Spontaneous regression of cervical lymph node metastasis in a patient with mesopharyngeal squamous cell carcinoma of the tongue: possible association between apoptosis and tumor regression

Kurita, Masanori; Hirano, Kazuya; Ebihara, Satoshi; Takushima, Akihiko; Harii, Kiyonori; Fukushima, Takashi; Fujioka, Yasunori

doi:10.1007/s10147-007-0711-9

Cited by 15 publications

(11 citation statements)

References 22 publications

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“…The literature thus supports the idea that this phenomenon remains extremely rare in head and neck cancer . After these review articles were published, there has been one report of spontaneous regression of squamous cell carcinoma of the tongue with lymph node metastases . However, our patient receiving AgNP would, to the best of our knowledge, be the first reported case of spontaneous regression of head and neck cancer involving distant metastases.…”

Section: Discussionsupporting

confidence: 78%

Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer

et al. 2018

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Background: Silver nanoparticles (AgNP) show efficacy in cancer cell lines. We present the first in-human outcome of AgNP in a cancer patient. Methods: Homemade AgNP solution is manufactured using online instructions by a 78-year old male. He started consuming AgNP while on hospice after he developed nasal cavity squamous cell cancer metastatic to liver and lung. Results: Electron microscopy of AgNP solution revealed bimodal nanoparticle size distribution: 3 and 12 nm. Inductively coupled plasma mass spectrometry showed basal silver ion concentrations of 32 ng/g, rising to 46 ng/g 1 hour after ingesting 60 mL of AgNP solution. Urine showed no AgNP. No toxicities were observed and he had complete radiographic resolution of his cancer. He remains without evidence of cancer 18 months later.

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Section: Discussionsupporting

confidence: 78%

Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer

et al. 2018

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“…Moreover, metastatic cells that eventually reach the lymph nodes (which are highly active sites of the immune system), in addition to being partially blocked, markedly stimulate the immune system. Cases of spontaneous regression of lymph node metastases of carcinoma have been reported (28).…”

Section: Review Of the Literature And Discussionmentioning

confidence: 99%

Spontaneous regression of malignant tumors: Importance of the immune system and other factors (Review)

Ricci

Cerchiari

2010

Oncology Letters

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Abstract. It has been established that malignant tumors as well as metastases, of almost all histological types, can regress spontaneously although certain histological types regress more frequently than others. Various causes thereof include apoptosis, the immune system and particular conditions of the tumor microenvironment. The action of the genome in the regression of tumors is not clear, but some data, apart from those of apoptosis, support its involvement. The hypothesis that the immune system exhibits variations in efficacy, even to a marked extent, in determining partial or total regression of tumors appears to be plausible. Such variable efficacy may be supported by blockage of growth and the proliferation of cancer cells at the level of the tumor microenvironment, the intervention of various factors such as inhibitors of metalloproteinases and angiogenesis, and the absence or scarcity of particular proteins. The consequence of such a blockage would be a relative increase in the number of natural killer cells and other elements involved in the immune system in relation to the number of circulating cancer cells in the blood. A relative increase in the number of elements of the immune system is more effective than an absolute increase, since an absolute increase is able to stimulate, as frequently occurs for feedback in biological equilibria, inhibitor receptors that reduce the efficacy of the same elements (mainly natural killer and CD8 + T cells). Such an increase in the efficacy of the immune system can lead, at least in certain cases, to the so-called spontaneous regression of malignant tumors. Clinical practice has demonstrated that metastases are less frequent in patients with renal carcinoma undergoing hemodialysis compared with patients with renal carcinoma not on hemodialysis. This finding can be interpreted, in correlation with the blockage of cancer cells in tissues, as a consequence of a partial blockage of metastatic cancer cells at the level of the dialytic membrane, with a subsequent increase in the relative efficacy of the immune system.

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“…Inflammation, sometimes triggered by an acute infection, has also been implicated in regression of metastatic disease 40 . Complete regression of widespread metastases in the absence of any relevant treatment has been reported in a wide variety of neoplasms, ranging from squamous‐cell carcinoma of the skin and mucous membranes to hepatocellular carcinoma and renal cell carcinoma and from seminoma to Merkel cell carcinoma 41–45 . In melanoma, the incidence of spontaneous regression of metastases has been estimated to be one per 400 patients 35 …”

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confidence: 99%

The ‘epidemic’ of melanoma between under‐ and overdiagnosis

Weyers

2011

J Cutan Pathol

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In the past decades, the incidence of melanoma has been reported to rise in epidemic proportions. The chief reason for that pseudo-epidemic is improved criteria for diagnosis that allow melanomas to be recognized far more accurately and at earlier stages. The rising number of melanomas diagnosed has resulted in increased diagnostic scrutiny, more pigmented lesions being biopsied and more melanomas recognized, thus enhancing the 'epidemic' in self-perpetuating fashion. Regression of melanomas may, in part, explain why lesions undetected before did not result in a far higher mortality. Another potential reason for the disparity between increasing incidence of melanoma and relatively steady mortality may be overdiagnosis of melanoma. The latter may be curtailed by establishment of well-defined diagnostic categories, efforts to establish reliable criteria for recognition of those categories, better clinicopathologic correlation, postponement of biopsy of pigmented lesions in the case of irritation and excisional rather than incisional biopsies.

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Spontaneous regression of cervical lymph node metastasis in a patient with mesopharyngeal squamous cell carcinoma of the tongue: possible association between apoptosis and tumor regression

Cited by 15 publications

References 22 publications

Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer

Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer

Spontaneous regression of malignant tumors: Importance of the immune system and other factors (Review)

The ‘epidemic’ of melanoma between under‐ and overdiagnosis

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