosis, control of cell proliferation, and consequently, threat to the whole body. The ocular surface is exposed to the external environment and extremely vulnerable to viral infection. Several studies have revealed that viral infection can induce inflammation of the ocular surface and reduce tear secretion of the lacrimal gland (LG), consequently triggering ocular morphological and functional changes and resulting in dry eye disease (DED). Understanding the mechanisms of DED caused by viral infection and its potential therapeutic strategies are crucial for clinical interventional advances in DED. This review summarizes the roles of viral infection in the pathogenesis of DED, applicable diagnostic and therapeutic strategies, and potential regions of future studies.

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Section: Conclusion and Prospectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dry eye disease caused by viral infection: Past, present and future

Wu,

Sun,

Shi

et al. 2023

Virulence

View full text Add to dashboard Cite

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Ophthalmic Manifestations of Angiolymphoid Hyperplasia with Eosinophilia: A Systematic Review and Pooled Analysis of 86 Cases

Ahmed,

Thrishulamurthy,

Venkatesh

et al. 2024

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: This systematic review aims to consolidate evidence on ophthalmological manifestations of angiolymphoid hyperplasia with eosinophilia, focusing on its presentation, diagnosis, and management. Methods: Preferred reporting items for systematic reviews and meta-analyses-adherent systematic review was conducted across 3 databases from inception until September 2024. Case reports and series detailing angiolymphoid hyperplasia with eosinophilia in ocular structures were included. Data on demographics, clinical presentation, diagnostic methods, and treatment outcomes were extracted and analyzed. Results: A total of 86 patients from 52 case reports/series were included. The median age was 41 years (IQR: 22–54), with a slight male predominance (51.16%, n = 44/86). The majority of patients (94.18%, n = 81/86) presented with unilateral eye involvement. The orbit was the most frequently involved location (45.35%, n = 39/86), followed by the upper eyelid (27.91%, n = 24/86). Clinical symptoms included proptosis (36.04%, n = 31/86), ptosis (26.74%, n = 23/86), and diplopia (11.67%, n = 10/86). Surgical excision was performed in 54.65% (n = 47/86) of cases, with biopsy done for diagnostic purposes in all patients. Recurrence occurred in 13.95% (n = 12/86), with risk factors including incomplete excision and prior angiolymphoid hyperplasia with eosinophilia in the same or opposite eye. Steroid therapy was used in 18.6% (n = 16/86) but showed limited success. Newer treatment strategies with propranolol showed efficacy in recurrent cases, with no recurrence reported in patients receiving this therapy. Conclusion: Angiolymphoid hyperplasia with eosinophilia in ocular structures presents diagnostic and therapeutic challenges. Surgical excision remains the mainstay of treatment, though recurrence is common. Therapeutic strategies with propranolol may offer alternative management options in recurrent cases.

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