Spontaneous Regression of Bilateral Conjunctival Extranodal Marginal Zone B-cell Lymphoma of Mucosa-Associated Lymphoid Tissue

Matsuo, Toshihiko; Ichimura, Kouichi; Yoshino, Tadashi

doi:10.3960/jslrt.47.79

Cited by 22 publications

(17 citation statements)

References 6 publications

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“…Orbital LPDs, including MALT lymphoma, sometimes regress spontaneously [20,21]. Pathologic examination has not revealed any differences between MTX-LPD and other types of LPD [12].…”

Section: Discussionmentioning

confidence: 95%

Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

et al. 2016

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The patient was a 74-year-old Japanese woman with rheumatoid arthritis (RA) who developed generalized lymphadenopathy with elevated levels of lactase dehydrogenase (LD), and soluble IL-2 receptor (sIL-2R). She was found to be positive for anti-human T-cell leukemia virus type 1 (HTLV-1) antibodies. Her symptoms and laboratory abnormalities spontaneously regressed after the cessation of methotrexate (MTX), suggesting that she had an MTX-associated lymphoproliferative disorder; however, her lymphadenopathy appeared again approximately 14 months later with LD and sIL-2R elevation. A histopathological analysis and Southern blotting of a lymph node biopsy specimen for HTLV-1 provirus supported the diagnosis of adult T-cell leukemia/lymphoma (ATL) (lymphoma type). These data confirmed that an HTLV-1 positive RA patient may develop ATL.

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“…Orbital LPDs, including MALT lymphoma, sometimes regress spontaneously [20,21]. Pathologic examination has not revealed any differences between MTX-LPD and other types of LPD [12].…”

Section: Discussionmentioning

confidence: 95%

Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

et al. 2016

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“…The conjunctival lesions (salmon-pink lesions) in the present patient appeared clinically similar to B-cell and Tcell lymphomas [1][2][3][4]6,7 as well as benign lymphoid hyperplasia. [8][9][10] Leukemic infiltration of the conjunctiva is rare but does occur to present the same clinical picture as lymphoma.…”

Section: Fig 4 Whole-body 2-[mentioning

confidence: 96%

“…The most frequent pathological type of primary lymphoma, occurring in the conjunctiva, is extranodal marginal zone Bcell lymphoma of the mucosa-associated lymphoid tissue (MALT), or MALT lymphoma. [1][2][3][4] Indeed, the conjunctiva has been shown to have mucosa (conjunctiva)-associated lymphoid tissue, which can be acquired in the normal condition. 5 Other less common types of primary lymphoma in the conjunctiva, which have been reported so far, include T-cell lymphoma 6 and Burkitt lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Conjunctival Lesions in Blastic Plasmacytoid Dendritic Cell Neoplasm

Matsuo

Ichimura

Tanaka

et al. 2011

J Clin Exp Hematopathol

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The purpose of this study is to report on a patient who developed conjunctival lesions of blastic plasmacytoid dendritic cell neoplasm (BPDCN) after radiation to skin lesions of the same pathological type. A 79-year-old man developed salmon-pink lesions in the lower fornix of the conjunctiva of both eyes and biopsy revealed BPDCN. One and a half years previously, he noticed an erythematous plaque with a 30-mm diameter, which later became multiple, on the left chest, and the biopsy revealed BPDCN. The bone marrow was negative for CD56-positive cells, but fluorescence-activated cell sorting analysis of peripheral blood cells revealed a group of cells positive for CD4 and CD56, or CD4 and CD123. The monocyte fraction, in an increased percentage of white blood cell counts, did contain atypical cells positive for the three markers. Whole-body 2-[18 F]fluoro-2-deoxy-D-glucose positron emission tomography combined with computed tomography demonstrated no abnormal uptake lesions. He received 30 Gy of radiation to the chest lesions, and later, the same dose of radiation to novel skin lesions on the back, waist, and chest, and also to pharyngeal lesions. In conclusion, the conjunctiva could be involved with BPDCN and pathological differential diagnosis by biopsy is mandatory to establish the correct diagnosis. 〔J Clin Exp Hematopathol 51(1) : 49-55, 2011〕

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“…58 Thus, EMZL appears to develop as a result of prolonged antigen stimulation that leads to loss of regulation of B-lymphocyte proliferation and differentiation. 37 Several characteristics of conjunctival EMZL give rise to the suspicion that this mechanism also triggers EMZL development in the conjunctiva: 1) conjunctival EMZL is often bilateral and may show spontaneous remission, which could be the result of bilateral conjunctival infection and clearance of an antigen, respectively 84,85 ; 2) the t(11;18)(q21;q21) translocation, which is related to oxidative damage induced by genotoxic factors such as H pylori or C psittaci infection, is present in 19% of conjunctival EMZLs 148 ; 3) in some cases, patients with conjunctival EMZL have a history of preceding infectious conjunctivitis. 42 A number of studies have investigated the association between the infectious agents and conjunctival lymphoma.…”

Section: Chronic Antigenic Stimulationmentioning

confidence: 99%