Spontaneous Regression of Laryngeal Squamous Cell Carcinoma After Biopsy

Watkins, Mariel O.; Tate, Alan D.; Lewis, James S.; Garrett, C. Gaelyn

doi:10.1177/0145561320939834

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…Regulatory T-lymphocyte density does not seem to be predictive of disease evolution in LCH. However, in reports on laryngeal cancer 6 and B-cell lymphoma, 7 the regression observed after the biopsy was attributed to a probable activation of the immune response 6 or a disruption in the microenvironment, eliciting immune reaction due to the trauma of the procedure. 7 …”

Section: Discussionmentioning

confidence: 98%

Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker)

Lima¹,

Amorim²,

Marinho³

et al. 2022

Anais Brasileiros de Dermatologia

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Section: Discussionmentioning

confidence: 98%

Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker)

Lima¹,

Amorim²,

Marinho³

et al. 2022

Anais Brasileiros de Dermatologia

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“…It is reported that surgical stimulation attracts immune cells and activate local immune responses ( 7 ). These attracted immune cells, especially anti-cancerous immune cells, induce the process of cancer cell killing, also known as “Immunogenic cell death (ICD)” ( 8 ). Given these mechanisms, we hypothesized that the stimulation of CNBs caused the SR in this case.…”

Section: Discussionmentioning

confidence: 99%

Breast carcinoma with spontaneous regression after needle biopsy: a case report and literature review

Sasamoto¹,

Yamada²,

Oshi³

et al. 2023

Gland Surg

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Background Spontaneous regression (SR) of cancer is a rare condition in which the cancer partially or completely disappears without treatment. We report a case of breast cancer with tumor regression and spontaneously induced T-cell-mediated immunological responses in a surgical specimen obtained after core needle biopsy (CNB). Case Description A 52-year-old woman presented with a mass in the right breast. Mammography showed a high-density mass with fine serrated margins in the right lower outer quadrant. Breast ultrasonography showed an irregular hypoechoic mass with a maximum diameter of 22 mm. CNB was performed and revealed an invasive ductal carcinoma with negative estrogen receptors, positive progesterone receptors, and negative HER2 (1+). The Ki67 index was 70% to 80%. Luminal B cT2N1M0 stage IIB right breast cancer was diagnosed. Although preoperative chemotherapy was considered, surgery was selected because of her history of schizophrenia. She underwent right mastectomy and axillary lymph node dissection. A postoperative pathological analysis revealed a 20 mm × 10 mm × 10 mm mass. However, most areas of the mass regressed and appeared as necrotic tissue with no obvious invasive areas. Only intraductal extension was observed in one glandular duct. Axillary lymph node metastases were not observed. These results suggest that the tumor may have spontaneously regressed, possibly because of the CNB procedure. Follow-up without treatment was performed, and no recurrence occurred during 2 years after surgery. Conclusions Invasive ductal carcinoma may spontaneously regress after preoperative CNB.

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Spontaneous regression of head and neck squamous cell carcinoma: a systematic review and meta-analysis of case reports

Lau,

Ferozepurwalla

2024

J. Laryngol. Otol.

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Objective A systematic review of case reports in spontaneous regression of head and neck squamous cell carcinoma (SCC) was carried out to investigate the pattern and characteristics of this phenomenon. Methods A systematic search of case studies of spontaneously regressed head and neck SCC was carried out in Ovid Embase, Ovid Medline and Pubmed. Methodological quality was assessed by ascertainment of diagnosis and overall details of reports. Outcomes included patient demographics, head and neck SCC characteristics and clinical course of disease. Results A total of 8 cases were included and 50 per cent (n = 4) of the reported cases were SCC of the vocal folds. All cases received a surgical biopsy and three cases had possible febrile episodes preceding regression. The mean length of time to regression was 4.3 months. Discussion Spontaneous regression in head and neck SCC is likely to be under-reported. A better understanding of how the host immune system can instigate an antitumour response will shed light on the development of novel treatments.

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Spontaneous Regression of Laryngeal Squamous Cell Carcinoma After Biopsy

Cited by 4 publications

References 9 publications

Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker)

Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker)

Breast carcinoma with spontaneous regression after needle biopsy: a case report and literature review

Spontaneous regression of head and neck squamous cell carcinoma: a systematic review and meta-analysis of case reports

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