Spontaneous Regression of Hepatocellular Carcinoma: Three Case Reports and a Categorized Review of the Literature

Oquiñena, Susana; Iñarrairaegui, Mercedes; Vila, Juan J.; Alegre, Félix; Zozaya, José Manuel; Sangro, Bruno

doi:10.1007/s10620-008-0447-z

Cited by 47 publications

(30 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HCC is clinically chemotherapy-resistant to numerous cytotoxic agents. Immunotherapy has also so far failed to improve survival [4][5][6] . Recently, promising results have been obtained for sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor and the platelet-derived growth factor [7] .…”

Section: Introductionmentioning

confidence: 99%

Image-Guided Interstitial High-Dose-Rate Brachytherapy in Hepatocellular Carcinoma

Mohnike

Wieners

Pech

et al. 2009

Dig Dis

View full text Add to dashboard Cite

New interventional options especially for patients with HCC and BCLC scores B and C give rise to disputes about the optimal therapeutic management. CT-guided brachytherapy complements established interventional techniques like RFA and TACE since it may also be used successfully in tumors much greater than 5 cm in diameter. In addition, unlike thermal ablation, the brachytherapy technique may be applied in tumors located nearby risk structures such as liver hilum or gallbladder and it is independent of cooling effects such as through large blood vessels or strong tumor perfusion. Depending on tumor size, geometry and visibility, MRI or CT guidance may be used. 15 Gy minimal target dose can be applied safely in a single or – in case of very large tumors – a sequential approach targeting different tumor portions. Local recurrence rates will be very low, and the rate of complications is moderate despite the fact that most patients present with underlying cirrhosis and related comorbidities. Preliminary data suggest a positive impact on overall survival. Randomized controlled trials are on their way to assess combination schemes with systemic treatments such as sorafenib.

show abstract

Section: Introductionmentioning

confidence: 99%

Image-Guided Interstitial High-Dose-Rate Brachytherapy in Hepatocellular Carcinoma

Mohnike

Wieners

Pech

et al. 2009

Dig Dis

View full text Add to dashboard Cite

show abstract

“…Oquiñena & co-workers [2] described partial or complete spontaneous regression of HCC in 3 patients and reviewed literature of 65 such patients reported earlier. The causative factors and mechanisms leading to spontaneous regression of HCC are unclear, however two causes have been considered [3].…”

Section: Discussionmentioning

confidence: 99%

Unusual Behaviour of Hepatocellular Carcinoma in a Patient with Liver Cirrhosis

Gupta¹

2016

GHOA

View full text Add to dashboard Cite

show abstract

“…A newer perspective is more revealing: Very few reports of SR in cancers of the lung, colon, or pancreas suggest a prevalence of < 1: 1,000,000 in these frequent types of cancer. However, SR in indolent malignant lymphoma or in metastatic renal cell carcinoma occur in at least 1 out of 100 patients [4][5][6][7], and the frequency of SR in hepatocellular cancer was calculated to be 0.4% [8]. SR in non-MYCN amplified neuroblastoma IVS is observed in about 80% of young patients [9].…”

Section: Introductionmentioning

confidence: 99%

Metachronous Spontaneous Remission of Melanoma Lung Metastasis and Mediastinal Lymph Node Metastases

Kappauf¹,

G²

2018

Oncol Res Treat

View full text Add to dashboard Cite

Background: Spontaneous remissions are rare but valid events in malignancies and in the past have led to the development of mainstay oncologic therapies. Case Report: We present a rare case of spontaneous regression of a solitary pulmonary melanoma metastasis with complete remission persisting for 28 months. Concurrent mediastinal nodal metastases progressed at the time of remission of the lung metastasis, but also demonstrated regression in follow-up fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) imaging. Metastatic nodes showed only minimal residual metabolic activity after 38 months of follow-up from the appearance of metastatic disease. Conclusion: This case report presents a rare spontaneous complete regression of a solitary pulmonary melanoma metastasis. Biological pathways involved in spontaneous regression in cancer are discussed.

show abstract

Spontaneous Regression of Hepatocellular Carcinoma: Three Case Reports and a Categorized Review of the Literature

Cited by 47 publications

References 46 publications

Image-Guided Interstitial High-Dose-Rate Brachytherapy in Hepatocellular Carcinoma

Image-Guided Interstitial High-Dose-Rate Brachytherapy in Hepatocellular Carcinoma

Unusual Behaviour of Hepatocellular Carcinoma in a Patient with Liver Cirrhosis

Metachronous Spontaneous Remission of Melanoma Lung Metastasis and Mediastinal Lymph Node Metastases

Contact Info

Product

Resources

About